Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136908382> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W3136908382 endingPage "19" @default.
- W3136908382 startingPage "3" @default.
- W3136908382 abstract "Although monoamine-based pharmacological drugs revolutionized the treatment of major depressive disorder, about one third of patients experience treatment-resistant depression. Thus, development of antidepressant with novel mechanism is required. In this study, we investigated the involvement of microsomal prostaglandin E synthase-1 (mPGES-1), a terminal inducible enzyme for PGE2 synthesis, in acute restraint stress (RS: 6 hr) and social defeat stress (SDS: 1 day). mPGES-1 mRNA was significantly increased after RS. Induction of mPGES-1 protein was observed in neurons in the frontal cortex (FC). PGE2 in FC was also significantly upregulated in wild-type (WT) mice, but not in mPGES-1 knockout (ES1KO) mice. The inflammatory responses, such as increases in GFAP and TNF-α, observed after RS in ES1KO were significantly less than those in WT. After RS, there were no significant differences between WT and ES1KO in open field test (OFT), forced swimming test, elevated plus maze test (EPM) and marble burying test. On the other hand, in sucrose preference test, the ratio of sucrose intake after RS in WT was significantly less than that in ES1KO. In acute SDS model, social avoidance behavior was significantly observed after SDS. At the same time, upregulation of mPGES-1 was also observed in FC, amygdala and ventral tegmental area. Taken together, these results suggest that mPGES-1 is induced by acute stress in FC, and then contributes to brain inflammation and anhedonia through PGE2 production. Thus, mPGSE-1 may be a promising novel therapeutic target for depression." @default.
- W3136908382 created "2021-03-29" @default.
- W3136908382 creator A5018553332 @default.
- W3136908382 creator A5027066586 @default.
- W3136908382 creator A5034201355 @default.
- W3136908382 creator A5037325452 @default.
- W3136908382 creator A5045524463 @default.
- W3136908382 creator A5051593432 @default.
- W3136908382 creator A5078394318 @default.
- W3136908382 creator A5082930422 @default.
- W3136908382 date "2021-01-01" @default.
- W3136908382 modified "2023-09-26" @default.
- W3136908382 title "Role of Microsomal prostaglandin E synthase-1 in acute stress" @default.
- W3136908382 doi "https://doi.org/10.1254/jpssuppl.94.0_3-p1-19" @default.
- W3136908382 hasPublicationYear "2021" @default.
- W3136908382 type Work @default.
- W3136908382 sameAs 3136908382 @default.
- W3136908382 citedByCount "0" @default.
- W3136908382 crossrefType "journal-article" @default.
- W3136908382 hasAuthorship W3136908382A5018553332 @default.
- W3136908382 hasAuthorship W3136908382A5027066586 @default.
- W3136908382 hasAuthorship W3136908382A5034201355 @default.
- W3136908382 hasAuthorship W3136908382A5037325452 @default.
- W3136908382 hasAuthorship W3136908382A5045524463 @default.
- W3136908382 hasAuthorship W3136908382A5051593432 @default.
- W3136908382 hasAuthorship W3136908382A5078394318 @default.
- W3136908382 hasAuthorship W3136908382A5082930422 @default.
- W3136908382 hasBestOaLocation W31369083821 @default.
- W3136908382 hasConcept C104317684 @default.
- W3136908382 hasConcept C126322002 @default.
- W3136908382 hasConcept C127561419 @default.
- W3136908382 hasConcept C134018914 @default.
- W3136908382 hasConcept C136569192 @default.
- W3136908382 hasConcept C170493617 @default.
- W3136908382 hasConcept C185592680 @default.
- W3136908382 hasConcept C187714386 @default.
- W3136908382 hasConcept C2775864247 @default.
- W3136908382 hasConcept C2777198256 @default.
- W3136908382 hasConcept C2778941446 @default.
- W3136908382 hasConcept C2779085643 @default.
- W3136908382 hasConcept C2779177272 @default.
- W3136908382 hasConcept C2781001258 @default.
- W3136908382 hasConcept C2781161787 @default.
- W3136908382 hasConcept C513476851 @default.
- W3136908382 hasConcept C55493867 @default.
- W3136908382 hasConcept C71924100 @default.
- W3136908382 hasConceptScore W3136908382C104317684 @default.
- W3136908382 hasConceptScore W3136908382C126322002 @default.
- W3136908382 hasConceptScore W3136908382C127561419 @default.
- W3136908382 hasConceptScore W3136908382C134018914 @default.
- W3136908382 hasConceptScore W3136908382C136569192 @default.
- W3136908382 hasConceptScore W3136908382C170493617 @default.
- W3136908382 hasConceptScore W3136908382C185592680 @default.
- W3136908382 hasConceptScore W3136908382C187714386 @default.
- W3136908382 hasConceptScore W3136908382C2775864247 @default.
- W3136908382 hasConceptScore W3136908382C2777198256 @default.
- W3136908382 hasConceptScore W3136908382C2778941446 @default.
- W3136908382 hasConceptScore W3136908382C2779085643 @default.
- W3136908382 hasConceptScore W3136908382C2779177272 @default.
- W3136908382 hasConceptScore W3136908382C2781001258 @default.
- W3136908382 hasConceptScore W3136908382C2781161787 @default.
- W3136908382 hasConceptScore W3136908382C513476851 @default.
- W3136908382 hasConceptScore W3136908382C55493867 @default.
- W3136908382 hasConceptScore W3136908382C71924100 @default.
- W3136908382 hasIssue "0" @default.
- W3136908382 hasLocation W31369083821 @default.
- W3136908382 hasOpenAccess W3136908382 @default.
- W3136908382 hasPrimaryLocation W31369083821 @default.
- W3136908382 hasRelatedWork W1976696124 @default.
- W3136908382 hasRelatedWork W2039909707 @default.
- W3136908382 hasRelatedWork W2103314312 @default.
- W3136908382 hasRelatedWork W2215225540 @default.
- W3136908382 hasRelatedWork W2354942730 @default.
- W3136908382 hasRelatedWork W2389809408 @default.
- W3136908382 hasRelatedWork W3084191455 @default.
- W3136908382 hasRelatedWork W4246106067 @default.
- W3136908382 hasRelatedWork W4287921518 @default.
- W3136908382 hasRelatedWork W2181863213 @default.
- W3136908382 hasVolume "94" @default.
- W3136908382 isParatext "false" @default.
- W3136908382 isRetracted "false" @default.
- W3136908382 magId "3136908382" @default.
- W3136908382 workType "article" @default.