FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136972677> ?p ?o ?g. }

• W3136972677 endingPage "100545" @default.
• W3136972677 startingPage "100545" @default.
• W3136972677 abstract "Transforming growth factor-β (TGF-β) signaling promotes cancer progression. In particular, the epithelial–mesenchymal transition (EMT) induced by TGF-β is considered crucial to the malignant phenotype of cancer cells. Here, we report that the EMT-associated cellular responses induced by TGF-β are mediated by distinct signaling pathways that diverge at Smad3. By expressing chimeric Smad1/Smad3 proteins in <i>SMAD3</i> knockout A549 cells, we found that the β4 region in the Smad3 MH1 domain is essential for TGF-β-induced cell motility, but is not essential for other EMT-associated responses including epithelial marker downregulation. TGF-β was previously reported to enhance cell motility by activating Rac1 <i>via</i> phosphoinositide 3-kinase. Intriguingly, TGF-β-dependent signaling mediated by Smad3's β4 region causes the downregulation of multiple mRNAs that encode GTPase activating proteins that target Rac1 (<i>ARHGAP</i>s), thereby attenuating Rac1 inactivation. Therefore, two independent pathways downstream of TGF-β type I receptor contribute cooperatively to sustained Rac1 activation, thereby leading to enhanced cell motility." @default.
• W3136972677 created "2021-03-29" @default.
• W3136972677 creator A5015088286 @default.
• W3136972677 creator A5016716688 @default.
• W3136972677 creator A5018918485 @default.
• W3136972677 creator A5042913325 @default.
• W3136972677 creator A5051009186 @default.
• W3136972677 creator A5052973866 @default.
• W3136972677 creator A5066010228 @default.
• W3136972677 creator A5081231451 @default.
• W3136972677 date "2021-01-01" @default.
• W3136972677 modified "2023-10-12" @default.
• W3136972677 title "TGF-β-induced cell motility requires downregulation of ARHGAPs to sustain Rac1 activity" @default.
• W3136972677 cites W1017756713 @default.
• W3136972677 cites W1547191505 @default.
• W3136972677 cites W1556496855 @default.
• W3136972677 cites W1574220082 @default.
• W3136972677 cites W1968783143 @default.
• W3136972677 cites W1968826282 @default.
• W3136972677 cites W1971801835 @default.
• W3136972677 cites W1983628734 @default.
• W3136972677 cites W1984086927 @default.
• W3136972677 cites W1984162437 @default.
• W3136972677 cites W1988498329 @default.
• W3136972677 cites W1997472202 @default.
• W3136972677 cites W2000742696 @default.
• W3136972677 cites W2001873993 @default.
• W3136972677 cites W2007444505 @default.
• W3136972677 cites W2008869198 @default.
• W3136972677 cites W2009410973 @default.
• W3136972677 cites W2016809143 @default.
• W3136972677 cites W2021856025 @default.
• W3136972677 cites W2034342175 @default.
• W3136972677 cites W2040793666 @default.
• W3136972677 cites W2067785100 @default.
• W3136972677 cites W2069381751 @default.
• W3136972677 cites W2077728054 @default.
• W3136972677 cites W2093226717 @default.
• W3136972677 cites W2102868284 @default.
• W3136972677 cites W2103919722 @default.
• W3136972677 cites W2111391000 @default.
• W3136972677 cites W2113111638 @default.
• W3136972677 cites W2116577936 @default.
• W3136972677 cites W2127690474 @default.
• W3136972677 cites W2131464048 @default.
• W3136972677 cites W2144813778 @default.
• W3136972677 cites W2154154147 @default.
• W3136972677 cites W2154568166 @default.
• W3136972677 cites W2161186807 @default.
• W3136972677 cites W2163595132 @default.
• W3136972677 cites W2166678824 @default.
• W3136972677 cites W2197993712 @default.
• W3136972677 cites W2408875255 @default.
• W3136972677 cites W2510652998 @default.
• W3136972677 cites W2610089186 @default.
• W3136972677 cites W2730407871 @default.
• W3136972677 cites W2769365148 @default.
• W3136972677 cites W2799324362 @default.
• W3136972677 cites W2888558340 @default.
• W3136972677 cites W2900585188 @default.
• W3136972677 cites W2925810998 @default.
• W3136972677 cites W2972151198 @default.
• W3136972677 cites W3000568230 @default.
• W3136972677 cites W3012860965 @default.
• W3136972677 cites W3016840787 @default.
• W3136972677 cites W3024330383 @default.
• W3136972677 cites W4211233744 @default.
• W3136972677 doi "https://doi.org/10.1016/j.jbc.2021.100545" @default.
• W3136972677 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8079281" @default.
• W3136972677 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33741342" @default.
• W3136972677 hasPublicationYear "2021" @default.
• W3136972677 type Work @default.
• W3136972677 sameAs 3136972677 @default.
• W3136972677 citedByCount "3" @default.
• W3136972677 countsByYear W31369726772021 @default.
• W3136972677 countsByYear W31369726772022 @default.
• W3136972677 countsByYear W31369726772023 @default.
• W3136972677 crossrefType "journal-article" @default.
• W3136972677 hasAuthorship W3136972677A5015088286 @default.
• W3136972677 hasAuthorship W3136972677A5016716688 @default.
• W3136972677 hasAuthorship W3136972677A5018918485 @default.
• W3136972677 hasAuthorship W3136972677A5042913325 @default.
• W3136972677 hasAuthorship W3136972677A5051009186 @default.
• W3136972677 hasAuthorship W3136972677A5052973866 @default.
• W3136972677 hasAuthorship W3136972677A5066010228 @default.
• W3136972677 hasAuthorship W3136972677A5081231451 @default.
• W3136972677 hasBestOaLocation W31369726771 @default.
• W3136972677 hasConcept C104317684 @default.
• W3136972677 hasConcept C118131993 @default.
• W3136972677 hasConcept C127561419 @default.
• W3136972677 hasConcept C137738243 @default.
• W3136972677 hasConcept C1491633281 @default.
• W3136972677 hasConcept C185592680 @default.
• W3136972677 hasConcept C2778229498 @default.
• W3136972677 hasConcept C2779717556 @default.
• W3136972677 hasConcept C502942594 @default.
• W3136972677 hasConcept C55493867 @default.
• W3136972677 hasConcept C58207958 @default.

• next