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- W3136993741 abstract "Germline mutations of CHEK2 have been reported in various types of disease including breast cancer, ovarian cancer, colorectal cancer and prostate cancer. We generated two iPSC lines ZNHi001-A and ZNHi001-B from a prostate cancer patient carrying germline mutation in CHEK2 (c.667C＞T, also p.R223C) which may increase the risk of prostate cancer. Pluripotency and multi-lineage differentiation capacity of the two iPSC lines were confirmed by gene expression and teratoma assay. The generated iPSC lines carrying specific CHEK2 mutation might be a useful resource to study the pathogenic mechanism and develop potential therapeutic strategy of prostate cancer." @default.
- W3136993741 created "2021-03-29" @default.
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- W3136993741 date "2021-05-01" @default.
- W3136993741 modified "2023-10-18" @default.
- W3136993741 title "Generation of two induced pluripotent stem cell lines from blood cells of a prostate cancer patient carrying germline mutation in CHEK2" @default.
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- W3136993741 doi "https://doi.org/10.1016/j.scr.2021.102299" @default.
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