FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136985141> ?p ?o ?g. }

• W3136985141 endingPage "107525" @default.
• W3136985141 startingPage "107525" @default.
• W3136985141 abstract "Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease limited to the lungs. Immunological dysregulation may significantly participate in the pathophysiology of IPF. The immunological responses to nintedanib therapy in IPF patients were investigated for the first time in this study. Materials and methods Fifty IPF patients (median age (IQR) 69 (65–75) years; 38 males), were selected retrospectively. Flowcytometry analysis were performed to phenotype immunological biomarkers in peripheral blood from IPF patients after 1 year of antifibrotic therapy and a group of healthy volunteers. Results Before starting antifibrotic treatment, IPF patients showed increased CD1d+CD5+ (p = 0.0460), Treg (p = 0.0354), T effector (CD25highCD127high) (p = 0.0336), central cells (CD4+CD45RA−) (p = 0.0354), effector cells (CD4+CD45RA+) (p = 0.0249) and follicular cell percentages (p = 0.0006), notably Tfh1 (p = 0.0412) and Tfh17 (p = 0.0051) cell percentages, in respect with healthy controls (HC). After nintedanib therapy, Breg (p = 0.0302), T effector (p = 0.0468), Th17.1 (p = 0.0146) and follicular cells (p = 0.0006), notably Tfh1 (p = 0.0006) and Tfh17 (p = 0.0182) cell percentages, were significantly decreased. In the logistic regression, Tfh panel showed a significant area under the receiver operating characteristics curve (AUROC) to distinguish IPF than HC (90.5%), as well as t0 and t1 (99.3%). Conclusion In conclusion, the immunological results obtained in this study demonstrate that nintedanib significantly helps to restore immunological responses in IPF patients. These findings will be useful in the search for biomarkers predictive of response to antifibrotic treatment." @default.
• W3136985141 created "2021-03-29" @default.
• W3136985141 creator A5001098559 @default.
• W3136985141 creator A5010151861 @default.
• W3136985141 creator A5012536832 @default.
• W3136985141 creator A5013985509 @default.
• W3136985141 creator A5027529004 @default.
• W3136985141 creator A5033753974 @default.
• W3136985141 creator A5045093097 @default.
• W3136985141 creator A5056577312 @default.
• W3136985141 creator A5082781749 @default.
• W3136985141 creator A5083033878 @default.
• W3136985141 date "2021-06-01" @default.
• W3136985141 modified "2023-09-25" @default.
• W3136985141 title "Immunologic responses to antifibrotic treatment in IPF patients" @default.
• W3136985141 cites W1487631743 @default.
• W3136985141 cites W1983502838 @default.
• W3136985141 cites W1998562159 @default.
• W3136985141 cites W1998579865 @default.
• W3136985141 cites W2001775594 @default.
• W3136985141 cites W2002116270 @default.
• W3136985141 cites W2006236831 @default.
• W3136985141 cites W2009649694 @default.
• W3136985141 cites W2021110937 @default.
• W3136985141 cites W2025897582 @default.
• W3136985141 cites W2028001342 @default.
• W3136985141 cites W2028476437 @default.
• W3136985141 cites W2041647537 @default.
• W3136985141 cites W2046388159 @default.
• W3136985141 cites W2047234821 @default.
• W3136985141 cites W2047401978 @default.
• W3136985141 cites W2057099055 @default.
• W3136985141 cites W2060565525 @default.
• W3136985141 cites W2072853625 @default.
• W3136985141 cites W2081758257 @default.
• W3136985141 cites W2082871926 @default.
• W3136985141 cites W2095715691 @default.
• W3136985141 cites W2105937700 @default.
• W3136985141 cites W2111139868 @default.
• W3136985141 cites W2114970103 @default.
• W3136985141 cites W2121506712 @default.
• W3136985141 cites W2134342374 @default.
• W3136985141 cites W2142374046 @default.
• W3136985141 cites W2146604395 @default.
• W3136985141 cites W2147450297 @default.
• W3136985141 cites W2150969530 @default.
• W3136985141 cites W2152014155 @default.
• W3136985141 cites W2156964052 @default.
• W3136985141 cites W2191026300 @default.
• W3136985141 cites W2286883753 @default.
• W3136985141 cites W2312969713 @default.
• W3136985141 cites W2523177223 @default.
• W3136985141 cites W2554136262 @default.
• W3136985141 cites W2769414934 @default.
• W3136985141 cites W2772805131 @default.
• W3136985141 cites W2773049281 @default.
• W3136985141 cites W2790655533 @default.
• W3136985141 cites W2791214769 @default.
• W3136985141 cites W2889197569 @default.
• W3136985141 cites W2892890999 @default.
• W3136985141 cites W2898516278 @default.
• W3136985141 cites W2906126011 @default.
• W3136985141 cites W2912088702 @default.
• W3136985141 cites W2972032745 @default.
• W3136985141 cites W2983926462 @default.
• W3136985141 cites W3000798572 @default.
• W3136985141 cites W3007993053 @default.
• W3136985141 cites W3016298195 @default.
• W3136985141 cites W3023515998 @default.
• W3136985141 cites W3033017436 @default.
• W3136985141 cites W3036064217 @default.
• W3136985141 cites W3039388777 @default.
• W3136985141 cites W3046441947 @default.
• W3136985141 cites W3086896956 @default.
• W3136985141 cites W3094108029 @default.
• W3136985141 cites W3127760943 @default.
• W3136985141 cites W3127941900 @default.
• W3136985141 doi "https://doi.org/10.1016/j.intimp.2021.107525" @default.
• W3136985141 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33714885" @default.
• W3136985141 hasPublicationYear "2021" @default.
• W3136985141 type Work @default.
• W3136985141 sameAs 3136985141 @default.
• W3136985141 citedByCount "9" @default.
• W3136985141 countsByYear W31369851412021 @default.
• W3136985141 countsByYear W31369851412022 @default.
• W3136985141 countsByYear W31369851412023 @default.
• W3136985141 crossrefType "journal-article" @default.
• W3136985141 hasAuthorship W3136985141A5001098559 @default.
• W3136985141 hasAuthorship W3136985141A5010151861 @default.
• W3136985141 hasAuthorship W3136985141A5012536832 @default.
• W3136985141 hasAuthorship W3136985141A5013985509 @default.
• W3136985141 hasAuthorship W3136985141A5027529004 @default.
• W3136985141 hasAuthorship W3136985141A5033753974 @default.
• W3136985141 hasAuthorship W3136985141A5045093097 @default.
• W3136985141 hasAuthorship W3136985141A5056577312 @default.
• W3136985141 hasAuthorship W3136985141A5082781749 @default.
• W3136985141 hasAuthorship W3136985141A5083033878 @default.
• W3136985141 hasConcept C126322002 @default.

• next