Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136904408> ?p ?o ?g. }
- W3136904408 abstract "Abstract Jak3 is the only non-promiscuous member of the Jak family of secondary messengers. Studies to date have focused on understanding and targeting the cell-autonomous role of Jak3 in immunity, while functional Jak3 expression outside the hematopoietic system remains largely unreported. We show that Jak3 is expressed in endothelial cells across hematopoietic and non-hematopoietic organs, with heightened expression in the bone marrow. The bone marrow niche is understood as a network of different cell types that regulate hematopoietic function. We show that the Jak3 –/– bone marrow niche is deleterious for the maintenance of long-term repopulating hematopoietic stem cells (LT-HSCs) and that JAK3 -overexpressing endothelial cells have increased potential to expand LT-HSCs in vitro. This work may serve to identify a novel function for a highly specific tyrosine kinase in the bone marrow vascular niche and to further characterize the LT-HSC function of sinusoidal endothelium." @default.
- W3136904408 created "2021-03-29" @default.
- W3136904408 creator A5027677100 @default.
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- W3136904408 creator A5090799132 @default.
- W3136904408 date "2021-03-25" @default.
- W3136904408 modified "2023-10-03" @default.
- W3136904408 title "Endothelial Jak3 expression enhances pro-hematopoietic angiocrine function in mice" @default.
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