FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137123045> ?p ?o ?g. }

• W3137123045 abstract "Abstract Background Little is known about the complex interactions between the diet, the gut microbiota, and enteropathogens. Here, the impact of two specific diets on the composition of the mouse gut microbiota and on the transcriptional response of Salmonella Typhimurium ( S. Typhimurium) was analyzed in an enteritis model. Results Mice were fed for two weeks a fibre-rich, plant-based diet (PD), or a Westernized diet (WD) rich in animal fat and proteins and in simple sugars, and then infected with an invasin-negative S . Typhimurium strain ST4/74 following streptomycin-treatment. Seventy-two hours post infection, fecal pathogen loads were equal in both diet groups, suggesting that neither of the diets had negatively influenced the ability of this ST4/74 strain to colonize and proliferate in the gut at this time point. To define its diet-dependent gene expression pattern, S. Typhimurium was immunomagnetically isolated from the gut content, and its transcriptome was analyzed. A total of 66 genes were more strongly expressed in mice fed the plant-based diet. The majority of these genes was involved in metabolic functions degrading substrates of fruits and plants. Four of them are part of the gat gene cluster responsible for the uptake and metabolism of galactitol and D-tagatose. In line with this finding, 16S rRNA gene amplicon analysis revealed higher relative abundance of bacterial families able to degrade fiber and nutritive carbohydrates in PD-fed mice in comparison with those nourished with a WD. Competitive mice infection experiments performed with strain ST4/74 and ST4/74 ΔSTM3254 lacking tagatose-1,6-biphosphate aldolase, which is essential for galactitol and tagatose utilization, did not reveal a growth advantage of strain ST4/74 in the gastrointestinal tract of mice fed plant-based diet as compared to the deletion mutant. Conclusion A Westernized diet and a plant-based diet evoke distinct transcriptional responses of S. Typhimurium during infection that allows the pathogen to adapt its metabolic activities to the diet-derived nutrients. This study therefore provides new insights into the dynamic interplay between nutrient availability, indigenous gut microbiota, and proliferation of S. Typhimurium." @default.
• W3137123045 created "2021-03-29" @default.
• W3137123045 creator A5013309617 @default.
• W3137123045 creator A5038703910 @default.
• W3137123045 creator A5046665812 @default.
• W3137123045 creator A5074238607 @default.
• W3137123045 creator A5083259047 @default.
• W3137123045 creator A5089944172 @default.
• W3137123045 date "2021-03-17" @default.
• W3137123045 modified "2023-10-08" @default.
• W3137123045 title "A diet-specific microbiota drives Salmonella Typhimurium to adapt its in vivo response to plant-derived substrates" @default.
• W3137123045 cites W1804759123 @default.
• W3137123045 cites W1878295921 @default.
• W3137123045 cites W1905099113 @default.
• W3137123045 cites W1906797173 @default.
• W3137123045 cites W1923462270 @default.
• W3137123045 cites W1963531377 @default.
• W3137123045 cites W1965501527 @default.
• W3137123045 cites W1968105193 @default.
• W3137123045 cites W1975873354 @default.
• W3137123045 cites W1983555394 @default.
• W3137123045 cites W1991497480 @default.
• W3137123045 cites W1994896583 @default.
• W3137123045 cites W2005440641 @default.
• W3137123045 cites W2008758799 @default.
• W3137123045 cites W2024126967 @default.
• W3137123045 cites W2026894676 @default.
• W3137123045 cites W2034090239 @default.
• W3137123045 cites W2044533997 @default.
• W3137123045 cites W2054691507 @default.
• W3137123045 cites W2060196294 @default.
• W3137123045 cites W2067791097 @default.
• W3137123045 cites W2071426011 @default.
• W3137123045 cites W2073332363 @default.
• W3137123045 cites W2077072558 @default.
• W3137123045 cites W2077105787 @default.
• W3137123045 cites W2083501377 @default.
• W3137123045 cites W2087278385 @default.
• W3137123045 cites W2087292184 @default.
• W3137123045 cites W2088833470 @default.
• W3137123045 cites W2095782520 @default.
• W3137123045 cites W2101016096 @default.
• W3137123045 cites W2105937617 @default.
• W3137123045 cites W2109874624 @default.
• W3137123045 cites W2114089110 @default.
• W3137123045 cites W2114392707 @default.
• W3137123045 cites W2114408988 @default.
• W3137123045 cites W2115701239 @default.
• W3137123045 cites W2116137883 @default.
• W3137123045 cites W2116802300 @default.
• W3137123045 cites W2118085294 @default.
• W3137123045 cites W2120459847 @default.
• W3137123045 cites W2124519481 @default.
• W3137123045 cites W2125313483 @default.
• W3137123045 cites W2129994723 @default.
• W3137123045 cites W2131902769 @default.
• W3137123045 cites W2136482257 @default.
• W3137123045 cites W2136879569 @default.
• W3137123045 cites W2143563471 @default.
• W3137123045 cites W2152885278 @default.
• W3137123045 cites W2166581710 @default.
• W3137123045 cites W2167090556 @default.
• W3137123045 cites W2167591869 @default.
• W3137123045 cites W2169165033 @default.
• W3137123045 cites W2170488656 @default.
• W3137123045 cites W2214388745 @default.
• W3137123045 cites W2328804149 @default.
• W3137123045 cites W2484230073 @default.
• W3137123045 cites W2522919408 @default.
• W3137123045 cites W2563609301 @default.
• W3137123045 cites W2567855423 @default.
• W3137123045 cites W2578250538 @default.
• W3137123045 cites W2747850017 @default.
• W3137123045 cites W2771212236 @default.
• W3137123045 cites W2920541859 @default.
• W3137123045 cites W2977495908 @default.
• W3137123045 cites W4254928341 @default.
• W3137123045 cites W4296765338 @default.
• W3137123045 doi "https://doi.org/10.1186/s42523-021-00082-8" @default.
• W3137123045 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7972205" @default.
• W3137123045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33731218" @default.
• W3137123045 hasPublicationYear "2021" @default.
• W3137123045 type Work @default.
• W3137123045 sameAs 3137123045 @default.
• W3137123045 citedByCount "5" @default.
• W3137123045 countsByYear W31371230452021 @default.
• W3137123045 countsByYear W31371230452022 @default.
• W3137123045 countsByYear W31371230452023 @default.
• W3137123045 crossrefType "journal-article" @default.
• W3137123045 hasAuthorship W3137123045A5013309617 @default.
• W3137123045 hasAuthorship W3137123045A5038703910 @default.
• W3137123045 hasAuthorship W3137123045A5046665812 @default.
• W3137123045 hasAuthorship W3137123045A5074238607 @default.
• W3137123045 hasAuthorship W3137123045A5083259047 @default.
• W3137123045 hasAuthorship W3137123045A5089944172 @default.
• W3137123045 hasBestOaLocation W31371230451 @default.
• W3137123045 hasConcept C104317684 @default.
• W3137123045 hasConcept C105702510 @default.
• W3137123045 hasConcept C150194340 @default.
• W3137123045 hasConcept C162317418 @default.

• next