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- W3137133047 abstract "Since the dawn of civilization, man has demonstrated understanding of, and the ability to exploit, the concept of heredity. The earliest known evidence of selective breeding dates to the Mesolithic era, and a 6000-year-old tablet from Babylon shows a horse pedigree containing suggestions of the species’ hereditary traits1. Despite lacking a physical or chemical explanation of the substance transferred from parent to offspring, Gregor Mendel’s 1865 paper2, which defined the laws of monogenetic heredity, gave an indication of its existence. Around the same time, Francis Galton, a cousin of Charles Darwin, evaluated the effect of nature versus nurture through a considerable number of family and twin studies3. The work of the 2 scientists eventually gave rise to 2 fundamentally different views on heredity, with the critics of Mendelian inheritance arguing that it could not possibly explain traits displaying extreme individual variation in a population, such as stature. The dispute was finally resolved in 1918, when R.A. Fisher4 elegantly demonstrated that when a large number of genes with a Mendelian inheritance pattern act on top of each other, the result is a normally distributed variation in the characteristic, such as that seen for stature. Today, a century after Fisher’s publication, we have only just begun to comprehend the magnitude of genetic factors influencing a particular phenotype. For many complex diseases, hundreds or thousands of single-nucleotide polymorphisms (SNP) appear to be involved in the etiology5, each typically with an almost negligible effect size. With this realization, the early hopes that genome-wide association studies (GWAS) would lead to the identification of persons at risk of a particular disease, ultimately allowing new preventive and therapeutic strategies, were frustrated6. Thus, there remains a critical need for the development of new methods that integrate the … Address correspondence to Dr. S. Reid, Uppsala University, Medical Sciences, Akademiska sjukhuset, Ingång 40, 5 tr, 751 85 Uppsala, Sweden. Email: sarah.reid{at}medsci.uu.se." @default.
- W3137133047 created "2021-03-29" @default.
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- W3137133047 date "2021-03-15" @default.
- W3137133047 modified "2023-10-16" @default.
- W3137133047 title "From Prehistory to Precision Medicine: Are Genetic Risk Scores Our Next Step?" @default.
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- W3137133047 doi "https://doi.org/10.3899/jrheum.201256" @default.
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