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- W3136924260 endingPage "528" @default.
- W3136924260 startingPage "528" @default.
- W3136924260 abstract "SUMOylation is a highly dynamic ubiquitin-like post-translational modification that is essential for cells to respond to and resolve various genotoxic and proteotoxic stresses. Virus infections also constitute a considerable stress scenario for cells, and recent research has started to uncover the diverse roles of SUMOylation in regulating virus replication, not least by impacting antiviral defenses. Here, we review some of the key findings of this virus-host interplay, and discuss the increasingly important contribution that large-scale, unbiased, proteomic methodologies are making to discoveries in this field. We highlight the latest proteomic technologies that have been specifically developed to understand SUMOylation dynamics in response to cellular stresses, and comment on how these techniques might be best applied to dissect the biology of SUMOylation during innate immunity. Furthermore, we showcase a selection of studies that have already used SUMO proteomics to reveal novel aspects of host innate defense against viruses, such as functional cross-talk between SUMO proteins and other ubiquitin-like modifiers, viral antagonism of SUMO-modified antiviral restriction factors, and an infection-triggered SUMO-switch that releases endogenous retroelement RNAs to stimulate antiviral interferon responses. Future research in this area has the potential to provide new and diverse mechanistic insights into host immune defenses." @default.
- W3136924260 created "2021-03-29" @default.
- W3136924260 creator A5001177257 @default.
- W3136924260 creator A5013954149 @default.
- W3136924260 creator A5014290505 @default.
- W3136924260 date "2021-03-23" @default.
- W3136924260 modified "2023-09-26" @default.
- W3136924260 title "Proteomic Approaches to Dissect Host SUMOylation during Innate Antiviral Immune Responses" @default.
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