Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136993545> ?p ?o ?g. }
- W3136993545 abstract "Obesity is common in the middle aged population and it increases the risks of diabetes, cardiovascular diseases, certain cancers, and dementia. Yet, its etiology remains incompletely understood. Here, we show that ectopic expression of HB-EGF, an important regulator of neurogenesis, in Nestin+ neuroepithelial progenitors with the Cre-LoxP system leads to development of spontaneous middle age obesity in male mice accompanied by hyperglycemia and insulin resistance. The Nestin-HB-EGF mice show decreases in food uptake, energy expenditure, and physical activity, suggesting that reduced energy expenditure underlies the pathogenesis of this obesity model. However, HB-EGF expression in appetite-controlling POMC or AgRP neurons or adipocytes fails to induce obesity. Mechanistically, HB-EGF suppresses expression of Hypocretin/Orexin, an orexigenic neuropeptide hormone, in the hypothalamus of middle aged Nestin-HB-EGF mice. Hypothalamus Orexin administration alleviates the obese and hyperglycemic phenotypes in Nestin-HB-EGF mice. This study uncovers an important role for HB-EGF in regulating Orexin expression and energy expenditure and establishes a midlife obesity model whose pathogenesis involves age-dependent changes in hypothalamus neurons." @default.
- W3136993545 created "2021-03-29" @default.
- W3136993545 creator A5006058880 @default.
- W3136993545 creator A5008044292 @default.
- W3136993545 creator A5016124646 @default.
- W3136993545 creator A5017259423 @default.
- W3136993545 creator A5029355578 @default.
- W3136993545 creator A5032062559 @default.
- W3136993545 creator A5034565482 @default.
- W3136993545 creator A5046965274 @default.
- W3136993545 creator A5056839889 @default.
- W3136993545 creator A5057741217 @default.
- W3136993545 creator A5084345521 @default.
- W3136993545 creator A5084919650 @default.
- W3136993545 creator A5086853937 @default.
- W3136993545 creator A5090932841 @default.
- W3136993545 date "2021-03-14" @default.
- W3136993545 modified "2023-10-16" @default.
- W3136993545 title "Elevated HB‐EGF expression in neural stem cells causes middle age obesity by suppressing Hypocretin/Orexin expression" @default.
- W3136993545 cites W1733539716 @default.
- W3136993545 cites W1820089171 @default.
- W3136993545 cites W1963690717 @default.
- W3136993545 cites W1977993125 @default.
- W3136993545 cites W1982835803 @default.
- W3136993545 cites W1983445020 @default.
- W3136993545 cites W1989104104 @default.
- W3136993545 cites W1991888662 @default.
- W3136993545 cites W1992895646 @default.
- W3136993545 cites W1994143270 @default.
- W3136993545 cites W1999877624 @default.
- W3136993545 cites W2002941555 @default.
- W3136993545 cites W2005346993 @default.
- W3136993545 cites W2011961689 @default.
- W3136993545 cites W2019174868 @default.
- W3136993545 cites W2026363549 @default.
- W3136993545 cites W2037840128 @default.
- W3136993545 cites W2038086562 @default.
- W3136993545 cites W2039073469 @default.
- W3136993545 cites W2040848846 @default.
- W3136993545 cites W2043875236 @default.
- W3136993545 cites W2058070208 @default.
- W3136993545 cites W2062581650 @default.
- W3136993545 cites W2064521325 @default.
- W3136993545 cites W2067572657 @default.
- W3136993545 cites W206871353 @default.
- W3136993545 cites W2072154498 @default.
- W3136993545 cites W2074436236 @default.
- W3136993545 cites W2079483678 @default.
- W3136993545 cites W2091535724 @default.
- W3136993545 cites W2107396244 @default.
- W3136993545 cites W2116739745 @default.
- W3136993545 cites W2138419089 @default.
- W3136993545 cites W2142401354 @default.
- W3136993545 cites W2150861078 @default.
- W3136993545 cites W2151172917 @default.
- W3136993545 cites W2154696002 @default.
- W3136993545 cites W2159953069 @default.
- W3136993545 cites W2163470859 @default.
- W3136993545 cites W2184717764 @default.
- W3136993545 cites W2186657320 @default.
- W3136993545 cites W2341954532 @default.
- W3136993545 cites W2345328813 @default.
- W3136993545 cites W2462607016 @default.
- W3136993545 cites W2485551923 @default.
- W3136993545 cites W2510411424 @default.
- W3136993545 cites W2750420823 @default.
- W3136993545 cites W2754385607 @default.
- W3136993545 cites W2792443129 @default.
- W3136993545 cites W2891386987 @default.
- W3136993545 cites W2895292592 @default.
- W3136993545 cites W2903688295 @default.
- W3136993545 cites W2909144619 @default.
- W3136993545 cites W2917520831 @default.
- W3136993545 cites W2941260787 @default.
- W3136993545 cites W2971615603 @default.
- W3136993545 cites W3004538133 @default.
- W3136993545 cites W3040810341 @default.
- W3136993545 cites W4360894064 @default.
- W3136993545 doi "https://doi.org/10.1096/fj.202001945r" @default.
- W3136993545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33715219" @default.
- W3136993545 hasPublicationYear "2021" @default.
- W3136993545 type Work @default.
- W3136993545 sameAs 3136993545 @default.
- W3136993545 citedByCount "2" @default.
- W3136993545 countsByYear W31369935452023 @default.
- W3136993545 crossrefType "journal-article" @default.
- W3136993545 hasAuthorship W3136993545A5006058880 @default.
- W3136993545 hasAuthorship W3136993545A5008044292 @default.
- W3136993545 hasAuthorship W3136993545A5016124646 @default.
- W3136993545 hasAuthorship W3136993545A5017259423 @default.
- W3136993545 hasAuthorship W3136993545A5029355578 @default.
- W3136993545 hasAuthorship W3136993545A5032062559 @default.
- W3136993545 hasAuthorship W3136993545A5034565482 @default.
- W3136993545 hasAuthorship W3136993545A5046965274 @default.
- W3136993545 hasAuthorship W3136993545A5056839889 @default.
- W3136993545 hasAuthorship W3136993545A5057741217 @default.
- W3136993545 hasAuthorship W3136993545A5084345521 @default.
- W3136993545 hasAuthorship W3136993545A5084919650 @default.
- W3136993545 hasAuthorship W3136993545A5086853937 @default.
- W3136993545 hasAuthorship W3136993545A5090932841 @default.