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- W3136913023 endingPage "120492" @default.
- W3136913023 startingPage "120492" @default.
- W3136913023 abstract "In this study, the molecular state of ritonavir (RTN)-saccharin (SAC) coamorphous incorporated into mesoporous silica by solvent evaporation and the effect of SAC on the RTN dissolution from mesopores were investigated. The amorphization of RTN-SAC was confirmed as a halo pattern in powder X-ray diffraction measurements and a single glass transition event in the modulated differential scanning calorimetry (MDSC) curve. 13C solid-state NMR spectroscopy revealed a hydrogen bond between the thiazole nitrogen of RTN and the amine proton of SAC. The glass transition of the RTN-SAC coamorphous in mesoporous silica was not found in the MDSC curve, indicating that RTN and SAC were monomolecularly incorporated into the mesopores. Solid-state NMR measurements suggested that the co-incorporation of SAC into the mesopores decreased the local mobility of the thiazole group of RTN via hydrogen bond formation. The RTN-SAC 1:1 coamorphous in mesoporous silica retained the X-ray halo-patterns after 30 d of storage, even under high temperature and humidity conditions. In the dissolution test, the RTN-SAC 1:1 coamorphous in mesoporous silica maintained RTN supersaturation for a longer time than the RTN amorphous in mesoporous silica. This study demonstrated that the drug-coformer interaction within mesoporous silica can significantly improve drug dissolution." @default.
- W3136913023 created "2021-03-29" @default.
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- W3136913023 date "2021-05-01" @default.
- W3136913023 modified "2023-09-26" @default.
- W3136913023 title "Effect of drug-coformer interactions on drug dissolution from a coamorphous in mesoporous silica" @default.
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- W3136913023 doi "https://doi.org/10.1016/j.ijpharm.2021.120492" @default.
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