FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137044255> ?p ?o ?g. }

• W3137044255 abstract "The prostate is a hormone-responsive organ where testicular androgens drive the proliferation and survival of prostatic cells, ensuring the development and functioning of this gland throughout life. Androgen deprivation therapy leads to apoptosis of prostatic cells and organ regression, and is a cornerstone of prostate cancer and benign prostatic hypertrophy treatment. For several decades, androgen deprivation has been used as an adjuvant to external beam radiotherapy, however, emerging data suggests that the low rates of epithelial proliferation in the castrated prostate imparts radio-resistance. As proliferating cells exhibit increased sensitivity to radiation, we hypothesized that short bursts of synchronized epithelial proliferation, which can be achieved by exogeneous testosterone supplementation prior to targeted high-dose radiation, would maximize sustained prostate ablation, while minimizing damage to surrounding tissues. To test this hypothesis, we designed a novel computed-tomography (CT)-guided stereotactic prostate radiation therapy (CT-SPRT) technique to deliver a single high-dose 25 Gy fraction of X-ray radiation. Sustained prostatic cell ablation was assessed post CT-SPRT by measuring prostate weight, epithelial cell number, and relative contributions of luminal and basal epithelial populations in control and testosterone-pretreated glands. CT-SPRT was safely delivered with no observed damage to surrounding rectal and bladder tissues. Importantly, castrated mice that received a pulse of testosterone to induce synchronous cell proliferation prior to CT-SPRT exhibited significant sustained gland ablation compared to control mice. These results provide new insights in stereotactic radiotherapy sensitivity to maximize prostatic cell ablation and improve our understanding of prostate gland regeneration that can potentially lead to improved non-invasive therapies for benign prostatic hypertrophy and prostate cancer." @default.
• W3137044255 created "2021-03-29" @default.
• W3137044255 creator A5012969489 @default.
• W3137044255 creator A5044390727 @default.
• W3137044255 creator A5046708310 @default.
• W3137044255 creator A5052419680 @default.
• W3137044255 creator A5053707581 @default.
• W3137044255 creator A5055510159 @default.
• W3137044255 creator A5081554911 @default.
• W3137044255 creator A5091607591 @default.
• W3137044255 date "2021-03-22" @default.
• W3137044255 modified "2023-10-13" @default.
• W3137044255 title "Using CT-guided stereotactic prostate radiation therapy (CT-SPRT) to assess sustained murine prostate ablation" @default.
• W3137044255 cites W1987470170 @default.
• W3137044255 cites W2005274657 @default.
• W3137044255 cites W2016844403 @default.
• W3137044255 cites W2025727536 @default.
• W3137044255 cites W2029808948 @default.
• W3137044255 cites W2034483257 @default.
• W3137044255 cites W2063789910 @default.
• W3137044255 cites W2064589748 @default.
• W3137044255 cites W2065479209 @default.
• W3137044255 cites W2071003307 @default.
• W3137044255 cites W2104631398 @default.
• W3137044255 cites W2110069491 @default.
• W3137044255 cites W2128702032 @default.
• W3137044255 cites W2154430204 @default.
• W3137044255 cites W2167198420 @default.
• W3137044255 cites W2171451762 @default.
• W3137044255 cites W2255555283 @default.
• W3137044255 cites W2264309677 @default.
• W3137044255 cites W2523396458 @default.
• W3137044255 cites W2587409635 @default.
• W3137044255 cites W2741499688 @default.
• W3137044255 cites W2765161542 @default.
• W3137044255 cites W2807875253 @default.
• W3137044255 cites W2811472135 @default.
• W3137044255 cites W2890650375 @default.
• W3137044255 cites W2914880936 @default.
• W3137044255 cites W2916438002 @default.
• W3137044255 cites W2919810454 @default.
• W3137044255 doi "https://doi.org/10.1038/s41598-021-86067-8" @default.
• W3137044255 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7985301" @default.
• W3137044255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33753857" @default.
• W3137044255 hasPublicationYear "2021" @default.
• W3137044255 type Work @default.
• W3137044255 sameAs 3137044255 @default.
• W3137044255 citedByCount "0" @default.
• W3137044255 crossrefType "journal-article" @default.
• W3137044255 hasAuthorship W3137044255A5012969489 @default.
• W3137044255 hasAuthorship W3137044255A5044390727 @default.
• W3137044255 hasAuthorship W3137044255A5046708310 @default.
• W3137044255 hasAuthorship W3137044255A5052419680 @default.
• W3137044255 hasAuthorship W3137044255A5053707581 @default.
• W3137044255 hasAuthorship W3137044255A5055510159 @default.
• W3137044255 hasAuthorship W3137044255A5081554911 @default.
• W3137044255 hasAuthorship W3137044255A5091607591 @default.
• W3137044255 hasBestOaLocation W31370442551 @default.
• W3137044255 hasConcept C121608353 @default.
• W3137044255 hasConcept C126322002 @default.
• W3137044255 hasConcept C126894567 @default.
• W3137044255 hasConcept C2776235491 @default.
• W3137044255 hasConcept C2777899217 @default.
• W3137044255 hasConcept C2777911890 @default.
• W3137044255 hasConcept C2778902805 @default.
• W3137044255 hasConcept C2779279991 @default.
• W3137044255 hasConcept C2780192828 @default.
• W3137044255 hasConcept C502942594 @default.
• W3137044255 hasConcept C509974204 @default.
• W3137044255 hasConcept C71315377 @default.
• W3137044255 hasConcept C71924100 @default.
• W3137044255 hasConceptScore W3137044255C121608353 @default.
• W3137044255 hasConceptScore W3137044255C126322002 @default.
• W3137044255 hasConceptScore W3137044255C126894567 @default.
• W3137044255 hasConceptScore W3137044255C2776235491 @default.
• W3137044255 hasConceptScore W3137044255C2777899217 @default.
• W3137044255 hasConceptScore W3137044255C2777911890 @default.
• W3137044255 hasConceptScore W3137044255C2778902805 @default.
• W3137044255 hasConceptScore W3137044255C2779279991 @default.
• W3137044255 hasConceptScore W3137044255C2780192828 @default.
• W3137044255 hasConceptScore W3137044255C502942594 @default.
• W3137044255 hasConceptScore W3137044255C509974204 @default.
• W3137044255 hasConceptScore W3137044255C71315377 @default.
• W3137044255 hasConceptScore W3137044255C71924100 @default.
• W3137044255 hasFunder F4320332161 @default.
• W3137044255 hasIssue "1" @default.
• W3137044255 hasLocation W31370442551 @default.
• W3137044255 hasLocation W31370442552 @default.
• W3137044255 hasLocation W31370442553 @default.
• W3137044255 hasOpenAccess W3137044255 @default.
• W3137044255 hasPrimaryLocation W31370442551 @default.
• W3137044255 hasRelatedWork W2012724875 @default.
• W3137044255 hasRelatedWork W2048579129 @default.
• W3137044255 hasRelatedWork W2080612280 @default.
• W3137044255 hasRelatedWork W2127440557 @default.
• W3137044255 hasRelatedWork W2132731564 @default.
• W3137044255 hasRelatedWork W2150609534 @default.
• W3137044255 hasRelatedWork W2444472156 @default.
• W3137044255 hasRelatedWork W2620095243 @default.
• W3137044255 hasRelatedWork W4292397309 @default.

• next