FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137172330> ?p ?o ?g. }

• W3137172330 abstract "RNA N6-methyladenosine (m6A) modification is one of the main forms of posttranscriptional modification, and its dysregulation is involved in a series of pathological processes. RNA m6A regulators, which mediate dynamic RNA m6A modification, are expressed in almost all types of testicular cells, including spermatogenetic cells and somatic cells. Cumulative studies have found that knockout of RNA m6A regulators in the testis leads to abnormal metabolism of the target mRNAs, which eventually causes spermatogenetic disorders and infertility. To date, a role for dysregulated RNA m6A modification in human male infertility remains elusive; however, dysregulated expression of RNA m6A regulators in abnormal human semen samples, including oligospermia, asthenozoospermia and azoospermia, has been found. Therefore, we speculate that abnormal RNA m6A methylation may be an important mechanism of male infertility. In this review, we summarize the recent findings regarding the spatiotemporal expression of RNA m6A regulators in the testes, mechanisms of RNA m6A modification in spermatogenesis and the relation between dysregulated RNA m6A regulators and human male infertility. In addition, we also discuss future directions in studying the molecular mechanism of male infertility and exploring their clinical applications from the viewpoint of RNA m6A modification." @default.
• W3137172330 created "2021-03-29" @default.
• W3137172330 creator A5020586831 @default.
• W3137172330 creator A5066390742 @default.
• W3137172330 creator A5070226552 @default.
• W3137172330 date "2021-03-22" @default.
• W3137172330 modified "2023-10-05" @default.
• W3137172330 title "RNA N6-methyladenosine modification, spermatogenesis, and human male infertility" @default.
• W3137172330 cites W1588504618 @default.
• W3137172330 cites W1965049397 @default.
• W3137172330 cites W1977681950 @default.
• W3137172330 cites W1977742580 @default.
• W3137172330 cites W1981629946 @default.
• W3137172330 cites W1989683090 @default.
• W3137172330 cites W1991807334 @default.
• W3137172330 cites W2005568203 @default.
• W3137172330 cites W2011413382 @default.
• W3137172330 cites W2012311421 @default.
• W3137172330 cites W2026194232 @default.
• W3137172330 cites W2035069455 @default.
• W3137172330 cites W2036700699 @default.
• W3137172330 cites W2039916661 @default.
• W3137172330 cites W2048918307 @default.
• W3137172330 cites W2050902485 @default.
• W3137172330 cites W2061487074 @default.
• W3137172330 cites W2064841455 @default.
• W3137172330 cites W2071930821 @default.
• W3137172330 cites W2078964320 @default.
• W3137172330 cites W2085628607 @default.
• W3137172330 cites W2091235283 @default.
• W3137172330 cites W2091796431 @default.
• W3137172330 cites W2097660065 @default.
• W3137172330 cites W2102872651 @default.
• W3137172330 cites W2110426875 @default.
• W3137172330 cites W2122969281 @default.
• W3137172330 cites W2150857371 @default.
• W3137172330 cites W2165547003 @default.
• W3137172330 cites W2169345822 @default.
• W3137172330 cites W2251528878 @default.
• W3137172330 cites W2318545632 @default.
• W3137172330 cites W2331419903 @default.
• W3137172330 cites W2339217685 @default.
• W3137172330 cites W2342299314 @default.
• W3137172330 cites W2551247775 @default.
• W3137172330 cites W2563912688 @default.
• W3137172330 cites W2594027738 @default.
• W3137172330 cites W2604226893 @default.
• W3137172330 cites W2604767392 @default.
• W3137172330 cites W2616848081 @default.
• W3137172330 cites W2746255049 @default.
• W3137172330 cites W2749219966 @default.
• W3137172330 cites W2749562594 @default.
• W3137172330 cites W2750801274 @default.
• W3137172330 cites W2752985760 @default.
• W3137172330 cites W2754391888 @default.
• W3137172330 cites W2762814002 @default.
• W3137172330 cites W2765620447 @default.
• W3137172330 cites W2765787092 @default.
• W3137172330 cites W2769807951 @default.
• W3137172330 cites W2774934500 @default.
• W3137172330 cites W2776310795 @default.
• W3137172330 cites W2776540408 @default.
• W3137172330 cites W2780168233 @default.
• W3137172330 cites W2790194840 @default.
• W3137172330 cites W2790887288 @default.
• W3137172330 cites W2791349417 @default.
• W3137172330 cites W2791366345 @default.
• W3137172330 cites W2791933046 @default.
• W3137172330 cites W2792456762 @default.
• W3137172330 cites W2793246329 @default.
• W3137172330 cites W2801616360 @default.
• W3137172330 cites W2805506311 @default.
• W3137172330 cites W2805826733 @default.
• W3137172330 cites W2810825718 @default.
• W3137172330 cites W2883062882 @default.
• W3137172330 cites W2889446142 @default.
• W3137172330 cites W2893012608 @default.
• W3137172330 cites W2896760732 @default.
• W3137172330 cites W2898886894 @default.
• W3137172330 cites W2903232633 @default.
• W3137172330 cites W2905645086 @default.
• W3137172330 cites W2906611848 @default.
• W3137172330 cites W2910261752 @default.
• W3137172330 cites W2936790196 @default.
• W3137172330 cites W2949154878 @default.
• W3137172330 cites W2950126013 @default.
• W3137172330 cites W2951703498 @default.
• W3137172330 cites W2960813577 @default.
• W3137172330 cites W2962454748 @default.
• W3137172330 cites W2962780260 @default.
• W3137172330 cites W2969864448 @default.
• W3137172330 cites W2970224263 @default.
• W3137172330 cites W2970338144 @default.
• W3137172330 cites W2986873909 @default.
• W3137172330 cites W2990551615 @default.
• W3137172330 cites W2991175285 @default.
• W3137172330 cites W2993072683 @default.
• W3137172330 cites W2993675487 @default.
• W3137172330 cites W2994705631 @default.
• W3137172330 cites W2998011509 @default.

• next