Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137079213> ?p ?o ?g. }
- W3137079213 endingPage "8238" @default.
- W3137079213 startingPage "8226" @default.
- W3137079213 abstract "A family of three water-soluble half-sandwich arene–ruthenium complexes, depicted as C1–C3, having the general formula [Ru(p-cymene)(L)Cl]Cl has been synthesized, where L represents (1H-benzo[d]imidazol-2-yl)guanidine (L1) or (benzo[d]oxazol-2-yl)guanidine (L2) or (benzo[d]thiazol-2-yl)guanidine (L3). The crystal structure of complex C3 has been determined. The complexes show several absorption bands in the visible and ultraviolet regions, and they also show prominent emission in the visible region while excited near 400 nm. Studies on the interaction of ligands L1–L3 and complexes C1–C3 with calf thymus DNA reveal that the complexes are better DNA binders than the ligands, which is attributable to the imposed planarity of the ruthenium-bound guanidine-based ligand, enabling it to serve as a better intercalator. Molecular docking studies show that the complexes effectively bind with DNA through electrostatic and H-bonding interactions and partial intercalation of the guanidine-based ligands. Cytotoxicity studies carried out on two carcinoma cell lines (PC3 and A549) and on two non-cancer cell lines (BPH1 and WI-38) show a marked improvement in antitumor activity owing to complex formation, which is attributed to improvement in cellular uptake on complex formation. The C1 complex is found to exhibit the most prominent activity against the PC3 cell line. Inclusion of the guanidine-based ligands in the half-sandwich ruthenium–arene complexes is found to be effective for displaying selective cytotoxicity to cancer cells and also for convenient tracing of the complexes in cells due to their prominent emissive nature." @default.
- W3137079213 created "2021-03-29" @default.
- W3137079213 creator A5003432347 @default.
- W3137079213 creator A5019238083 @default.
- W3137079213 creator A5025653739 @default.
- W3137079213 creator A5028837743 @default.
- W3137079213 creator A5054045080 @default.
- W3137079213 creator A5088354240 @default.
- W3137079213 date "2021-03-19" @default.
- W3137079213 modified "2023-10-11" @default.
- W3137079213 title "Utilization of Guanidine-Based Ancillary Ligands in Arene–Ruthenium Complexes for Selective Cytotoxicity" @default.
- W3137079213 cites W1178498256 @default.
- W3137079213 cites W1967037562 @default.
- W3137079213 cites W1979555212 @default.
- W3137079213 cites W1981017557 @default.
- W3137079213 cites W1983311859 @default.
- W3137079213 cites W1983649348 @default.
- W3137079213 cites W1987604182 @default.
- W3137079213 cites W1988802082 @default.
- W3137079213 cites W1995208785 @default.
- W3137079213 cites W2001520297 @default.
- W3137079213 cites W2002545310 @default.
- W3137079213 cites W2003381115 @default.
- W3137079213 cites W2006120627 @default.
- W3137079213 cites W2007666703 @default.
- W3137079213 cites W2010713697 @default.
- W3137079213 cites W2011284056 @default.
- W3137079213 cites W2017356685 @default.
- W3137079213 cites W2018887480 @default.
- W3137079213 cites W2020176511 @default.
- W3137079213 cites W2028698243 @default.
- W3137079213 cites W2030647969 @default.
- W3137079213 cites W2034555252 @default.
- W3137079213 cites W2037236039 @default.
- W3137079213 cites W2038492689 @default.
- W3137079213 cites W2042884376 @default.
- W3137079213 cites W2043465974 @default.
- W3137079213 cites W2052597764 @default.
- W3137079213 cites W2053726603 @default.
- W3137079213 cites W2060933041 @default.
- W3137079213 cites W2064894863 @default.
- W3137079213 cites W2065402334 @default.
- W3137079213 cites W2069166946 @default.
- W3137079213 cites W2072278652 @default.
- W3137079213 cites W2075444780 @default.
- W3137079213 cites W2087372927 @default.
- W3137079213 cites W2092629964 @default.
- W3137079213 cites W2094885475 @default.
- W3137079213 cites W2129905480 @default.
- W3137079213 cites W2131350133 @default.
- W3137079213 cites W2138078527 @default.
- W3137079213 cites W2145199943 @default.
- W3137079213 cites W2163257639 @default.
- W3137079213 cites W2312183083 @default.
- W3137079213 cites W2318540074 @default.
- W3137079213 cites W2333243467 @default.
- W3137079213 cites W2334594335 @default.
- W3137079213 cites W2487809975 @default.
- W3137079213 cites W2561391360 @default.
- W3137079213 cites W2590029327 @default.
- W3137079213 cites W2605996598 @default.
- W3137079213 cites W2609773660 @default.
- W3137079213 cites W2623488151 @default.
- W3137079213 cites W2705717199 @default.
- W3137079213 cites W2726771194 @default.
- W3137079213 cites W2736390504 @default.
- W3137079213 cites W2740916197 @default.
- W3137079213 cites W2741716724 @default.
- W3137079213 cites W2761697812 @default.
- W3137079213 cites W2765171483 @default.
- W3137079213 cites W2765748845 @default.
- W3137079213 cites W2769729017 @default.
- W3137079213 cites W2770473333 @default.
- W3137079213 cites W2785900358 @default.
- W3137079213 cites W2787263985 @default.
- W3137079213 cites W2787270596 @default.
- W3137079213 cites W2787580807 @default.
- W3137079213 cites W2788067393 @default.
- W3137079213 cites W2789751387 @default.
- W3137079213 cites W2793043310 @default.
- W3137079213 cites W2794580492 @default.
- W3137079213 cites W2885264971 @default.
- W3137079213 cites W2888831930 @default.
- W3137079213 cites W2896181316 @default.
- W3137079213 cites W2899457091 @default.
- W3137079213 cites W2900765620 @default.
- W3137079213 cites W2903519384 @default.
- W3137079213 cites W2906995004 @default.
- W3137079213 cites W2909963991 @default.
- W3137079213 cites W2910333849 @default.
- W3137079213 cites W2910941984 @default.
- W3137079213 cites W2912924089 @default.
- W3137079213 cites W2924135673 @default.
- W3137079213 cites W2929636092 @default.
- W3137079213 cites W2954095911 @default.
- W3137079213 cites W2955835283 @default.
- W3137079213 cites W2963246923 @default.
- W3137079213 cites W2979707872 @default.