FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136852746> ?p ?o ?g. }

• W3136852746 abstract "The oleaginous yeast Yarrowia lipolytica is a potent cell factory as it is able to use a wide variety of carbon sources to convert waste materials into value-added products. Nonetheless, there are still gaps in our understanding of its central carbon metabolism. Here we present an in-depth study of Y. lipolytica hexokinase (YlHxk1), a structurally unique protein. The greatest peculiarity of YlHxk1 is a 37-amino acid loop region, a structure not found in any other known hexokinases. By combining bioinformatic and experimental methods we showed that the loop in YlHxk1 is essential for activity of this protein and through that on growth of Y. lipolytica on glucose and fructose. We further proved that the loop in YlHxk1 hinders binding with trehalose 6-phosphate (T6P), a glycolysis inhibitor, as hexokinase with partial deletion of this region is 4.7-fold less sensitive to this molecule. We also found that YlHxk1 devoid of the loop causes strong repressive effect on lipase-encoding genes LIP2 and LIP8 and that the hexokinase overexpression in Y. lipolytica changes glycerol over glucose preference when cultivated in media containing both substrates." @default.
• W3136852746 created "2021-03-29" @default.
• W3136852746 creator A5009695168 @default.
• W3136852746 creator A5033407625 @default.
• W3136852746 creator A5037633982 @default.
• W3136852746 creator A5045926373 @default.
• W3136852746 date "2021-03-19" @default.
• W3136852746 modified "2023-09-30" @default.
• W3136852746 title "A 37-amino acid loop in the Yarrowia lipolytica hexokinase impacts its activity and affinity and modulates gene expression" @default.
• W3136852746 cites W1531686745 @default.
• W3136852746 cites W1984162154 @default.
• W3136852746 cites W1997814644 @default.
• W3136852746 cites W2000168109 @default.
• W3136852746 cites W2003290224 @default.
• W3136852746 cites W2008497254 @default.
• W3136852746 cites W2014820989 @default.
• W3136852746 cites W2016894196 @default.
• W3136852746 cites W2018779710 @default.
• W3136852746 cites W2025140569 @default.
• W3136852746 cites W2025505237 @default.
• W3136852746 cites W2029603384 @default.
• W3136852746 cites W2034178379 @default.
• W3136852746 cites W2043508542 @default.
• W3136852746 cites W2049965804 @default.
• W3136852746 cites W2055043387 @default.
• W3136852746 cites W2055400075 @default.
• W3136852746 cites W2062910508 @default.
• W3136852746 cites W2065020478 @default.
• W3136852746 cites W2075122775 @default.
• W3136852746 cites W2084997768 @default.
• W3136852746 cites W2089782157 @default.
• W3136852746 cites W2096525273 @default.
• W3136852746 cites W2109837531 @default.
• W3136852746 cites W2114927367 @default.
• W3136852746 cites W2120772351 @default.
• W3136852746 cites W2122062310 @default.
• W3136852746 cites W2127322768 @default.
• W3136852746 cites W2128635872 @default.
• W3136852746 cites W2134415009 @default.
• W3136852746 cites W2142690324 @default.
• W3136852746 cites W2147451073 @default.
• W3136852746 cites W2158884436 @default.
• W3136852746 cites W2165418074 @default.
• W3136852746 cites W2170568766 @default.
• W3136852746 cites W2311203695 @default.
• W3136852746 cites W2339769943 @default.
• W3136852746 cites W2734293393 @default.
• W3136852746 cites W2804822363 @default.
• W3136852746 cites W2940968218 @default.
• W3136852746 cites W2974727321 @default.
• W3136852746 cites W2999806901 @default.
• W3136852746 cites W3020679449 @default.
• W3136852746 cites W3027695786 @default.
• W3136852746 cites W3030585546 @default.
• W3136852746 cites W3045571007 @default.
• W3136852746 cites W3082959088 @default.
• W3136852746 cites W4248735723 @default.
• W3136852746 cites W4293247451 @default.
• W3136852746 doi "https://doi.org/10.1038/s41598-021-85837-8" @default.
• W3136852746 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7979807" @default.
• W3136852746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33742083" @default.
• W3136852746 hasPublicationYear "2021" @default.
• W3136852746 type Work @default.
• W3136852746 sameAs 3136852746 @default.
• W3136852746 citedByCount "7" @default.
• W3136852746 countsByYear W31368527462021 @default.
• W3136852746 countsByYear W31368527462022 @default.
• W3136852746 countsByYear W31368527462023 @default.
• W3136852746 crossrefType "journal-article" @default.
• W3136852746 hasAuthorship W3136852746A5009695168 @default.
• W3136852746 hasAuthorship W3136852746A5033407625 @default.
• W3136852746 hasAuthorship W3136852746A5037633982 @default.
• W3136852746 hasAuthorship W3136852746A5045926373 @default.
• W3136852746 hasBestOaLocation W31368527461 @default.
• W3136852746 hasConcept C104317684 @default.
• W3136852746 hasConcept C181199279 @default.
• W3136852746 hasConcept C185592680 @default.
• W3136852746 hasConcept C20251656 @default.
• W3136852746 hasConcept C2776970464 @default.
• W3136852746 hasConcept C2778452849 @default.
• W3136852746 hasConcept C2779222958 @default.
• W3136852746 hasConcept C2779490540 @default.
• W3136852746 hasConcept C2779826832 @default.
• W3136852746 hasConcept C2780282346 @default.
• W3136852746 hasConcept C515207424 @default.
• W3136852746 hasConcept C55493867 @default.
• W3136852746 hasConcept C86803240 @default.
• W3136852746 hasConceptScore W3136852746C104317684 @default.
• W3136852746 hasConceptScore W3136852746C181199279 @default.
• W3136852746 hasConceptScore W3136852746C185592680 @default.
• W3136852746 hasConceptScore W3136852746C20251656 @default.
• W3136852746 hasConceptScore W3136852746C2776970464 @default.
• W3136852746 hasConceptScore W3136852746C2778452849 @default.
• W3136852746 hasConceptScore W3136852746C2779222958 @default.
• W3136852746 hasConceptScore W3136852746C2779490540 @default.
• W3136852746 hasConceptScore W3136852746C2779826832 @default.
• W3136852746 hasConceptScore W3136852746C2780282346 @default.
• W3136852746 hasConceptScore W3136852746C515207424 @default.
• W3136852746 hasConceptScore W3136852746C55493867 @default.
• W3136852746 hasConceptScore W3136852746C86803240 @default.

• next