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- W3137050976 abstract "The coronavirus disease 2019 (COVID-19) pandemic spreading at an alarming rate has taken a heavy toll on the public healthcare systems and economies worldwide. An abnormal and overactivated inflammatory response is occasionally elicited by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and this hyperinflammation is associated with worse prognosis of COVID-19. Theoretically, one would expect patients with asthma to be at a greater risk of SARS-CoV-2 infection considering their increased susceptibility to common respiratory virus-associated exacerbations. Surprisingly, current data do not consistently suggest an increased prevalence of asthma among patients with COVID-19. Considering the high global prevalence of asthma, the characteristics of the disease and/or their conventional therapy might play a role in their potential defense against COVID-19. This may be attributed to the T helper type 2 immune response predominantly seen in patients with asthma. Likewise, asthma therapeutics, including corticosteroids and biologics, may in fact benefit the patients with asthma by alleviating the development of hyperinflammation. On the other hand, elevated IL-17 levels are characteristically seen in a subset of asthma patients with severe disease as well as in patients with COVID-19. Targeting the IL-17 pathway as a treatment strategy could plausibly alleviate acute respiratory distress syndrome (ARDS) in patients with COVID-19 and asthma demonstrating a predominant T helper type 17 response. A clinical trial including a drug targeting this pathway may thus, constitute a logical addition to the global pursuit for effective therapeutics against COVID-19. The complex interplay between the asthma endotypes and COVID-19 is not very well understood and will be discussed in this mini-review." @default.
- W3137050976 created "2021-03-29" @default.
- W3137050976 creator A5027127170 @default.
- W3137050976 creator A5036526525 @default.
- W3137050976 creator A5076412766 @default.
- W3137050976 date "2021-05-01" @default.
- W3137050976 modified "2023-10-06" @default.
- W3137050976 title "Implications of preexisting asthma on COVID-19 pathogenesis" @default.
- W3137050976 cites W1596555805 @default.
- W3137050976 cites W1876031798 @default.
- W3137050976 cites W1977050884 @default.
- W3137050976 cites W2016921919 @default.
- W3137050976 cites W2019394772 @default.
- W3137050976 cites W2024758086 @default.
- W3137050976 cites W2040217868 @default.
- W3137050976 cites W2041272141 @default.
- W3137050976 cites W2048395646 @default.
- W3137050976 cites W2070933011 @default.
- W3137050976 cites W2076102880 @default.
- W3137050976 cites W2090051914 @default.
- W3137050976 cites W2102739294 @default.
- W3137050976 cites W2108615089 @default.
- W3137050976 cites W2115252063 @default.
- W3137050976 cites W2117253480 @default.
- W3137050976 cites W2133504637 @default.
- W3137050976 cites W2136561766 @default.
- W3137050976 cites W2158567115 @default.
- W3137050976 cites W2159262373 @default.
- W3137050976 cites W2166997969 @default.
- W3137050976 cites W2318426089 @default.
- W3137050976 cites W2473651906 @default.
- W3137050976 cites W2491990116 @default.
- W3137050976 cites W2610387541 @default.
- W3137050976 cites W2626956924 @default.
- W3137050976 cites W2730218169 @default.
- W3137050976 cites W2751934223 @default.
- W3137050976 cites W2752655957 @default.
- W3137050976 cites W2892016825 @default.
- W3137050976 cites W2905980333 @default.
- W3137050976 cites W2910383224 @default.
- W3137050976 cites W2911463914 @default.
- W3137050976 cites W2972987119 @default.
- W3137050976 cites W2978357527 @default.
- W3137050976 cites W2990436175 @default.
- W3137050976 cites W3001118548 @default.
- W3137050976 cites W3003945000 @default.
- W3137050976 cites W3007109299 @default.
- W3137050976 cites W3007814559 @default.
- W3137050976 cites W3007940623 @default.
- W3137050976 cites W3008028633 @default.
- W3137050976 cites W3008090866 @default.
- W3137050976 cites W3009859788 @default.
- W3137050976 cites W3009912996 @default.
- W3137050976 cites W3010738632 @default.
- W3137050976 cites W3010930696 @default.
- W3137050976 cites W3011134208 @default.
- W3137050976 cites W3011955243 @default.
- W3137050976 cites W3012421327 @default.
- W3137050976 cites W3012515447 @default.
- W3137050976 cites W3012655019 @default.
- W3137050976 cites W3013125498 @default.
- W3137050976 cites W3013816672 @default.
- W3137050976 cites W3014003872 @default.
- W3137050976 cites W3014199470 @default.
- W3137050976 cites W3014361632 @default.
- W3137050976 cites W3015696390 @default.
- W3137050976 cites W3016785135 @default.
- W3137050976 cites W3017382495 @default.
- W3137050976 cites W3018108347 @default.
- W3137050976 cites W3018418935 @default.
- W3137050976 cites W3019022818 @default.
- W3137050976 cites W3022409605 @default.
- W3137050976 cites W3023496100 @default.
- W3137050976 cites W3024168867 @default.
- W3137050976 cites W3026328714 @default.
- W3137050976 cites W3026764413 @default.
- W3137050976 cites W3027047557 @default.
- W3137050976 cites W3029411887 @default.
- W3137050976 cites W3030609551 @default.
- W3137050976 cites W3031103686 @default.
- W3137050976 cites W3033134678 @default.
- W3137050976 cites W3033286755 @default.
- W3137050976 cites W3033400552 @default.
- W3137050976 cites W3034536136 @default.
- W3137050976 cites W3034696061 @default.
- W3137050976 cites W3035033705 @default.
- W3137050976 cites W3035791234 @default.
- W3137050976 cites W3036269403 @default.
- W3137050976 cites W3036642683 @default.
- W3137050976 cites W3041428032 @default.
- W3137050976 cites W3042206791 @default.
- W3137050976 cites W3043546104 @default.
- W3137050976 cites W3044909914 @default.
- W3137050976 cites W3046375353 @default.
- W3137050976 cites W3047099503 @default.
- W3137050976 cites W3047225781 @default.
- W3137050976 cites W3047265874 @default.
- W3137050976 cites W3048373952 @default.