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- W3136788331 abstract "Vulvar squamous cell carcinoma arises from precursor lesions: vulvar intraepithelial neoplasias (VIN). Most of them are caused by the human papillomavirus (HPV), and the precursor lesion for this group is VIN usual type/high grade squamous intraepithelial lesion (uVIN/HSIL) of variable clinical presentation and having a light invasive potential. Some VIN are HPV-independent and arise in older women against the background of chronic dermatoses, mostly lichen sclerosus. Their histological diagnosis is more subtle. They have a higher invasive potential. A third precursor, leading to well-differentiated, or even verrucous, carcinomas, is still ill-defined to this day. We detail these lesions' clinics, histology, and biomarkers (immunohistochemical and molecular)." @default.
- W3136788331 created "2021-03-29" @default.
- W3136788331 creator A5052544627 @default.
- W3136788331 date "2022-01-01" @default.
- W3136788331 modified "2023-09-27" @default.
- W3136788331 title "Les néoplasies intraépithéliales vulvaires" @default.
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- W3136788331 doi "https://doi.org/10.1016/j.annpat.2021.02.014" @default.
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