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• W3137178836 endingPage "694" @default.
• W3137178836 startingPage "694" @default.
• W3137178836 abstract "Autophagy is an evolutionarily conserved degradation process maintaining cell homeostasis. Induction of autophagy is triggered as a response to a broad range of cellular stress conditions, such as nutrient deprivation, protein aggregation, organelle damage and pathogen invasion. Macroautophagy involves the sequestration of cytoplasmic contents in a double-membrane organelle referred to as the autophagosome with subsequent degradation of its contents upon delivery to lysosomes. Autophagy plays critical roles in development, maintenance and survival of distinct cell populations including neurons. Consequently, age-dependent decline in autophagy predisposes animals for age-related diseases including neurodegeneration and compromises healthspan and longevity. In this review, we summarize recent advances in our understanding of the role of neuronal autophagy in ageing, focusing on studies in the nematode Caenorhabditis elegans." @default.
• W3137178836 created "2021-03-29" @default.
• W3137178836 creator A5071420074 @default.
• W3137178836 creator A5091629393 @default.
• W3137178836 date "2021-03-21" @default.
• W3137178836 modified "2023-09-26" @default.
• W3137178836 title "Molecular Basis of Neuronal Autophagy in Ageing: Insights from Caenorhabditis elegans" @default.
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