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- W3136875435 abstract "Gender-specific care throughout hematopoietic stem cell transplantation (HSCT) covers all aspects of reproductive and sexual health, with the goal of early detection and prevention of disease to reduce morbidity and mortality. Gonadal insufficiency in females often results in premature primary ovarian insufficiency following exposure to cytotoxic drugs and total body irradiation. Menstrual suppression in post-pubertal adolescents and women can mitigate thrombocytopenia-associated menorrhagia arising from the conditioning regimen for HSCT. Small studies of potential options for ovarian protection are being performed in animals, including using mTOR inhibitors, which may block a pathway in ovarian apoptosis. Discussion about fertility after treatment and options for fertility preservation has become standard of care within the pretransplant evaluation and cancer care worldwide, as infertility can cause significant psychological distress and affect quality of life posttransplant. Men and their partners are advised to use contraception especially during at least the first 100 days after transplant." @default.
- W3136875435 created "2021-03-29" @default.
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- W3136875435 date "2021-03-19" @default.
- W3136875435 modified "2023-10-13" @default.
- W3136875435 title "Pretransplant considerations in gender, reproductive, and sexual health" @default.
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- W3136875435 doi "https://doi.org/10.1002/9781119612780.ch20" @default.
- W3136875435 hasPublicationYear "2021" @default.
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