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• W3136990145 endingPage "166131" @default.
• W3136990145 startingPage "166131" @default.
• W3136990145 abstract "Pregnant women often have to take medication either for pregnancy-related diseases or for previously existing medical conditions. Current maternal medications pose fetal risks due to off target accumulation in the fetus. Nanoparticles, engineered particles in the nanometer scale, have been used for targeted drug delivery to the site of action without off-target effects. This has opened new avenues for treatment of pregnancy-associated diseases while minimizing risks on the fetus. It is therefore instrumental to study the potential transfer of nanoparticles from the mother to the fetus. Due to limitations of in vivo and ex vivo models, an in vitro model mimicking the in vivo situation is essential. Placenta-on-a-chip provides a microphysiological recapitulation of the human placenta. Here, we reviewed the fetal risks associated with current therapeutic approaches during pregnancy, analyzed the advantages and limitations of current models used for nanoparticle assessment, and highlighted the current need for using dynamic placenta-on-a-chip models for assessing the safety of novel nanoparticle-based therapies during pregnancy. • We provided an overview of clinical challenges during pregnancy. • We introduced nanoparticles as a promising tool to overcome these challenges. • We discussed available models for fetal risk assessment with their pros and cons. • We summarized and compared the studies on nanoparticles using different models. • The dynamic placenta-on-a-chip model is an efficient surrogate for animal models." @default.
• W3136990145 created "2021-03-29" @default.
• W3136990145 creator A5000267814 @default.
• W3136990145 creator A5013120731 @default.
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• W3136990145 creator A5055330752 @default.
• W3136990145 creator A5065749563 @default.
• W3136990145 creator A5069895390 @default.
• W3136990145 creator A5087996421 @default.
• W3136990145 date "2021-07-01" @default.
• W3136990145 modified "2023-09-29" @default.
• W3136990145 title "Dynamic placenta-on-a-chip model for fetal risk assessment of nanoparticles intended to treat pregnancy-associated diseases" @default.
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