Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136803533> ?p ?o ?g. }
- W3136803533 abstract "Neuropathological diseases of the central nervous system (CNS) are frequently associated with impaired differentiation of the oligodendroglial cell lineage and subsequent alterations in white matter structure and dynamics. Down syndrome (DS), or trisomy 21, is the most common genetic cause for cognitive impairments and intellectual disability (ID) and is associated with a reduction in the number of neurons and oligodendrocytes, as well as with hypomyelination and astrogliosis. Recent studies mainly focused on neuronal development in DS and underestimated the role of glial cells as pathogenic players. This also relates to C21ORF91, a protein considered a key modulator of aberrant CNS development in DS. We investigated the role of C21orf91 ortholog in terms of oligodendrogenesis and myelination using database information as well as through cultured primary oligodendroglial precursor cells (OPCs). Upon modulation of C21orf91 gene expression, we found this factor to be important for accurate oligodendroglial differentiation, influencing their capacity to mature and to myelinate axons. Interestingly, C21orf91 overexpression initiates a cell population coexpressing astroglial- and oligodendroglial markers indicating that elevated C21orf91 expression levels induce a gliogenic shift towards the astrocytic lineage reflecting non-equilibrated glial cell populations in DS brains." @default.
- W3136803533 created "2021-03-29" @default.
- W3136803533 creator A5002124119 @default.
- W3136803533 creator A5009956359 @default.
- W3136803533 creator A5039108736 @default.
- W3136803533 creator A5041748189 @default.
- W3136803533 creator A5049700987 @default.
- W3136803533 creator A5053953664 @default.
- W3136803533 creator A5062004838 @default.
- W3136803533 creator A5067675145 @default.
- W3136803533 creator A5068838014 @default.
- W3136803533 creator A5077603725 @default.
- W3136803533 date "2021-03-16" @default.
- W3136803533 modified "2023-09-30" @default.
- W3136803533 title "C21orf91 Regulates Oligodendroglial Precursor Cell Fate—A Switch in the Glial Lineage?" @default.
- W3136803533 cites W1515784600 @default.
- W3136803533 cites W1927878378 @default.
- W3136803533 cites W1938046568 @default.
- W3136803533 cites W1964683842 @default.
- W3136803533 cites W1974565082 @default.
- W3136803533 cites W1976152949 @default.
- W3136803533 cites W1988023818 @default.
- W3136803533 cites W1988585329 @default.
- W3136803533 cites W1989059764 @default.
- W3136803533 cites W1992657248 @default.
- W3136803533 cites W1997233742 @default.
- W3136803533 cites W2001748283 @default.
- W3136803533 cites W2001810970 @default.
- W3136803533 cites W2004588076 @default.
- W3136803533 cites W2004750343 @default.
- W3136803533 cites W2009909585 @default.
- W3136803533 cites W2014632182 @default.
- W3136803533 cites W2014827000 @default.
- W3136803533 cites W2017537291 @default.
- W3136803533 cites W2017868723 @default.
- W3136803533 cites W2018973123 @default.
- W3136803533 cites W2030241802 @default.
- W3136803533 cites W2032596241 @default.
- W3136803533 cites W2038651295 @default.
- W3136803533 cites W2040114944 @default.
- W3136803533 cites W2059650080 @default.
- W3136803533 cites W2059994807 @default.
- W3136803533 cites W2062991065 @default.
- W3136803533 cites W2068795982 @default.
- W3136803533 cites W2075852460 @default.
- W3136803533 cites W2098425296 @default.
- W3136803533 cites W2106596862 @default.
- W3136803533 cites W2110163390 @default.
- W3136803533 cites W2119704718 @default.
- W3136803533 cites W2119831515 @default.
- W3136803533 cites W2124531570 @default.
- W3136803533 cites W2124940469 @default.
- W3136803533 cites W2125650861 @default.
- W3136803533 cites W2132167906 @default.
- W3136803533 cites W2136582464 @default.
- W3136803533 cites W2138699364 @default.
- W3136803533 cites W2149414924 @default.
- W3136803533 cites W2149924247 @default.
- W3136803533 cites W2156545134 @default.
- W3136803533 cites W2165990617 @default.
- W3136803533 cites W2167279371 @default.
- W3136803533 cites W2287180374 @default.
- W3136803533 cites W2295979384 @default.
- W3136803533 cites W2461219450 @default.
- W3136803533 cites W2501957447 @default.
- W3136803533 cites W2561475925 @default.
- W3136803533 cites W2586756969 @default.
- W3136803533 cites W2589128164 @default.
- W3136803533 cites W2600710575 @default.
- W3136803533 cites W2608680016 @default.
- W3136803533 cites W2740903678 @default.
- W3136803533 cites W2757511757 @default.
- W3136803533 cites W2762704480 @default.
- W3136803533 cites W2799578891 @default.
- W3136803533 cites W2802110824 @default.
- W3136803533 cites W2836368391 @default.
- W3136803533 cites W2900795146 @default.
- W3136803533 cites W2918236375 @default.
- W3136803533 cites W2945416878 @default.
- W3136803533 cites W2964806222 @default.
- W3136803533 cites W2981931461 @default.
- W3136803533 cites W2994323406 @default.
- W3136803533 cites W336932370 @default.
- W3136803533 cites W4294540597 @default.
- W3136803533 doi "https://doi.org/10.3389/fncel.2021.653075" @default.
- W3136803533 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8008080" @default.
- W3136803533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33796011" @default.
- W3136803533 hasPublicationYear "2021" @default.
- W3136803533 type Work @default.
- W3136803533 sameAs 3136803533 @default.
- W3136803533 citedByCount "8" @default.
- W3136803533 countsByYear W31368035332021 @default.
- W3136803533 countsByYear W31368035332022 @default.
- W3136803533 countsByYear W31368035332023 @default.
- W3136803533 crossrefType "journal-article" @default.
- W3136803533 hasAuthorship W3136803533A5002124119 @default.
- W3136803533 hasAuthorship W3136803533A5009956359 @default.
- W3136803533 hasAuthorship W3136803533A5039108736 @default.
- W3136803533 hasAuthorship W3136803533A5041748189 @default.
- W3136803533 hasAuthorship W3136803533A5049700987 @default.