Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137005940> ?p ?o ?g. }
- W3137005940 abstract "Astrocytes elicit transient Ca2+ elevations induced by G protein-coupled receptors (GPCRs), yet their role in vivo remains unknown. To address this, transgenic mice with astrocytic expression of the optogenetic Gq-type GPCR, Optoα1AR, were established, in which transient Ca2+ elevations similar to those in wild type mice were induced by brief blue light illumination. Activation of cortical astrocytes resulted in an adenosine A1 receptor-dependent inhibition of neuronal activity. Moreover, sensory stimulation with astrocytic activation induced long-term depression of sensory evoked response. At the behavioral level, repeated astrocytic activation in the anterior cortex gradually affected novel open field exploratory behavior, and remote memory was enhanced in a novel object recognition task. These effects were blocked by A1 receptor antagonism. Together, we demonstrate that GPCR-triggered Ca2+ elevation in cortical astrocytes has causal impacts on neuronal activity and behavior." @default.
- W3137005940 created "2021-03-29" @default.
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- W3137005940 date "2021-03-22" @default.
- W3137005940 modified "2023-10-18" @default.
- W3137005940 title "Transient Astrocytic Gq Signaling Underlies Remote Memory Enhancement" @default.
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