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• W3136807342 abstract "Most of the studies on the herb Chuanxiong Rhizoma (CR) have focused on the l-arginine-nitric oxide (NO) pathway, but the nitrate-nitrite-NO (NO3--NO2--NO) pathway was rarely investigated. Therefore, the aim of this study was to evaluate the effects and mechanisms of action of CR in coronary artery disease (CAD).The NO3-, NO2- and NO levels were examined in the NO3--NO2--NO pathway. High-performance ion chromatography was used to quantify NO3- and NO2- levels. Then, NO was quantified using a multifunctional enzyme marker with a fluorescent probe. The tension of aortic rings was measured using a multi myograph system.High content of NO3- and low content of NO2- was found in CR, and which could potently convert NO3- to NO2- in the presence of endogenous reductase enzyme. Incubating human coronary artery endothelial cells (HCAECs) with CR-containing serum showed that CR significantly decreased the NO3- content and increased the levels of NO2- and NO in the cells under hypoxic conditions. In addition, CR significantly relaxed isolated aortic rings when the l-arginine -NO pathway was blocked. The optimal concentration of CR for relaxation was 200 mg/mL.CR supplements large amounts of NO in cells and vessels to achieve relaxation via the NO3--NO2--NO pathway, thereby making up for the deficiency caused by the lack of NO after the l-arginine-NO pathway is suppressed. This study also supports the potential use of a traditional Chinese herb for future drug development." @default.
• W3136807342 created "2021-03-29" @default.
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• W3136807342 date "2021-07-01" @default.
• W3136807342 modified "2023-10-02" @default.
• W3136807342 title "Molecular mechanism of Chuanxiong Rhizoma in treating coronary artery diseases" @default.
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• W3136807342 doi "https://doi.org/10.1016/j.chmed.2021.03.001" @default.
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