FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136985572> ?p ?o ?g. }

• W3136985572 endingPage "947" @default.
• W3136985572 startingPage "937" @default.
• W3136985572 abstract "Primary immune thrombocytopenia (ITP) is defined as an acquired autoimmune disease characterized by isolated thrombocytopenia. This work is to further clarify the relationship between T cell immune dysfunction and the pathogenesis of ITP.37 adult patients with ITP were selected and were classified into newly diagnosed ITP (nITP, n = 13), persistent ITP (pITP, n = 6) and chronic ITP (cITP n = 18). The frequency of cytotoxic T lymphocytes (Tc1, Tc2, and Tc17) and helper T cells (Th1, Th2, and Th17), Tregs, and the expression of chemokine receptors and PD-1 on CD4+ T cells were investigated by flow cytometry. Plasma levels of T cell-related cytokines (IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ, IL-17) were measured by cytometric beads array (CBA).The percentage of Tc1 in cITP was greatly higher than nITP and healthy controls (p < 0.05, p < 0.01). The percentage of Treg in nITP and cITP groups was remarkably lower than those in healthy control group (p < 0.05, p < 0.001); and according to platelet count analysis (PLT<50x109/L or PLT>50x109/L), Treg cells in ITP group were significantly lower than those in healthy control group (p < 0.001, p < 0.05). The percentage of CD4+CXCR3+ of cITP was significantly higher than healthy controls and nITP (p < 0.01, p < 0.05). The percentage of CD4+CCR6+ in cITP was significantly higher than healthy controls and nITP (p < 0.001, p < 0.05). The expression of PD-1 in cITP patients was higher than healthy control (p < 0.05), but there was no significant difference among nITP, pITP and cITP (p = 0.25). The levels of IL-2, IFN-γ and TNFα in nITP group and cITP group were significantly higher than those in healthy control group (p < 0.01, p < 0.05; p < 0.01, p < 0.05; p < 0.05, p < 0.05), and the level of IL-10 in nITP group was significantly higher than that in pITP group (p < 0.05).Our results suggest that T lymphocyte immune dysfunction does exist in adult ITP patients and plays an important role in the pathogenesis of ITP." @default.
• W3136985572 created "2021-03-29" @default.
• W3136985572 creator A5020812487 @default.
• W3136985572 creator A5021997880 @default.
• W3136985572 creator A5024604872 @default.
• W3136985572 creator A5025568511 @default.
• W3136985572 creator A5033441324 @default.
• W3136985572 creator A5065091480 @default.
• W3136985572 creator A5066992539 @default.
• W3136985572 creator A5076832459 @default.
• W3136985572 date "2021-03-01" @default.
• W3136985572 modified "2023-10-09" @default.
• W3136985572 title "Imbalance of T Lymphocyte Subsets in Adult Immune Thrombocytopenia" @default.
• W3136985572 cites W1604738721 @default.
• W3136985572 cites W1945743078 @default.
• W3136985572 cites W1970574917 @default.
• W3136985572 cites W1972148206 @default.
• W3136985572 cites W2011497626 @default.
• W3136985572 cites W2012780133 @default.
• W3136985572 cites W2014129852 @default.
• W3136985572 cites W2014207233 @default.
• W3136985572 cites W2024490058 @default.
• W3136985572 cites W2026188624 @default.
• W3136985572 cites W2031652873 @default.
• W3136985572 cites W2032669080 @default.
• W3136985572 cites W2035185745 @default.
• W3136985572 cites W2040021588 @default.
• W3136985572 cites W2044781881 @default.
• W3136985572 cites W2050619107 @default.
• W3136985572 cites W2052378439 @default.
• W3136985572 cites W2053751923 @default.
• W3136985572 cites W2059418185 @default.
• W3136985572 cites W2074067501 @default.
• W3136985572 cites W2074850513 @default.
• W3136985572 cites W2076695066 @default.
• W3136985572 cites W2078349955 @default.
• W3136985572 cites W2079785691 @default.
• W3136985572 cites W2110106506 @default.
• W3136985572 cites W2122819371 @default.
• W3136985572 cites W2126497406 @default.
• W3136985572 cites W2129741568 @default.
• W3136985572 cites W2133210615 @default.
• W3136985572 cites W2142115110 @default.
• W3136985572 cites W2147579197 @default.
• W3136985572 cites W2161857859 @default.
• W3136985572 cites W2167810526 @default.
• W3136985572 cites W2168059411 @default.
• W3136985572 cites W2169973477 @default.
• W3136985572 cites W2170380431 @default.
• W3136985572 cites W2179965486 @default.
• W3136985572 cites W2202211699 @default.
• W3136985572 cites W2332183508 @default.
• W3136985572 cites W2335440988 @default.
• W3136985572 cites W252162786 @default.
• W3136985572 cites W2536559425 @default.
• W3136985572 cites W2586334726 @default.
• W3136985572 cites W2613164134 @default.
• W3136985572 cites W2615198393 @default.
• W3136985572 cites W2888764130 @default.
• W3136985572 cites W2900146534 @default.
• W3136985572 cites W2915920279 @default.
• W3136985572 cites W2947377592 @default.
• W3136985572 cites W2971488368 @default.
• W3136985572 doi "https://doi.org/10.2147/ijgm.s298888" @default.
• W3136985572 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7989055" @default.
• W3136985572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33776472" @default.
• W3136985572 hasPublicationYear "2021" @default.
• W3136985572 type Work @default.
• W3136985572 sameAs 3136985572 @default.
• W3136985572 citedByCount "6" @default.
• W3136985572 countsByYear W31369855722021 @default.
• W3136985572 countsByYear W31369855722022 @default.
• W3136985572 countsByYear W31369855722023 @default.
• W3136985572 crossrefType "journal-article" @default.
• W3136985572 hasAuthorship W3136985572A5020812487 @default.
• W3136985572 hasAuthorship W3136985572A5021997880 @default.
• W3136985572 hasAuthorship W3136985572A5024604872 @default.
• W3136985572 hasAuthorship W3136985572A5025568511 @default.
• W3136985572 hasAuthorship W3136985572A5033441324 @default.
• W3136985572 hasAuthorship W3136985572A5065091480 @default.
• W3136985572 hasAuthorship W3136985572A5066992539 @default.
• W3136985572 hasAuthorship W3136985572A5076832459 @default.
• W3136985572 hasBestOaLocation W31369855721 @default.
• W3136985572 hasConcept C126322002 @default.
• W3136985572 hasConcept C12823836 @default.
• W3136985572 hasConcept C13373296 @default.
• W3136985572 hasConcept C203014093 @default.
• W3136985572 hasConcept C25532541 @default.
• W3136985572 hasConcept C2775866117 @default.
• W3136985572 hasConcept C2776090121 @default.
• W3136985572 hasConcept C2780942790 @default.
• W3136985572 hasConcept C2993327898 @default.
• W3136985572 hasConcept C3020391436 @default.
• W3136985572 hasConcept C553184892 @default.
• W3136985572 hasConcept C71924100 @default.
• W3136985572 hasConcept C8891405 @default.
• W3136985572 hasConcept C89560881 @default.
• W3136985572 hasConceptScore W3136985572C126322002 @default.

• next