FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136792904> ?p ?o ?g. }

• W3136792904 abstract "Abstract Microbial communities in the airways of persons with CF (pwCF) are variable, may include genera that are not typically associated with CF, and their composition can be difficult to correlate with long-term disease outcomes. Leveraging two large datasets characterizing sputum communities of 167 pwCF and associated metadata, we identify five bacterial community types. These communities explain 24% of the variability in lung function in this cohort, far more than single factors like Simpson diversity, which explains only 4%. Subjects with Pseudomonas -dominated communities tended to be older and have reduced percent predicted FEV 1 (ppFEV 1 ) than subjects with Streptococcus -dominated communities, consistent with previous findings. To assess the predictive power of these five communities in a longitudinal setting, we used random forests to classify 346 additional samples from 24 subjects observed 8 years on average in a range of clinical states. Subjects with mild disease were more likely to be observed at baseline, that is, not in the context of a pulmonary exacerbation, and community structure in these subjects was more self-similar over time, as measured by Bray-Curtis distance. Interestingly, we found that subjects with mild disease were more likely to remain in a mixed Pseudomonas community, providing some support for the climax-attack model of the CF airway. In contrast, patients with worse outcomes were more likely to show shifts among community types. Our results suggest that bacterial community instability may be a risk factor for lung function decline and indicates the need to better understand factors that drive shifts in community composition." @default.
• W3136792904 created "2021-03-29" @default.
• W3136792904 creator A5030383333 @default.
• W3136792904 creator A5036077732 @default.
• W3136792904 creator A5041236219 @default.
• W3136792904 creator A5069506982 @default.
• W3136792904 creator A5071725218 @default.
• W3136792904 date "2021-03-24" @default.
• W3136792904 modified "2023-09-27" @default.
• W3136792904 title "Mild CF Lung Disease is Associated with Bacterial Community Stability" @default.
• W3136792904 cites W1848355102 @default.
• W3136792904 cites W1904652721 @default.
• W3136792904 cites W1966729619 @default.
• W3136792904 cites W1971558827 @default.
• W3136792904 cites W1991980138 @default.
• W3136792904 cites W2018403515 @default.
• W3136792904 cites W2028837330 @default.
• W3136792904 cites W2071949631 @default.
• W3136792904 cites W2080554049 @default.
• W3136792904 cites W2087128002 @default.
• W3136792904 cites W2088620429 @default.
• W3136792904 cites W2088707861 @default.
• W3136792904 cites W2094167812 @default.
• W3136792904 cites W2095566399 @default.
• W3136792904 cites W2096288151 @default.
• W3136792904 cites W2096641887 @default.
• W3136792904 cites W2098914778 @default.
• W3136792904 cites W2099751660 @default.
• W3136792904 cites W2106855493 @default.
• W3136792904 cites W2121640835 @default.
• W3136792904 cites W2122587604 @default.
• W3136792904 cites W2131585020 @default.
• W3136792904 cites W2142231009 @default.
• W3136792904 cites W2147618390 @default.
• W3136792904 cites W2149879965 @default.
• W3136792904 cites W2163792002 @default.
• W3136792904 cites W2236839872 @default.
• W3136792904 cites W2559009252 @default.
• W3136792904 cites W2770873502 @default.
• W3136792904 cites W2782826582 @default.
• W3136792904 cites W2792090253 @default.
• W3136792904 cites W2888562344 @default.
• W3136792904 cites W2892264332 @default.
• W3136792904 cites W2905907296 @default.
• W3136792904 cites W2911964244 @default.
• W3136792904 cites W2922470685 @default.
• W3136792904 cites W2925144085 @default.
• W3136792904 cites W2940998296 @default.
• W3136792904 cites W2963276645 @default.
• W3136792904 cites W2979464486 @default.
• W3136792904 cites W2989994975 @default.
• W3136792904 cites W3007945801 @default.
• W3136792904 cites W3008061956 @default.
• W3136792904 cites W3034510336 @default.
• W3136792904 cites W3040090596 @default.
• W3136792904 cites W3084455175 @default.
• W3136792904 cites W3096906050 @default.
• W3136792904 cites W3119039855 @default.
• W3136792904 cites W4236653231 @default.
• W3136792904 doi "https://doi.org/10.1101/2021.03.23.436717" @default.
• W3136792904 hasPublicationYear "2021" @default.
• W3136792904 type Work @default.
• W3136792904 sameAs 3136792904 @default.
• W3136792904 citedByCount "0" @default.
• W3136792904 crossrefType "posted-content" @default.
• W3136792904 hasAuthorship W3136792904A5030383333 @default.
• W3136792904 hasAuthorship W3136792904A5036077732 @default.
• W3136792904 hasAuthorship W3136792904A5041236219 @default.
• W3136792904 hasAuthorship W3136792904A5069506982 @default.
• W3136792904 hasAuthorship W3136792904A5071725218 @default.
• W3136792904 hasBestOaLocation W31367929041 @default.
• W3136792904 hasConcept C126322002 @default.
• W3136792904 hasConcept C142724271 @default.
• W3136792904 hasConcept C144024400 @default.
• W3136792904 hasConcept C149923435 @default.
• W3136792904 hasConcept C151730666 @default.
• W3136792904 hasConcept C151956035 @default.
• W3136792904 hasConcept C2776301714 @default.
• W3136792904 hasConcept C2777014857 @default.
• W3136792904 hasConcept C2777895361 @default.
• W3136792904 hasConcept C2779134260 @default.
• W3136792904 hasConcept C2779343474 @default.
• W3136792904 hasConcept C2781069245 @default.
• W3136792904 hasConcept C71924100 @default.
• W3136792904 hasConcept C72563966 @default.
• W3136792904 hasConcept C74909509 @default.
• W3136792904 hasConcept C77350462 @default.
• W3136792904 hasConcept C86803240 @default.
• W3136792904 hasConceptScore W3136792904C126322002 @default.
• W3136792904 hasConceptScore W3136792904C142724271 @default.
• W3136792904 hasConceptScore W3136792904C144024400 @default.
• W3136792904 hasConceptScore W3136792904C149923435 @default.
• W3136792904 hasConceptScore W3136792904C151730666 @default.
• W3136792904 hasConceptScore W3136792904C151956035 @default.
• W3136792904 hasConceptScore W3136792904C2776301714 @default.
• W3136792904 hasConceptScore W3136792904C2777014857 @default.
• W3136792904 hasConceptScore W3136792904C2777895361 @default.
• W3136792904 hasConceptScore W3136792904C2779134260 @default.
• W3136792904 hasConceptScore W3136792904C2779343474 @default.
• W3136792904 hasConceptScore W3136792904C2781069245 @default.

• next