FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136995308> ?p ?o ?g. }

• W3136995308 endingPage "e0248985" @default.
• W3136995308 startingPage "e0248985" @default.
• W3136995308 abstract "There are limited treatments for dyschromia in burn hypertrophic scars (HTSs). Initial work in Duroc pig models showed that regions of scar that are light or dark have equal numbers of melanocytes. This study aims to confirm melanocyte presence in regions of hypo- and hyper-pigmentation in an animal model and patient samples. In a Duroc pig model, melanocyte presence was confirmed using en face staining. Patients with dyschromic HTSs had demographic, injury details, and melanin indices collected. Punch biopsies were taken of regions of hyper-, hypo-, or normally pigmented scar and skin. Biopsies were processed to obtain epidermal sheets (ESs). A subset of ESs were en face stained with melanocyte marker, S100β. Melanocytes were isolated from a different subset. Melanocytes were treated with NDP α-MSH, a pigmentation stimulator. mRNA was isolated from cells, and was used to evaluate gene expression of melanin-synthetic genes. In patient and pig scars, regions of hyper-, hypo-, and normal pigmentation had significantly different melanin indices. S100β en face staining showed that regions of hyper- and hypo-pigmentation contained the same number of melanocytes, but these cells had different dendricity/activity. Treatment of hypo-pigmented melanocytes with NDP α-MSH produced melanin by microscopy. Melanin-synthetic genes were upregulated in treated cells over controls. While traditionally it may be thought that hypopigmented regions of burn HTS display this phenotype because of the absence of pigment-producing cells, these data show that inactive melanocytes are present in these scar regions. By treating with a pigment stimulator, cells can be induced to re-pigment." @default.
• W3136995308 created "2021-03-29" @default.
• W3136995308 creator A5030596322 @default.
• W3136995308 creator A5041249947 @default.
• W3136995308 creator A5049502808 @default.
• W3136995308 creator A5054815816 @default.
• W3136995308 creator A5063369009 @default.
• W3136995308 creator A5071958879 @default.
• W3136995308 creator A5074654270 @default.
• W3136995308 creator A5090108320 @default.
• W3136995308 date "2021-03-25" @default.
• W3136995308 modified "2023-10-16" @default.
• W3136995308 title "Hypopigmented burn hypertrophic scar contains melanocytes that can be signaled to re-pigment by synthetic alpha-melanocyte stimulating hormone in vitro" @default.
• W3136995308 cites W1584274125 @default.
• W3136995308 cites W1985453593 @default.
• W3136995308 cites W1987814680 @default.
• W3136995308 cites W2013102804 @default.
• W3136995308 cites W2016791486 @default.
• W3136995308 cites W2026651067 @default.
• W3136995308 cites W2046442497 @default.
• W3136995308 cites W2057155063 @default.
• W3136995308 cites W2078820161 @default.
• W3136995308 cites W2158117735 @default.
• W3136995308 cites W2161888715 @default.
• W3136995308 cites W2237570137 @default.
• W3136995308 cites W2312620443 @default.
• W3136995308 cites W2313548850 @default.
• W3136995308 cites W2890924148 @default.
• W3136995308 cites W2920917666 @default.
• W3136995308 cites W2983317875 @default.
• W3136995308 cites W3006448256 @default.
• W3136995308 cites W3092671357 @default.
• W3136995308 cites W4236866389 @default.
• W3136995308 doi "https://doi.org/10.1371/journal.pone.0248985" @default.
• W3136995308 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7993611" @default.
• W3136995308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33765043" @default.
• W3136995308 hasPublicationYear "2021" @default.
• W3136995308 type Work @default.
• W3136995308 sameAs 3136995308 @default.
• W3136995308 citedByCount "10" @default.
• W3136995308 countsByYear W31369953082021 @default.
• W3136995308 countsByYear W31369953082022 @default.
• W3136995308 countsByYear W31369953082023 @default.
• W3136995308 crossrefType "journal-article" @default.
• W3136995308 hasAuthorship W3136995308A5030596322 @default.
• W3136995308 hasAuthorship W3136995308A5041249947 @default.
• W3136995308 hasAuthorship W3136995308A5049502808 @default.
• W3136995308 hasAuthorship W3136995308A5054815816 @default.
• W3136995308 hasAuthorship W3136995308A5063369009 @default.
• W3136995308 hasAuthorship W3136995308A5071958879 @default.
• W3136995308 hasAuthorship W3136995308A5074654270 @default.
• W3136995308 hasAuthorship W3136995308A5090108320 @default.
• W3136995308 hasBestOaLocation W31369953081 @default.
• W3136995308 hasConcept C104317684 @default.
• W3136995308 hasConcept C107538193 @default.
• W3136995308 hasConcept C127716648 @default.
• W3136995308 hasConcept C142724271 @default.
• W3136995308 hasConcept C181199279 @default.
• W3136995308 hasConcept C2777642821 @default.
• W3136995308 hasConcept C2777658100 @default.
• W3136995308 hasConcept C2779769559 @default.
• W3136995308 hasConcept C502942594 @default.
• W3136995308 hasConcept C54355233 @default.
• W3136995308 hasConcept C55493867 @default.
• W3136995308 hasConcept C71924100 @default.
• W3136995308 hasConcept C74864618 @default.
• W3136995308 hasConcept C86803240 @default.
• W3136995308 hasConcept C87554066 @default.
• W3136995308 hasConcept C94435474 @default.
• W3136995308 hasConceptScore W3136995308C104317684 @default.
• W3136995308 hasConceptScore W3136995308C107538193 @default.
• W3136995308 hasConceptScore W3136995308C127716648 @default.
• W3136995308 hasConceptScore W3136995308C142724271 @default.
• W3136995308 hasConceptScore W3136995308C181199279 @default.
• W3136995308 hasConceptScore W3136995308C2777642821 @default.
• W3136995308 hasConceptScore W3136995308C2777658100 @default.
• W3136995308 hasConceptScore W3136995308C2779769559 @default.
• W3136995308 hasConceptScore W3136995308C502942594 @default.
• W3136995308 hasConceptScore W3136995308C54355233 @default.
• W3136995308 hasConceptScore W3136995308C55493867 @default.
• W3136995308 hasConceptScore W3136995308C71924100 @default.
• W3136995308 hasConceptScore W3136995308C74864618 @default.
• W3136995308 hasConceptScore W3136995308C86803240 @default.
• W3136995308 hasConceptScore W3136995308C87554066 @default.
• W3136995308 hasConceptScore W3136995308C94435474 @default.
• W3136995308 hasIssue "3" @default.
• W3136995308 hasLocation W31369953081 @default.
• W3136995308 hasLocation W31369953082 @default.
• W3136995308 hasLocation W31369953083 @default.
• W3136995308 hasOpenAccess W3136995308 @default.
• W3136995308 hasPrimaryLocation W31369953081 @default.
• W3136995308 hasRelatedWork W1923508075 @default.
• W3136995308 hasRelatedWork W200466334 @default.
• W3136995308 hasRelatedWork W2005947606 @default.
• W3136995308 hasRelatedWork W2036926779 @default.
• W3136995308 hasRelatedWork W2093862782 @default.
• W3136995308 hasRelatedWork W3080678070 @default.
• W3136995308 hasRelatedWork W3136995308 @default.

• next