Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136961378> ?p ?o ?g. }
- W3136961378 endingPage "147" @default.
- W3136961378 startingPage "139" @default.
- W3136961378 abstract "The emergence and course of major depressive disorders (MDD) show a clear causal relationship with the dysregulation and dysfunction of the immune system. Systemic and neural low-grade chronic or acute inflammation initiates and perpetuates MDD psychopathology. Proinflammatory factors, released into the circulation by brain-intrinsic immune regulatory cells (microglia and astroglia) and immune cells entering the CNS (T- and B-cells, neutrophils, dendritic cells, etc.) trigger changes in neural circuits and function. Chronic stress, which strongly contributes to MDD, is known to suppress protective immune responses and/or exacerbate pathological immune responses. Thus, inflammatory mediators (interleukins and cytokines) form the interface between psychological stress, depressive symptomatology, and immunological processes. Inflammasomes are intracellular multiprotein signaling platforms critical for the orchestration of innate immune and inflammatory responses. These proteins sense the pathophysiological environment and produce proinflammatory cytokines. Recent studies highlight the importance of inflammasomes for MDD pathophysiology. Therefore, understanding the role of inflammasomes and their regulation could provide novel therapeutic options for MDD." @default.
- W3136961378 created "2021-03-29" @default.
- W3136961378 creator A5040251951 @default.
- W3136961378 creator A5088104480 @default.
- W3136961378 date "2021-01-01" @default.
- W3136961378 modified "2023-09-25" @default.
- W3136961378 title "Brain inflammasomes in depression" @default.
- W3136961378 cites W1568964113 @default.
- W3136961378 cites W1666339910 @default.
- W3136961378 cites W1870318731 @default.
- W3136961378 cites W1883758818 @default.
- W3136961378 cites W1915977580 @default.
- W3136961378 cites W1936565989 @default.
- W3136961378 cites W1964744961 @default.
- W3136961378 cites W1969539443 @default.
- W3136961378 cites W1975256977 @default.
- W3136961378 cites W1981590577 @default.
- W3136961378 cites W1981649246 @default.
- W3136961378 cites W1987557377 @default.
- W3136961378 cites W1993976394 @default.
- W3136961378 cites W1995939440 @default.
- W3136961378 cites W1996667083 @default.
- W3136961378 cites W2003062523 @default.
- W3136961378 cites W2005886168 @default.
- W3136961378 cites W2021654198 @default.
- W3136961378 cites W2059172386 @default.
- W3136961378 cites W2062682953 @default.
- W3136961378 cites W2065802840 @default.
- W3136961378 cites W2066906062 @default.
- W3136961378 cites W2068185520 @default.
- W3136961378 cites W2069809946 @default.
- W3136961378 cites W2072016770 @default.
- W3136961378 cites W2077672919 @default.
- W3136961378 cites W2078847756 @default.
- W3136961378 cites W2079320514 @default.
- W3136961378 cites W2082793902 @default.
- W3136961378 cites W2088546194 @default.
- W3136961378 cites W2100938689 @default.
- W3136961378 cites W2100953877 @default.
- W3136961378 cites W2106623141 @default.
- W3136961378 cites W2113511371 @default.
- W3136961378 cites W2119707412 @default.
- W3136961378 cites W2121560754 @default.
- W3136961378 cites W2122192348 @default.
- W3136961378 cites W2122828560 @default.
- W3136961378 cites W2129579709 @default.
- W3136961378 cites W2192342554 @default.
- W3136961378 cites W2201607793 @default.
- W3136961378 cites W2206933179 @default.
- W3136961378 cites W2239409567 @default.
- W3136961378 cites W2302151110 @default.
- W3136961378 cites W2314124374 @default.
- W3136961378 cites W2340747659 @default.
- W3136961378 cites W2416643466 @default.
- W3136961378 cites W2478122494 @default.
- W3136961378 cites W2492083962 @default.
- W3136961378 cites W2494440271 @default.
- W3136961378 cites W2519531315 @default.
- W3136961378 cites W2521723708 @default.
- W3136961378 cites W2553156636 @default.
- W3136961378 cites W2559702793 @default.
- W3136961378 cites W2579986869 @default.
- W3136961378 cites W2589128164 @default.
- W3136961378 cites W2593489095 @default.
- W3136961378 cites W2605685784 @default.
- W3136961378 cites W2610137145 @default.
- W3136961378 cites W2610408698 @default.
- W3136961378 cites W2611320193 @default.
- W3136961378 cites W2744911582 @default.
- W3136961378 cites W2769599719 @default.
- W3136961378 cites W2787368117 @default.
- W3136961378 cites W2789124288 @default.
- W3136961378 cites W2790672499 @default.
- W3136961378 cites W2793814631 @default.
- W3136961378 cites W2803513074 @default.
- W3136961378 cites W2808641706 @default.
- W3136961378 cites W2884443283 @default.
- W3136961378 cites W2885580638 @default.
- W3136961378 cites W2887287828 @default.
- W3136961378 cites W2890670389 @default.
- W3136961378 cites W2892919725 @default.
- W3136961378 cites W2898500156 @default.
- W3136961378 cites W2908045260 @default.
- W3136961378 cites W2913004193 @default.
- W3136961378 cites W2937313492 @default.
- W3136961378 cites W2941630117 @default.
- W3136961378 cites W2945038546 @default.
- W3136961378 cites W2953025937 @default.
- W3136961378 cites W2960722412 @default.
- W3136961378 cites W2982045176 @default.
- W3136961378 cites W3030316505 @default.
- W3136961378 cites W4211217520 @default.
- W3136961378 doi "https://doi.org/10.1016/b978-0-12-817935-2.00036-2" @default.
- W3136961378 hasPublicationYear "2021" @default.
- W3136961378 type Work @default.
- W3136961378 sameAs 3136961378 @default.
- W3136961378 citedByCount "1" @default.
- W3136961378 countsByYear W31369613782022 @default.