FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136768370> ?p ?o ?g. }

• W3136768370 endingPage "517" @default.
• W3136768370 startingPage "507" @default.
• W3136768370 abstract "We attempt to investigate the biological function of the discoidin, complement C1r/C1s,Uegf, and Bmp1 and Limulus factor C, Coch, and Lgl domain-containing 2 (DCBLD2) in glioblastoma, as well as its effect on the epithelial-mesenchymal transition (EMT) process.The public expression data of glioblastoma samples and normal brain samples from The Cancer Genome Atlas database, Genotype-Tissue Expression database and Chinese Glioma Genome Atlas database were used to analyze the expression of DCBLD2 and its relationship with the survival of patients with glioblastoma. Quantitative real-time PCR and western blot were used to evaluate mRNA and protein levels of DCBLD2. Cell viabilities were tested using Cell Counting Kit-8 and clone formation assays. Cell invasive and migratory abilities were measured by transwell assays.DCBLD2 expression was upregulated in glioblastoma and has a significantly positive correlation with the WHO classification. In addition, high expression of DCBLD2 was closely correlated with poor prognosis in primary and recurrent patients with glioblastoma. What is more, we found that knockdown of DCBLD2 notably reduced the cell proliferative, invasive and migratory capacities by elevating the expression of E-cadherin and inhibiting the expression of vimentin, snail, slug and twist. However, overexpression of DCBLD2 presented the opposite results.The current study reveals that high expression of DCBLD2 is closely related to poor prognosis in glioblastoma and can significantly enhance the tumor cell viability and metastasis by activating the EMT process, suggesting that DCBLD2 may be a possible biomarker for glioblastoma treatment." @default.
• W3136768370 created "2021-03-29" @default.
• W3136768370 creator A5003616240 @default.
• W3136768370 creator A5010052157 @default.
• W3136768370 creator A5021582167 @default.
• W3136768370 creator A5024962900 @default.
• W3136768370 creator A5029360035 @default.
• W3136768370 creator A5048952647 @default.
• W3136768370 creator A5067146984 @default.
• W3136768370 date "2021-04-07" @default.
• W3136768370 modified "2023-10-14" @default.
• W3136768370 title "Transmembrane protein DCBLD2 is correlated with poor prognosis and affects phenotype by regulating epithelial-mesenchymal transition in human glioblastoma cells" @default.
• W3136768370 cites W1592915341 @default.
• W3136768370 cites W1977918192 @default.
• W3136768370 cites W1978310782 @default.
• W3136768370 cites W1991025954 @default.
• W3136768370 cites W2005133489 @default.
• W3136768370 cites W2005805484 @default.
• W3136768370 cites W2022554267 @default.
• W3136768370 cites W2050613603 @default.
• W3136768370 cites W2058799772 @default.
• W3136768370 cites W2069541017 @default.
• W3136768370 cites W2071948601 @default.
• W3136768370 cites W2082173307 @default.
• W3136768370 cites W2088029995 @default.
• W3136768370 cites W2099180770 @default.
• W3136768370 cites W2114104545 @default.
• W3136768370 cites W2138538638 @default.
• W3136768370 cites W2147587303 @default.
• W3136768370 cites W2154700978 @default.
• W3136768370 cites W2160382843 @default.
• W3136768370 cites W2296457333 @default.
• W3136768370 cites W2567652734 @default.
• W3136768370 cites W2607129810 @default.
• W3136768370 cites W2724976913 @default.
• W3136768370 cites W2743924567 @default.
• W3136768370 cites W2744617133 @default.
• W3136768370 cites W2750357431 @default.
• W3136768370 cites W2772208910 @default.
• W3136768370 cites W2803329568 @default.
• W3136768370 cites W2884626935 @default.
• W3136768370 cites W2886266170 @default.
• W3136768370 cites W2940672137 @default.
• W3136768370 cites W3011100303 @default.
• W3136768370 cites W4242403727 @default.
• W3136768370 cites W4250899941 @default.
• W3136768370 doi "https://doi.org/10.1097/wnr.0000000000001611" @default.
• W3136768370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33788813" @default.
• W3136768370 hasPublicationYear "2021" @default.
• W3136768370 type Work @default.
• W3136768370 sameAs 3136768370 @default.
• W3136768370 citedByCount "3" @default.
• W3136768370 countsByYear W31367683702022 @default.
• W3136768370 countsByYear W31367683702023 @default.
• W3136768370 crossrefType "journal-article" @default.
• W3136768370 hasAuthorship W3136768370A5003616240 @default.
• W3136768370 hasAuthorship W3136768370A5010052157 @default.
• W3136768370 hasAuthorship W3136768370A5021582167 @default.
• W3136768370 hasAuthorship W3136768370A5024962900 @default.
• W3136768370 hasAuthorship W3136768370A5029360035 @default.
• W3136768370 hasAuthorship W3136768370A5048952647 @default.
• W3136768370 hasAuthorship W3136768370A5067146984 @default.
• W3136768370 hasConcept C104317684 @default.
• W3136768370 hasConcept C121608353 @default.
• W3136768370 hasConcept C127561419 @default.
• W3136768370 hasConcept C127716648 @default.
• W3136768370 hasConcept C137738243 @default.
• W3136768370 hasConcept C142724271 @default.
• W3136768370 hasConcept C147447768 @default.
• W3136768370 hasConcept C1491633281 @default.
• W3136768370 hasConcept C173396325 @default.
• W3136768370 hasConcept C198826908 @default.
• W3136768370 hasConcept C203014093 @default.
• W3136768370 hasConcept C204232928 @default.
• W3136768370 hasConcept C2776415932 @default.
• W3136768370 hasConcept C2778227246 @default.
• W3136768370 hasConcept C2779013556 @default.
• W3136768370 hasConcept C502942594 @default.
• W3136768370 hasConcept C54355233 @default.
• W3136768370 hasConcept C71924100 @default.
• W3136768370 hasConcept C76419328 @default.
• W3136768370 hasConcept C81885089 @default.
• W3136768370 hasConcept C86803240 @default.
• W3136768370 hasConcept C95444343 @default.
• W3136768370 hasConceptScore W3136768370C104317684 @default.
• W3136768370 hasConceptScore W3136768370C121608353 @default.
• W3136768370 hasConceptScore W3136768370C127561419 @default.
• W3136768370 hasConceptScore W3136768370C127716648 @default.
• W3136768370 hasConceptScore W3136768370C137738243 @default.
• W3136768370 hasConceptScore W3136768370C142724271 @default.
• W3136768370 hasConceptScore W3136768370C147447768 @default.
• W3136768370 hasConceptScore W3136768370C1491633281 @default.
• W3136768370 hasConceptScore W3136768370C173396325 @default.
• W3136768370 hasConceptScore W3136768370C198826908 @default.
• W3136768370 hasConceptScore W3136768370C203014093 @default.
• W3136768370 hasConceptScore W3136768370C204232928 @default.
• W3136768370 hasConceptScore W3136768370C2776415932 @default.
• W3136768370 hasConceptScore W3136768370C2778227246 @default.

• next