Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137017528> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W3137017528 endingPage "927" @default.
- W3137017528 startingPage "921" @default.
- W3137017528 abstract "Physical impairment after critical illness is recognized as a part of the post-intensive care syndrome (PICS). About one third of intensive care unit (ICU) survivors suffer from long-term physical disability, yet the underlying pathophysiological mechanisms remain poorly understood. The pro-inflammatory alarmin, high mobility group box 1 (HMGB1), promotes muscle dysfunction in experimental models, and HMGB1 stays elevated in some patients after ICU discharge. Accordingly, we investigated the relationship between HMGB1 plasma levels and physical performance in ICU survivors.Prospective cohort study of 100 ICU survivors from the general ICU at the Karolinska University Hospital, Sweden. Patients returned for follow up at 3 (58 patients) and 6 months (51 patients) after ICU discharge. Blood samples were collected, and a 6-minute walk test (6-MWT), a handgrip-strength test (HST), and a timed-stands test (TST) were performed.Compared to reference values of the different physical tests, 16% of patients underperformed at all tests at 3 months and 12% at 6 months. All test results, except hand-grip strength left, improved significantly over the follow-up period (P < .05). There was no significant association between plasma HMGB1 levels at 3 and 6 months and scores on the three tests (6-MWT, TST, and HST) (P = .50-0.69).In this follow-up study of ICU survivors, we found no significant association between plasma HMGB1 levels and physical performance. Additional follow-up studies of HMGB1 plasma levels and muscle function in ICU survivors are still warranted.HMGB-1, a marker of cell damage and activation, is known to increase in ICU patients. In study participants at 3- to 6-month post-ICU stay, HMGB-1 levels were still elevated, although no association to the primary outcome, physical performance, was found. Mechanisms for failure to recover physical performance post-ICU remain unclear, and investigations into cause of post-intensive care syndrome need to continue.ClinicalTrials.gov identifier NCT02914756." @default.
- W3137017528 created "2021-03-29" @default.
- W3137017528 creator A5009470021 @default.
- W3137017528 creator A5011924649 @default.
- W3137017528 creator A5014663996 @default.
- W3137017528 creator A5033009220 @default.
- W3137017528 creator A5053086172 @default.
- W3137017528 creator A5054621014 @default.
- W3137017528 creator A5064463841 @default.
- W3137017528 creator A5086316375 @default.
- W3137017528 date "2021-03-27" @default.
- W3137017528 modified "2023-10-01" @default.
- W3137017528 title "Plasma HMGB1 levels and physical performance in ICU survivors" @default.
- W3137017528 cites W2010439133 @default.
- W3137017528 cites W2015329932 @default.
- W3137017528 cites W2022389138 @default.
- W3137017528 cites W2034466878 @default.
- W3137017528 cites W2038355611 @default.
- W3137017528 cites W2040361205 @default.
- W3137017528 cites W2042705095 @default.
- W3137017528 cites W2053940416 @default.
- W3137017528 cites W2073489092 @default.
- W3137017528 cites W2087694898 @default.
- W3137017528 cites W2102110418 @default.
- W3137017528 cites W2111597613 @default.
- W3137017528 cites W2111861407 @default.
- W3137017528 cites W2111897545 @default.
- W3137017528 cites W2115206790 @default.
- W3137017528 cites W2116201938 @default.
- W3137017528 cites W2118240638 @default.
- W3137017528 cites W2132267762 @default.
- W3137017528 cites W2140044661 @default.
- W3137017528 cites W2158881221 @default.
- W3137017528 cites W2164714222 @default.
- W3137017528 cites W2165845721 @default.
- W3137017528 cites W2170128875 @default.
- W3137017528 cites W2227283568 @default.
- W3137017528 cites W2233131938 @default.
- W3137017528 cites W2441092170 @default.
- W3137017528 cites W2792452770 @default.
- W3137017528 cites W2793077245 @default.
- W3137017528 cites W2809341712 @default.
- W3137017528 cites W2897276059 @default.
- W3137017528 cites W2952137349 @default.
- W3137017528 cites W2961741174 @default.
- W3137017528 cites W3008750648 @default.
- W3137017528 cites W4245666729 @default.
- W3137017528 doi "https://doi.org/10.1111/aas.13815" @default.
- W3137017528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33725363" @default.
- W3137017528 hasPublicationYear "2021" @default.
- W3137017528 type Work @default.
- W3137017528 sameAs 3137017528 @default.
- W3137017528 citedByCount "0" @default.
- W3137017528 crossrefType "journal-article" @default.
- W3137017528 hasAuthorship W3137017528A5009470021 @default.
- W3137017528 hasAuthorship W3137017528A5011924649 @default.
- W3137017528 hasAuthorship W3137017528A5014663996 @default.
- W3137017528 hasAuthorship W3137017528A5033009220 @default.
- W3137017528 hasAuthorship W3137017528A5053086172 @default.
- W3137017528 hasAuthorship W3137017528A5054621014 @default.
- W3137017528 hasAuthorship W3137017528A5064463841 @default.
- W3137017528 hasAuthorship W3137017528A5086316375 @default.
- W3137017528 hasConcept C126322002 @default.
- W3137017528 hasConcept C1862650 @default.
- W3137017528 hasConcept C188816634 @default.
- W3137017528 hasConcept C2776376669 @default.
- W3137017528 hasConcept C2777433710 @default.
- W3137017528 hasConcept C71924100 @default.
- W3137017528 hasConceptScore W3137017528C126322002 @default.
- W3137017528 hasConceptScore W3137017528C1862650 @default.
- W3137017528 hasConceptScore W3137017528C188816634 @default.
- W3137017528 hasConceptScore W3137017528C2776376669 @default.
- W3137017528 hasConceptScore W3137017528C2777433710 @default.
- W3137017528 hasConceptScore W3137017528C71924100 @default.
- W3137017528 hasFunder F4320322327 @default.
- W3137017528 hasFunder F4320322570 @default.
- W3137017528 hasFunder F4320322581 @default.
- W3137017528 hasFunder F4320324618 @default.
- W3137017528 hasIssue "7" @default.
- W3137017528 hasLocation W31370175281 @default.
- W3137017528 hasLocation W31370175282 @default.
- W3137017528 hasOpenAccess W3137017528 @default.
- W3137017528 hasPrimaryLocation W31370175281 @default.
- W3137017528 hasRelatedWork W2055141553 @default.
- W3137017528 hasRelatedWork W2076993109 @default.
- W3137017528 hasRelatedWork W2159723344 @default.
- W3137017528 hasRelatedWork W2295722933 @default.
- W3137017528 hasRelatedWork W2407093027 @default.
- W3137017528 hasRelatedWork W2411569915 @default.
- W3137017528 hasRelatedWork W2515762743 @default.
- W3137017528 hasRelatedWork W2531350361 @default.
- W3137017528 hasRelatedWork W2561481703 @default.
- W3137017528 hasRelatedWork W4283764297 @default.
- W3137017528 hasVolume "65" @default.
- W3137017528 isParatext "false" @default.
- W3137017528 isRetracted "false" @default.
- W3137017528 magId "3137017528" @default.
- W3137017528 workType "article" @default.