Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137029088> ?p ?o ?g. }
- W3137029088 abstract "Broadly neutralizing antibodies (bnAbs) have been developed as potential countermeasures for seasonal and pandemic influenza. Deep characterization of these bnAbs and polyclonal sera provides pivotal understanding for influenza immunity and informs effective vaccine design. However, conventional virus neutralization assays require high-containment laboratories and are difficult to standardize and roboticize. Here, we build a panel of engineered influenza viruses carrying a reporter gene to replace an essential viral gene, and develop an assay using the panel for in-depth profiling of neutralizing antibodies. Replication of these viruses is restricted to cells expressing the missing viral gene, allowing it to be manipulated in a biosafety level 2 environment. We generate the neutralization profile of 24 bnAbs using a 55-virus panel encompassing the near-complete diversity of human H1N1 and H3N2, as well as pandemic subtype viruses. Our system offers in-depth profiling of influenza immunity, including the antibodies against the hemagglutinin stem, a major target of universal influenza vaccines." @default.
- W3137029088 created "2021-03-29" @default.
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- W3137029088 date "2021-03-19" @default.
- W3137029088 modified "2023-10-06" @default.
- W3137029088 title "A comprehensive influenza reporter virus panel for high-throughput deep profiling of neutralizing antibodies" @default.
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- W3137029088 doi "https://doi.org/10.1038/s41467-021-21954-2" @default.
- W3137029088 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7979723" @default.
- W3137029088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33741916" @default.
- W3137029088 hasPublicationYear "2021" @default.