Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137171812> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W3137171812 endingPage "337" @default.
- W3137171812 startingPage "333" @default.
- W3137171812 abstract "We report a case of a 60-year-old male with metachronous primary malignancies, pancreatic cancer and malignant melanoma which recurred simultaneously. Both cancers were challenging to diagnose and throughout the case at different times, the presence of two active malignancies obscured the clinical picture. A bleeding gastric lesion found in the stomach 6 months after a distal pancreatectomy for pancreatic adenocarcinoma revealed metastatic melanoma, presumed secondary from a melanoma excised from the patient’s back 2 years previously. During surgery intended to resect the gastric lesion, peritoneal nodularity was identified, with histology confirming metastatic pancreas cancer. This case highlights two main points of interest. Firstly it emphasises the role for consideration of a genetic predisposition in young patients with more than one primary malignancy. The man in this case was not informed of his family history as he was adopted. If he had knowledge of previous family history, he may have been able to provide information to expedite arrival at the diagnosis of a CDKN2A mutation (melanoma-pancreatic carcinoma syndrome). In addition, this case also raises the issue of the challenges we face when treating synchronous primary malignancies. The two malignancies here behaved equally aggressively and posed obstacles for treatment as there is no mutual method of carcinogenesis that could be targeted with treatment; therefore, treatment modalities had to be chosen to treat each malignancy separately. To date, studies evaluating the role for targeted therapy in the setting of CDKN2A mutations have not conclusively provided meaningful benefits to patients." @default.
- W3137171812 created "2021-03-29" @default.
- W3137171812 creator A5063081560 @default.
- W3137171812 creator A5066922986 @default.
- W3137171812 creator A5080599699 @default.
- W3137171812 date "2021-03-03" @default.
- W3137171812 modified "2023-10-18" @default.
- W3137171812 title "Synchronous Melanoma and Pancreas Malignancies Leading to a Discovery of a CDKN2A Mutation in a Patient with No Known Family History" @default.
- W3137171812 cites W1964180263 @default.
- W3137171812 cites W1989412643 @default.
- W3137171812 cites W2022779163 @default.
- W3137171812 cites W2170335597 @default.
- W3137171812 cites W2285588397 @default.
- W3137171812 cites W23100725 @default.
- W3137171812 cites W2410675151 @default.
- W3137171812 cites W2805575723 @default.
- W3137171812 cites W2895255285 @default.
- W3137171812 doi "https://doi.org/10.1159/000512999" @default.
- W3137171812 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7983569" @default.
- W3137171812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33776725" @default.
- W3137171812 hasPublicationYear "2021" @default.
- W3137171812 type Work @default.
- W3137171812 sameAs 3137171812 @default.
- W3137171812 citedByCount "0" @default.
- W3137171812 crossrefType "journal-article" @default.
- W3137171812 hasAuthorship W3137171812A5063081560 @default.
- W3137171812 hasAuthorship W3137171812A5066922986 @default.
- W3137171812 hasAuthorship W3137171812A5080599699 @default.
- W3137171812 hasBestOaLocation W31371718121 @default.
- W3137171812 hasConcept C121608353 @default.
- W3137171812 hasConcept C126322002 @default.
- W3137171812 hasConcept C126838900 @default.
- W3137171812 hasConcept C143998085 @default.
- W3137171812 hasConcept C2777658100 @default.
- W3137171812 hasConcept C2778764654 @default.
- W3137171812 hasConcept C2779399171 @default.
- W3137171812 hasConcept C2780210213 @default.
- W3137171812 hasConcept C2780265364 @default.
- W3137171812 hasConcept C2781179581 @default.
- W3137171812 hasConcept C2781182431 @default.
- W3137171812 hasConcept C502942594 @default.
- W3137171812 hasConcept C71924100 @default.
- W3137171812 hasConceptScore W3137171812C121608353 @default.
- W3137171812 hasConceptScore W3137171812C126322002 @default.
- W3137171812 hasConceptScore W3137171812C126838900 @default.
- W3137171812 hasConceptScore W3137171812C143998085 @default.
- W3137171812 hasConceptScore W3137171812C2777658100 @default.
- W3137171812 hasConceptScore W3137171812C2778764654 @default.
- W3137171812 hasConceptScore W3137171812C2779399171 @default.
- W3137171812 hasConceptScore W3137171812C2780210213 @default.
- W3137171812 hasConceptScore W3137171812C2780265364 @default.
- W3137171812 hasConceptScore W3137171812C2781179581 @default.
- W3137171812 hasConceptScore W3137171812C2781182431 @default.
- W3137171812 hasConceptScore W3137171812C502942594 @default.
- W3137171812 hasConceptScore W3137171812C71924100 @default.
- W3137171812 hasIssue "1" @default.
- W3137171812 hasLocation W31371718121 @default.
- W3137171812 hasLocation W31371718122 @default.
- W3137171812 hasOpenAccess W3137171812 @default.
- W3137171812 hasPrimaryLocation W31371718121 @default.
- W3137171812 hasRelatedWork W2423512054 @default.
- W3137171812 hasRelatedWork W2442116491 @default.
- W3137171812 hasRelatedWork W2802558989 @default.
- W3137171812 hasRelatedWork W2902148150 @default.
- W3137171812 hasRelatedWork W3158579529 @default.
- W3137171812 hasRelatedWork W4318192576 @default.
- W3137171812 hasRelatedWork W4318318110 @default.
- W3137171812 hasRelatedWork W4318321277 @default.
- W3137171812 hasRelatedWork W4319162155 @default.
- W3137171812 hasRelatedWork W4319232702 @default.
- W3137171812 hasVolume "14" @default.
- W3137171812 isParatext "false" @default.
- W3137171812 isRetracted "false" @default.
- W3137171812 magId "3137171812" @default.
- W3137171812 workType "article" @default.