Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137045793> ?p ?o ?g. }
- W3137045793 endingPage "119364" @default.
- W3137045793 startingPage "119364" @default.
- W3137045793 abstract "β-arrestin2 is a ubiquitously expressed scaffold protein localized on the cytoplasm and plasma membrane. It was originally found to bind to GPCRs, uncoupling G proteins and receptors' binding and inhibiting the signal transduction of the GPCRs. Further investigations have revealed that β-arrestin2 not only mediates the desensitization of GPCRs but also serves as a multifunctional scaffold to mediate receptor internalization, kinase activation, and regulation of various signaling pathways, such as TLR4/NF-κB, MAPK, Wnt, TGF-β, and AMPK/mTOR pathways. β-arrestin2 regulates cell invasion, migration, autophagy, angiogenesis, and anti-inflammatory effects by regulating various signaling pathways, which play a vital role in many physiological and pathological processes. This paper reviews the structure and function of β-arrestin2, the regulation of β-arrestin2 based signaling pathways. The role and mechanism of β-arrestin2 signaling have been delineated in sufficient detail. The prospect of regulating the expression and activity of β-arrestin2 in multisystem diseases holds substantial therapeutic promise." @default.
- W3137045793 created "2021-03-29" @default.
- W3137045793 creator A5028448725 @default.
- W3137045793 creator A5036985869 @default.
- W3137045793 creator A5042347958 @default.
- W3137045793 creator A5063023593 @default.
- W3137045793 creator A5085502751 @default.
- W3137045793 date "2021-06-01" @default.
- W3137045793 modified "2023-10-07" @default.
- W3137045793 title "The role and mechanism of β-arrestin2 in signal transduction" @default.
- W3137045793 cites W177640708 @default.
- W3137045793 cites W1872932367 @default.
- W3137045793 cites W1970637701 @default.
- W3137045793 cites W1978521856 @default.
- W3137045793 cites W1982926119 @default.
- W3137045793 cites W1987060427 @default.
- W3137045793 cites W2012571494 @default.
- W3137045793 cites W2012738439 @default.
- W3137045793 cites W2036434451 @default.
- W3137045793 cites W2037276555 @default.
- W3137045793 cites W2067875575 @default.
- W3137045793 cites W2068050893 @default.
- W3137045793 cites W2074802587 @default.
- W3137045793 cites W2076672895 @default.
- W3137045793 cites W2083753474 @default.
- W3137045793 cites W2083896969 @default.
- W3137045793 cites W2108602359 @default.
- W3137045793 cites W2114108194 @default.
- W3137045793 cites W2115957792 @default.
- W3137045793 cites W2118456764 @default.
- W3137045793 cites W2128670872 @default.
- W3137045793 cites W2149854843 @default.
- W3137045793 cites W2167277304 @default.
- W3137045793 cites W2168648974 @default.
- W3137045793 cites W2214849339 @default.
- W3137045793 cites W2294105046 @default.
- W3137045793 cites W2302828574 @default.
- W3137045793 cites W2303462194 @default.
- W3137045793 cites W2331876349 @default.
- W3137045793 cites W2412668871 @default.
- W3137045793 cites W2471095140 @default.
- W3137045793 cites W2510897743 @default.
- W3137045793 cites W2516277153 @default.
- W3137045793 cites W2517361030 @default.
- W3137045793 cites W2521714238 @default.
- W3137045793 cites W2532950653 @default.
- W3137045793 cites W2554642455 @default.
- W3137045793 cites W2560972252 @default.
- W3137045793 cites W2583996845 @default.
- W3137045793 cites W2586430131 @default.
- W3137045793 cites W2593398654 @default.
- W3137045793 cites W2594049006 @default.
- W3137045793 cites W2597685695 @default.
- W3137045793 cites W2601465249 @default.
- W3137045793 cites W2605570494 @default.
- W3137045793 cites W2610657571 @default.
- W3137045793 cites W2734603799 @default.
- W3137045793 cites W2751424100 @default.
- W3137045793 cites W2763752752 @default.
- W3137045793 cites W2765153686 @default.
- W3137045793 cites W2766862738 @default.
- W3137045793 cites W2778262854 @default.
- W3137045793 cites W2782408527 @default.
- W3137045793 cites W2784283904 @default.
- W3137045793 cites W2784672273 @default.
- W3137045793 cites W2792016711 @default.
- W3137045793 cites W2792884690 @default.
- W3137045793 cites W2794222046 @default.
- W3137045793 cites W2799534791 @default.
- W3137045793 cites W2803854598 @default.
- W3137045793 cites W2804137773 @default.
- W3137045793 cites W2806179026 @default.
- W3137045793 cites W2806584747 @default.
- W3137045793 cites W2819762941 @default.
- W3137045793 cites W2886498462 @default.
- W3137045793 cites W2890090520 @default.
- W3137045793 cites W2906319220 @default.
- W3137045793 cites W2906928229 @default.
- W3137045793 cites W2915245505 @default.
- W3137045793 cites W2915881305 @default.
- W3137045793 cites W2929384972 @default.
- W3137045793 cites W2932085140 @default.
- W3137045793 cites W2934332834 @default.
- W3137045793 cites W2943777910 @default.
- W3137045793 cites W2944230448 @default.
- W3137045793 cites W2951250020 @default.
- W3137045793 cites W2965911669 @default.
- W3137045793 cites W2971580231 @default.
- W3137045793 cites W2972517234 @default.
- W3137045793 cites W2972864777 @default.
- W3137045793 cites W2973290426 @default.
- W3137045793 cites W2984464218 @default.
- W3137045793 cites W2985055171 @default.
- W3137045793 cites W2989614779 @default.
- W3137045793 cites W2989686935 @default.
- W3137045793 cites W2990195728 @default.
- W3137045793 cites W2990226183 @default.
- W3137045793 cites W2990581152 @default.