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- W3136947213 abstract "INTRODUCTION:Serious bacterial infection is common in infants and children. Many children with serious bacterial infection at presentation have no identifiable cause other than fever. Simple, rapid inexpensive diagnostic test that identify serious bacterial infection among febrile children is unattainable. Reactive thrombocytosis secondary to infection is a common finding in children. Platelet will behave as an acute phase reactant through the stimulation of platelet production by Interleukin-6.AIM OF THE STUDY: 1. To estimate the incidence of reactive thrombocytosis among young infants and children with serious bacterial infection. 2. To assess the utility of platelet count as a potential predictor of serious bacterial infection.METHODS:It was a prospective study conducted on infants and children aged between 2 months and 3 years admitted as inpatients in PICU and IMCU of the Pediatric department in Tirunelveli Medical College and Hospital during May 1, 2018 to April 30, 2019.RESULTS: The general incidence of thrombocytosis was 42% in children with febrile illness. In children with thrombocytosis, 53.6% had SBI. Among children with SBI, 80% had thrombocytosis. In babies with non SBI, only 27.1% had thrombocytosis. The P value was statistically significant when the platelet count was compared between SBI and non SBI group. The mean platelet count was higher in SBI group. P value showed statistical significance between mean platelet count in SBI and non SBI group. The sensitivity and specificity of platelet in diagnosing SBI was 80.4% and 72% respectively. Other parameters that helps in early recognition of febrile infants at risk of serious bacterial infection are total WBC count, CRP, pyuria.CONCLUSION: The incidence of thrombocytosis was high in babies with SBI. Among babies with SBI, 80.3% had thrombocytosis. In babies with non SBI, only 27.1% had thrombocytosis. Thus thrombocytosis can be used as a predictor of serious bacterial infection." @default.
- W3136947213 created "2021-03-29" @default.
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- W3136947213 date "2020-05-01" @default.
- W3136947213 modified "2023-09-24" @default.
- W3136947213 title "Reactive Thrombocytosis in Febrile Infants and Children with Serious Bacterial Infection" @default.
- W3136947213 hasPublicationYear "2020" @default.
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