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• W3137056319 endingPage "107725" @default.
• W3137056319 startingPage "107725" @default.
• W3137056319 abstract "As fungus-like protists, thraustochytrids have been increasingly studied for their faster growth rates and high lipid content. In the 1990s, thraustochytrids were used as docosahexaenoic acid (DHA) producers for the first time. Thraustochytrids genera, such as Thraustochytrium, Schizochytrium, and Aurantiochytrium have been developed and patented as industrial strains for DHA production. The high DHA yield is attributed to its unique and efficient polyketide-like synthase (PKS) pathway. Moreover, thraustochytrids possess a completed mevalonate (MVA) pathway, so it can be used as host for terpenoid production. In order to improve strain performance, the metabolic engineering strategies have been applied to promote or disrupt intracellular metabolic pathways, such as genetic engineering and addition of chemical activators. However, it is difficult to realize industrialization only by improving strain performance. Various operation strategies were developed to enlarge the production quantities from the laboratory-scale, including two-stage cultivation strategies, scale-up technologies and bioreactor design. Moreover, an economical and effective downstream process is also an important consideration for the industrial application of thraustochytrids. Downstream costs accounts for 20–60% of the overall process costs, which represents an attractive target for increasing the cost-competitiveness of thraustochytrids, including how to improve the efficiency of lipid extraction and the further application of biomass residues. This review aims to overview the whole lipid biotechnology of thraustochytrids to provide the background information for researchers." @default.
• W3137056319 created "2021-03-29" @default.
• W3137056319 creator A5007552901 @default.
• W3137056319 creator A5010323145 @default.
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• W3137056319 creator A5062520294 @default.
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• W3137056319 creator A5087015825 @default.
• W3137056319 date "2021-05-01" @default.
• W3137056319 modified "2023-10-17" @default.
• W3137056319 title "Biotechnological production of lipid and terpenoid from thraustochytrids" @default.
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