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- W31371711 abstract "Hypoxia is a very important feature of tumors, especially for solid tumors, and it was demonstrated highly relevant with aggressive biology, including anti-apoptosis, vasculogenesis and radiation or chemotherapy resistance. Correlatively, hypoxia-inducible factors 1-α (HIF-1α), which the wildest contribution of hypoxia-inducible factors (HIFs), plays a crucial role in the adaptation of tumor cells to hypoxia via upregulating the transcription of the oncogene and downregulating the transcription of suppressor gene. This review focus on the HIF-1α regulation including hydroxylation and acetylation, growth factors pathway, heat shock proteins(HSPs), and small molecule inhibitors for HIF-1α directly or indirectly." @default.
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- W31371711 date "1986-01-01" @default.
- W31371711 modified "2023-10-07" @default.
- W31371711 title "Hypoxia-mediated nitro-heterocyclic drugs in the radio- and chemotherapy of cancer" @default.
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- W31371711 doi "https://doi.org/10.1016/0006-2952(86)90560-5" @default.
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