Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136840282> ?p ?o ?g. }
- W3136840282 endingPage "2009924" @default.
- W3136840282 startingPage "2009924" @default.
- W3136840282 abstract "Supramolecular approaches have opened up vast possibilities to construct versatile materials, especially those with stimuli-responsiveness and integrated functionalities of multi-modal diagnosis and synergistic therapeutics. In this study, a hybrid theranostic nanosystem named TTPY-Py⊂[email protected] is constructed via facile host–guest interactions, where TTPY-Py is a photosensitizer with aggregation-induced emission and [email protected] represents the carboxylatopillar[5]arene (CP5)-modified Au nanorods. TTPY-Py⊂[email protected] integrates the respective advantages of TTPY-Py and [email protected] such as the high performance of reactive oxygen species generation and photothermal conversion, and meanwhile shows fluorescence responses to both temperature and pH stimuli. The successful modification of CP5 macrocycles on AuNRs surfaces can eliminate the cytotoxicity of AuNRs and enable them to serve as the nanocarrier of TTPY-Py for further theranostic applications. Significantly, in vitro and in vivo evaluations demonstrate that this supramolecular nanotheranostic system possesses multiple modalities including intensive fluorescence imaging (FLI), photoacoustic imaging (PAI), efficient photodynamic therapy (PDT), and photothermal therapy (PTT), indicating its great potential for FLI-PAI imaging-guided synergistic PDT-PTT therapy. Moreover, TTPY-Py can be released upon activation by the acidic environment of lysosomes and then specifically light up mitochondria. This study demonstrates a new strategy for the design of versatile nanotheranostics for accurate tumor imaging and cancer therapies." @default.
- W3136840282 created "2021-03-29" @default.
- W3136840282 creator A5000103532 @default.
- W3136840282 creator A5023493981 @default.
- W3136840282 creator A5028883319 @default.
- W3136840282 creator A5044901407 @default.
- W3136840282 creator A5046454314 @default.
- W3136840282 creator A5056248574 @default.
- W3136840282 creator A5065830827 @default.
- W3136840282 creator A5073216396 @default.
- W3136840282 creator A5079560786 @default.
- W3136840282 creator A5079808603 @default.
- W3136840282 creator A5089379373 @default.
- W3136840282 date "2021-03-18" @default.
- W3136840282 modified "2023-09-30" @default.
- W3136840282 title "Pillar[5]arene‐Modified Gold Nanorods as Nanocarriers for Multi‐Modal Imaging‐Guided Synergistic Photodynamic‐Photothermal Therapy" @default.
- W3136840282 cites W1818705748 @default.
- W3136840282 cites W2025118667 @default.
- W3136840282 cites W2025295644 @default.
- W3136840282 cites W2030068259 @default.
- W3136840282 cites W2088252867 @default.
- W3136840282 cites W2129931358 @default.
- W3136840282 cites W2177603935 @default.
- W3136840282 cites W2198939625 @default.
- W3136840282 cites W2255569422 @default.
- W3136840282 cites W2271756729 @default.
- W3136840282 cites W2321828396 @default.
- W3136840282 cites W2783250776 @default.
- W3136840282 cites W2784033799 @default.
- W3136840282 cites W2786395686 @default.
- W3136840282 cites W2790409421 @default.
- W3136840282 cites W2805188481 @default.
- W3136840282 cites W2809125283 @default.
- W3136840282 cites W2888586602 @default.
- W3136840282 cites W2898548717 @default.
- W3136840282 cites W2901885458 @default.
- W3136840282 cites W2908699371 @default.
- W3136840282 cites W2914850315 @default.
- W3136840282 cites W2919380077 @default.
- W3136840282 cites W2936484022 @default.
- W3136840282 cites W2936513263 @default.
- W3136840282 cites W2946835450 @default.
- W3136840282 cites W2964946408 @default.
- W3136840282 cites W2965104365 @default.
- W3136840282 cites W2969652379 @default.
- W3136840282 cites W2970565407 @default.
- W3136840282 cites W2975278306 @default.
- W3136840282 cites W2979261039 @default.
- W3136840282 cites W2979650873 @default.
- W3136840282 cites W2980750738 @default.
- W3136840282 cites W2981081933 @default.
- W3136840282 cites W2982232089 @default.
- W3136840282 cites W2982351196 @default.
- W3136840282 cites W2982639099 @default.
- W3136840282 cites W2982941009 @default.
- W3136840282 cites W2985184075 @default.
- W3136840282 cites W2993396177 @default.
- W3136840282 cites W2997651623 @default.
- W3136840282 cites W3000973849 @default.
- W3136840282 cites W3002119942 @default.
- W3136840282 cites W3004406522 @default.
- W3136840282 cites W3005084630 @default.
- W3136840282 cites W3006011131 @default.
- W3136840282 cites W3010553312 @default.
- W3136840282 cites W3012853516 @default.
- W3136840282 cites W3017437165 @default.
- W3136840282 cites W3021780675 @default.
- W3136840282 cites W3023447350 @default.
- W3136840282 cites W3025076654 @default.
- W3136840282 cites W3040417640 @default.
- W3136840282 cites W3045107785 @default.
- W3136840282 cites W3045436654 @default.
- W3136840282 cites W3045511683 @default.
- W3136840282 cites W3046187348 @default.
- W3136840282 cites W3047090302 @default.
- W3136840282 cites W3047609777 @default.
- W3136840282 cites W3047714350 @default.
- W3136840282 cites W3047768417 @default.
- W3136840282 cites W3047860431 @default.
- W3136840282 cites W3048582256 @default.
- W3136840282 cites W3071431406 @default.
- W3136840282 cites W3080520799 @default.
- W3136840282 cites W3081298078 @default.
- W3136840282 cites W3094620709 @default.
- W3136840282 cites W3096185915 @default.
- W3136840282 cites W3117532134 @default.
- W3136840282 cites W4213373616 @default.
- W3136840282 doi "https://doi.org/10.1002/adfm.202009924" @default.
- W3136840282 hasPublicationYear "2021" @default.
- W3136840282 type Work @default.
- W3136840282 sameAs 3136840282 @default.
- W3136840282 citedByCount "54" @default.
- W3136840282 countsByYear W31368402822021 @default.
- W3136840282 countsByYear W31368402822022 @default.
- W3136840282 countsByYear W31368402822023 @default.
- W3136840282 crossrefType "journal-article" @default.
- W3136840282 hasAuthorship W3136840282A5000103532 @default.
- W3136840282 hasAuthorship W3136840282A5023493981 @default.