Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136994001> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W3136994001 endingPage "S294" @default.
- W3136994001 startingPage "S294" @default.
- W3136994001 abstract "Purpose Vasculitis had been considered a histopathological marker in severe form of both cellular and humoral rejection. However, in mild forms of rejections, it has not been considered a diagnostic and prognostic histopathologic criterion. Aim of this study is to assess clinical relevance of vasculitis, in terms of mortality and cardiac allograft vasculopathy development, in the mild forms of rejection in heart transplanted patients. Methods We reviewed 2794 monitoring endomyocardial biopsies from 170 adult heart transplanted pts at our center. On endomyocardial biopsies, we evaluated the presence of vasculitis in the different types of rejection . Clinical data were collected during follow up. A Multi-State Markov model was applied to describe the rejection dynamic profile and hazard for mortality, persistence of rejection and CAV development.. We used as reference population the registry data of patients who underwent HTX from 2004 to 2018 provided by the International Society for Heart and Lung Transplantation (ISHLT) Thoracic Organ Transplant Registry Results Vasculitis was detected in 442 endomyocardial biopsies ( 442/2794, 15,8%) with an incremental percent distribution according to the severity of rejection. In ACR, vasculitis significantly increased the risk of mortality by 9% (HR [95% CI]: 1.09; [1.00-1.18]) the hazard of mortality if the patient was negative for ACR and by 14% (HR [95% CI]: 1.14; [1.02-1.37], if the patients was negative for ACR, and by 14% in a mild form of rejection (1R). Similar results were obtained for pAMR and mixed rejection. In ACR, pAMR and mixed rejection patients with vasculitis have a shorter life expectancy than patients without with a loss of four months at ten year follow up for ACR, and of 9 months for pAMR and mixed rejection. Conclusion Vasculitis when present, independently from the grade and type of rejection, carries a negative prognostic value. The worse histopathological feature was represented by the association of pAMR+ACR and vasculitis." @default.
- W3136994001 created "2021-03-29" @default.
- W3136994001 creator A5001872562 @default.
- W3136994001 creator A5006510708 @default.
- W3136994001 creator A5010592800 @default.
- W3136994001 creator A5013041243 @default.
- W3136994001 creator A5018227996 @default.
- W3136994001 creator A5019373056 @default.
- W3136994001 creator A5022182548 @default.
- W3136994001 creator A5027544303 @default.
- W3136994001 creator A5052875930 @default.
- W3136994001 creator A5059253699 @default.
- W3136994001 creator A5062435112 @default.
- W3136994001 creator A5065339834 @default.
- W3136994001 creator A5071922696 @default.
- W3136994001 creator A5074231282 @default.
- W3136994001 creator A5077167101 @default.
- W3136994001 creator A5082435351 @default.
- W3136994001 creator A5082533033 @default.
- W3136994001 creator A5086285478 @default.
- W3136994001 creator A5091162926 @default.
- W3136994001 date "2021-04-01" @default.
- W3136994001 modified "2023-09-27" @default.
- W3136994001 title "Vasculitis on Heart Transplant as an Emerging Prognostic Factor" @default.
- W3136994001 doi "https://doi.org/10.1016/j.healun.2021.01.834" @default.
- W3136994001 hasPublicationYear "2021" @default.
- W3136994001 type Work @default.
- W3136994001 sameAs 3136994001 @default.
- W3136994001 citedByCount "0" @default.
- W3136994001 crossrefType "journal-article" @default.
- W3136994001 hasAuthorship W3136994001A5001872562 @default.
- W3136994001 hasAuthorship W3136994001A5006510708 @default.
- W3136994001 hasAuthorship W3136994001A5010592800 @default.
- W3136994001 hasAuthorship W3136994001A5013041243 @default.
- W3136994001 hasAuthorship W3136994001A5018227996 @default.
- W3136994001 hasAuthorship W3136994001A5019373056 @default.
- W3136994001 hasAuthorship W3136994001A5022182548 @default.
- W3136994001 hasAuthorship W3136994001A5027544303 @default.
- W3136994001 hasAuthorship W3136994001A5052875930 @default.
- W3136994001 hasAuthorship W3136994001A5059253699 @default.
- W3136994001 hasAuthorship W3136994001A5062435112 @default.
- W3136994001 hasAuthorship W3136994001A5065339834 @default.
- W3136994001 hasAuthorship W3136994001A5071922696 @default.
- W3136994001 hasAuthorship W3136994001A5074231282 @default.
- W3136994001 hasAuthorship W3136994001A5077167101 @default.
- W3136994001 hasAuthorship W3136994001A5082435351 @default.
- W3136994001 hasAuthorship W3136994001A5082533033 @default.
- W3136994001 hasAuthorship W3136994001A5086285478 @default.
- W3136994001 hasAuthorship W3136994001A5091162926 @default.
- W3136994001 hasBestOaLocation W31369940011 @default.
- W3136994001 hasConcept C126322002 @default.
- W3136994001 hasConcept C16005928 @default.
- W3136994001 hasConcept C164705383 @default.
- W3136994001 hasConcept C177713679 @default.
- W3136994001 hasConcept C2776015282 @default.
- W3136994001 hasConcept C2778198053 @default.
- W3136994001 hasConcept C2778849806 @default.
- W3136994001 hasConcept C2779134260 @default.
- W3136994001 hasConcept C71924100 @default.
- W3136994001 hasConceptScore W3136994001C126322002 @default.
- W3136994001 hasConceptScore W3136994001C16005928 @default.
- W3136994001 hasConceptScore W3136994001C164705383 @default.
- W3136994001 hasConceptScore W3136994001C177713679 @default.
- W3136994001 hasConceptScore W3136994001C2776015282 @default.
- W3136994001 hasConceptScore W3136994001C2778198053 @default.
- W3136994001 hasConceptScore W3136994001C2778849806 @default.
- W3136994001 hasConceptScore W3136994001C2779134260 @default.
- W3136994001 hasConceptScore W3136994001C71924100 @default.
- W3136994001 hasIssue "4" @default.
- W3136994001 hasLocation W31369940011 @default.
- W3136994001 hasOpenAccess W3136994001 @default.
- W3136994001 hasPrimaryLocation W31369940011 @default.
- W3136994001 hasRelatedWork W2011347913 @default.
- W3136994001 hasRelatedWork W2049397185 @default.
- W3136994001 hasRelatedWork W2073151595 @default.
- W3136994001 hasRelatedWork W2074833529 @default.
- W3136994001 hasRelatedWork W2159512267 @default.
- W3136994001 hasRelatedWork W2304633692 @default.
- W3136994001 hasRelatedWork W2399063111 @default.
- W3136994001 hasRelatedWork W2738981461 @default.
- W3136994001 hasRelatedWork W4234833016 @default.
- W3136994001 hasRelatedWork W4297184974 @default.
- W3136994001 hasVolume "40" @default.
- W3136994001 isParatext "false" @default.
- W3136994001 isRetracted "false" @default.
- W3136994001 magId "3136994001" @default.
- W3136994001 workType "article" @default.