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- W3136771572 abstract "To investigate the material basis and mechanism of Liupao tea on preventing COVID-19 by network pharmacology and molecular docking The active ingredients and targets of Liupao tea were searched through the literature and the TCMSP databases and the network between the two was built by Cytoscape 3 7 1 Then using GenCards platform to predict the disease targets,mapping the common targets between Liupao tea and disease The common targets were imported into the STRING database for exploring the protein-protein interaction Core targets were enriched by gene ontology (GO) enrichment analysis and KEGG (kyoto encyclopedia of genes and genomes) pathway enrichment analysis using DAVID database etc Finally,the screened active components were docked with the receptor protein SARS-CoV-2 3CL hydrolase (Mpro) Six active ingredients of Liupao tea were screened,such as (-)-epigallocatechin gallate (EGCG),(+)-catechin,(-)-eatechin gallate, α-spinasterol,pelargonidin chloride and squalene,and 156 targets were identified Among them, there were 112 common targets and 38 core targets with COVID-19 GO enrichment analysis (P<0 01) involved lipopolysaccharide,cell response to hypoxia, etc And the KEGG pathway enrichment analysis (P<0 01)was conducted to obtain the HIF-1,IL-17,T cell receptor and other signaling pathways associated with COVID-19 The results of molecular docking showed that the active ingredients of Liupao tea were well bound to the receptor protein Mpro The active ingredients of Liupao tea may control HIF-1,IL-17,T cell receptors signaling pathways by binding Mprohydrolase and acting on inflammation and immune related targets such as MAPK1,TNF to prevent COVID-19 The EGCG of Mproactivity was determined,and the IC50was 3 4 μmol/L,which confirmed that EGCG was a certain inhibition effect on Mpro © 2020 China Pharmaceutical University All rights reserved" @default.
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- W3136771572 date "2020-01-01" @default.
- W3136771572 modified "2023-09-27" @default.
- W3136771572 title "Potential active compounds of Liupao tea for prevention and treatment of COVID-19 based on network pharmacology and molecular docking" @default.
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