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- W3137203679 abstract "Abstract Cell membranes regulate the distribution of biological machinery between phase-separated lipid domains to facilitate key processes including signalling and transport, which are among the life-like functionalities that bottom-up synthetic biology aims to replicate in artificial-cellular systems. Here, we introduce a modular approach to program partitioning of amphiphilic DNA nanostructures in co-existing lipid domains. Exploiting the tendency of different hydrophobic “anchors” to enrich different phases, we modulate the lateral distribution of our devices by rationally combining hydrophobes, and by changing nanostructure size and its topology. We demonstrate the functionality of our strategy with a bio-inspired DNA architecture, which dynamically undergoes ligand-induced reconfiguration to mediate cargo transport between domains via lateral re-distribution. Our findings pave the way to next-generation biomimetic platforms for sensing, transduction, and communication in synthetic cellular systems." @default.
- W3137203679 created "2021-03-29" @default.
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- W3137203679 date "2021-03-02" @default.
- W3137203679 modified "2023-09-26" @default.
- W3137203679 title "A modular, dynamic, DNA-based platform for regulating cargo distribution and transport between lipid domains" @default.
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- W3137203679 doi "https://doi.org/10.1101/2021.03.02.433457" @default.
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