FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137218900> ?p ?o ?g. }

• W3137218900 abstract "Abstract Background Infection with Salmonella enterica serovars Typhi and Paratyphi A cause an estimated 14 million cases of enteric fever annually. Here the controlled nature of challenge studies is exploited to identify genetic variants associated with enteric fever susceptibility. Methods Human challenge participants were genotyped by Illumina OmniExpress-24 BeadChip array (n=176) and/or transcriptionally profiled by RNA-sequencing (n=178). Results Two SNPs within CAPN14 and MIATNB were identified with p<10 −5 for association with development of symptoms or bacteraemia following oral S . Typhi or S . Paratyphi A challenge. Imputation of classical human leukocyte antigen (HLA) types from genomic and transcriptomic data identified HLA-B*27:05, previously associated with non-typhoidal Salmonella -induced reactive arthritis, as the HLA type most strongly associated with enteric fever susceptibility (p=0.012). Genes related to the unfolded protein response and heat shock were over-represented in HLA-B*27:05 + participants following challenge (p=0.01). Furthermore, intracellular replication of S . Typhi is higher in C1R cells transfected with HLA-B*27:05 (p=0.02). Conclusion These data suggest that activation of the unfolded protein response by HLA-B*27:05 misfolding may create an intracellular environment conducive to S . Typhi replication, increasing susceptibility to enteric fever." @default.
• W3137218900 created "2021-03-29" @default.
• W3137218900 creator A5009689378 @default.
• W3137218900 creator A5014008737 @default.
• W3137218900 creator A5023032597 @default.
• W3137218900 creator A5024501463 @default.
• W3137218900 creator A5026977941 @default.
• W3137218900 creator A5043701861 @default.
• W3137218900 creator A5044457630 @default.
• W3137218900 creator A5046858200 @default.
• W3137218900 creator A5055071592 @default.
• W3137218900 creator A5058155843 @default.
• W3137218900 creator A5067034561 @default.
• W3137218900 creator A5069612115 @default.
• W3137218900 creator A5073282795 @default.
• W3137218900 creator A5081341378 @default.
• W3137218900 creator A5083917121 @default.
• W3137218900 date "2021-03-19" @default.
• W3137218900 modified "2023-10-17" @default.
• W3137218900 title "Genetic Susceptibility to Enteric Fever in Experimentally Challenged Human Volunteers" @default.
• W3137218900 cites W1504595291 @default.
• W3137218900 cites W1513917224 @default.
• W3137218900 cites W1768132278 @default.
• W3137218900 cites W1986428805 @default.
• W3137218900 cites W1987470985 @default.
• W3137218900 cites W1989508933 @default.
• W3137218900 cites W1991429083 @default.
• W3137218900 cites W1993723956 @default.
• W3137218900 cites W2055577456 @default.
• W3137218900 cites W2075788735 @default.
• W3137218900 cites W2098951833 @default.
• W3137218900 cites W2104549677 @default.
• W3137218900 cites W2123106908 @default.
• W3137218900 cites W2126372418 @default.
• W3137218900 cites W2130410032 @default.
• W3137218900 cites W2132702000 @default.
• W3137218900 cites W2161633633 @default.
• W3137218900 cites W2169456326 @default.
• W3137218900 cites W2169463839 @default.
• W3137218900 cites W2210846281 @default.
• W3137218900 cites W2398199165 @default.
• W3137218900 cites W2510065326 @default.
• W3137218900 cites W2516066095 @default.
• W3137218900 cites W2580861314 @default.
• W3137218900 cites W2584925611 @default.
• W3137218900 cites W2622731166 @default.
• W3137218900 cites W2795282977 @default.
• W3137218900 cites W2898231027 @default.
• W3137218900 cites W2917067204 @default.
• W3137218900 cites W2958015815 @default.
• W3137218900 doi "https://doi.org/10.1101/2021.03.19.436030" @default.
• W3137218900 hasPublicationYear "2021" @default.
• W3137218900 type Work @default.
• W3137218900 sameAs 3137218900 @default.
• W3137218900 citedByCount "0" @default.
• W3137218900 crossrefType "posted-content" @default.
• W3137218900 hasAuthorship W3137218900A5009689378 @default.
• W3137218900 hasAuthorship W3137218900A5014008737 @default.
• W3137218900 hasAuthorship W3137218900A5023032597 @default.
• W3137218900 hasAuthorship W3137218900A5024501463 @default.
• W3137218900 hasAuthorship W3137218900A5026977941 @default.
• W3137218900 hasAuthorship W3137218900A5043701861 @default.
• W3137218900 hasAuthorship W3137218900A5044457630 @default.
• W3137218900 hasAuthorship W3137218900A5046858200 @default.
• W3137218900 hasAuthorship W3137218900A5055071592 @default.
• W3137218900 hasAuthorship W3137218900A5058155843 @default.
• W3137218900 hasAuthorship W3137218900A5067034561 @default.
• W3137218900 hasAuthorship W3137218900A5069612115 @default.
• W3137218900 hasAuthorship W3137218900A5073282795 @default.
• W3137218900 hasAuthorship W3137218900A5081341378 @default.
• W3137218900 hasAuthorship W3137218900A5083917121 @default.
• W3137218900 hasBestOaLocation W31372189001 @default.
• W3137218900 hasConcept C104317684 @default.
• W3137218900 hasConcept C135763542 @default.
• W3137218900 hasConcept C147483822 @default.
• W3137218900 hasConcept C153209595 @default.
• W3137218900 hasConcept C159047783 @default.
• W3137218900 hasConcept C188280979 @default.
• W3137218900 hasConcept C203014093 @default.
• W3137218900 hasConcept C2779607309 @default.
• W3137218900 hasConcept C2781065037 @default.
• W3137218900 hasConcept C2994552716 @default.
• W3137218900 hasConcept C3020771617 @default.
• W3137218900 hasConcept C520601542 @default.
• W3137218900 hasConcept C523546767 @default.
• W3137218900 hasConcept C54355233 @default.
• W3137218900 hasConcept C547475151 @default.
• W3137218900 hasConcept C67636389 @default.
• W3137218900 hasConcept C86803240 @default.
• W3137218900 hasConcept C89423630 @default.
• W3137218900 hasConceptScore W3137218900C104317684 @default.
• W3137218900 hasConceptScore W3137218900C135763542 @default.
• W3137218900 hasConceptScore W3137218900C147483822 @default.
• W3137218900 hasConceptScore W3137218900C153209595 @default.
• W3137218900 hasConceptScore W3137218900C159047783 @default.
• W3137218900 hasConceptScore W3137218900C188280979 @default.
• W3137218900 hasConceptScore W3137218900C203014093 @default.
• W3137218900 hasConceptScore W3137218900C2779607309 @default.
• W3137218900 hasConceptScore W3137218900C2781065037 @default.
• W3137218900 hasConceptScore W3137218900C2994552716 @default.

• next