FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137003442> ?p ?o ?g. }

• W3137003442 endingPage "2977" @default.
• W3137003442 startingPage "2964" @default.
• W3137003442 abstract "Calcineurin inhibitors (CNIs) are potent immunosuppressive agents, universally used following solid organ transplantation to prevent rejection. Although effective, the long-term use of CNIs is associated with nephrotoxicity. The etiology of this adverse effect is complex, and effective therapeutic interventions remain to be determined. Using a combination of in vitro techniques and a mouse model of CNI-mediated nephrotoxicity, we found that the CNIs, cyclosporine A (CsA), and tacrolimus (TAC) share a similar mechanism of tubular epithelial kidney cell injury, including mitochondrial dysfunction and release of High-Mobility Group Box I (HMGB1). CNIs promote bioenergetic reprogramming due to mitochondrial dysfunction and a shift toward glycolytic metabolism. These events were accompanied by diminished cell-to-cell adhesion, loss of the epithelial cell phenotype, and release of HMGB1. Notably, Erk1/2 inhibitors effectively diminished HMGB1 release, and similar inhibitor was observed on inclusion of pan-caspase inhibitor zVAD-FMK. In vivo, while CNIs activate tissue proremodeling signaling pathways, MAPK/Erk1/2 inhibitor prevented nephrotoxicity, including diminished HMGB1 release from kidney epithelial cells and accumulation in urine. In summary, HMGB1 is an early indicator and marker of progressive nephrotoxicity induced by CNIs. We suggest that proremodeling signaling pathway and loss of mitochondrial redox/bioenergetics homeostasis are crucial therapeutic targets to ameliorate CNI-mediated nephrotoxicity." @default.
• W3137003442 created "2021-03-29" @default.
• W3137003442 creator A5038933635 @default.
• W3137003442 creator A5040651810 @default.
• W3137003442 creator A5040812011 @default.
• W3137003442 creator A5058370509 @default.
• W3137003442 creator A5061551777 @default.
• W3137003442 creator A5062506120 @default.
• W3137003442 date "2021-09-01" @default.
• W3137003442 modified "2023-10-12" @default.
• W3137003442 title "Bioenergetic maladaptation and release of HMGB1 in calcineurin inhibitor-mediated nephrotoxicity" @default.
• W3137003442 cites W1468684773 @default.
• W3137003442 cites W1490007860 @default.
• W3137003442 cites W1493525820 @default.
• W3137003442 cites W1520683642 @default.
• W3137003442 cites W1533852107 @default.
• W3137003442 cites W1728006398 @default.
• W3137003442 cites W1978205735 @default.
• W3137003442 cites W1982153813 @default.
• W3137003442 cites W1987844678 @default.
• W3137003442 cites W1991016726 @default.
• W3137003442 cites W1994190235 @default.
• W3137003442 cites W2002200543 @default.
• W3137003442 cites W2002201401 @default.
• W3137003442 cites W2003655983 @default.
• W3137003442 cites W2004266769 @default.
• W3137003442 cites W2008441997 @default.
• W3137003442 cites W2016345983 @default.
• W3137003442 cites W2018653121 @default.
• W3137003442 cites W2024447823 @default.
• W3137003442 cites W2035464681 @default.
• W3137003442 cites W2036074904 @default.
• W3137003442 cites W2045316920 @default.
• W3137003442 cites W2050805027 @default.
• W3137003442 cites W2050979875 @default.
• W3137003442 cites W2066992691 @default.
• W3137003442 cites W2074518940 @default.
• W3137003442 cites W2074937649 @default.
• W3137003442 cites W2076603448 @default.
• W3137003442 cites W2092984629 @default.
• W3137003442 cites W2097742467 @default.
• W3137003442 cites W2122039897 @default.
• W3137003442 cites W2124999845 @default.
• W3137003442 cites W2125751904 @default.
• W3137003442 cites W2134316956 @default.
• W3137003442 cites W2136160240 @default.
• W3137003442 cites W2136728678 @default.
• W3137003442 cites W2160369507 @default.
• W3137003442 cites W2162229546 @default.
• W3137003442 cites W2164714222 @default.
• W3137003442 cites W2264921308 @default.
• W3137003442 cites W2299019178 @default.
• W3137003442 cites W2321489821 @default.
• W3137003442 cites W2433496571 @default.
• W3137003442 cites W2436471876 @default.
• W3137003442 cites W2471692177 @default.
• W3137003442 cites W2531236783 @default.
• W3137003442 cites W2611851326 @default.
• W3137003442 cites W2620092475 @default.
• W3137003442 cites W2621172390 @default.
• W3137003442 cites W2743743758 @default.
• W3137003442 cites W2750514629 @default.
• W3137003442 cites W2810427028 @default.
• W3137003442 cites W2896095120 @default.
• W3137003442 cites W2920064913 @default.
• W3137003442 cites W3045773277 @default.
• W3137003442 doi "https://doi.org/10.1111/ajt.16561" @default.
• W3137003442 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8429074" @default.
• W3137003442 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33724664" @default.
• W3137003442 hasPublicationYear "2021" @default.
• W3137003442 type Work @default.
• W3137003442 sameAs 3137003442 @default.
• W3137003442 citedByCount "7" @default.
• W3137003442 countsByYear W31370034422021 @default.
• W3137003442 countsByYear W31370034422022 @default.
• W3137003442 countsByYear W31370034422023 @default.
• W3137003442 crossrefType "journal-article" @default.
• W3137003442 hasAuthorship W3137003442A5038933635 @default.
• W3137003442 hasAuthorship W3137003442A5040651810 @default.
• W3137003442 hasAuthorship W3137003442A5040812011 @default.
• W3137003442 hasAuthorship W3137003442A5058370509 @default.
• W3137003442 hasAuthorship W3137003442A5061551777 @default.
• W3137003442 hasAuthorship W3137003442A5062506120 @default.
• W3137003442 hasBestOaLocation W31370034422 @default.
• W3137003442 hasConcept C126189478 @default.
• W3137003442 hasConcept C126322002 @default.
• W3137003442 hasConcept C128057223 @default.
• W3137003442 hasConcept C134018914 @default.
• W3137003442 hasConcept C170493617 @default.
• W3137003442 hasConcept C2780091579 @default.
• W3137003442 hasConcept C2780545709 @default.
• W3137003442 hasConcept C2911091166 @default.
• W3137003442 hasConcept C71924100 @default.
• W3137003442 hasConcept C98274493 @default.
• W3137003442 hasConceptScore W3137003442C126189478 @default.
• W3137003442 hasConceptScore W3137003442C126322002 @default.
• W3137003442 hasConceptScore W3137003442C128057223 @default.
• W3137003442 hasConceptScore W3137003442C134018914 @default.

• next