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- W3137220512 startingPage "503352" @default.
- W3137220512 abstract "The potential of apigenin (APG) to enhance cisplatin’s (CDDP) chemotherapeutic efficacy was investigated in HepG2, Hep3B, and Huh7 liver cancer cell lines. The presence of 20 μM APG sensitized all cell lines to CDDP treatment (degree of sensitization based on the MTT assay: HepG2>Huh7>Hep3B). As reflected by sister chromatid exchange levels, the degree of genetic instability as well as DNA repair by homologous recombination differed among cell lines. CDDP and 20 μM APG cotreatment exhibited a synergistic genotoxic effect on Hep3B cells and a less than additive effect on HepG2 and Huh7 cells. Cell cycle delays were noticed during the first mitotic division in Hep3B and Huh7 cells and the second mitotic division in HepG2 cells. CDDP and CDDP + APG treatments reduced the clonogenic capacity of all cell lines; however, there was a discordance in drug sensitivity compared with the MMT assay. Furthermore, a senescence-like phenotype was induced, especially in Hep3B and Huh7 cells. Unlike CDDP monotherapy, the combined treatment exhibited a significant anti-invasive and anti-migratory action in all cancer cell lines. The fact that the three liver cancer cell lines responded differently, yet positively, to CDDP + APG cotreatment could be attributed to variations they present in gene expression. Complex mechanisms seem to influence cellular responses and cell fate." @default.
- W3137220512 created "2021-03-29" @default.
- W3137220512 creator A5017168463 @default.
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- W3137220512 date "2021-06-01" @default.
- W3137220512 modified "2023-10-01" @default.
- W3137220512 title "Differential effects of cisplatin combined with the flavonoid apigenin on HepG2, Hep3B, and Huh7 liver cancer cell lines" @default.
- W3137220512 cites W1435191252 @default.
- W3137220512 cites W1484740038 @default.
- W3137220512 cites W1531823089 @default.
- W3137220512 cites W1553367038 @default.
- W3137220512 cites W1657803481 @default.
- W3137220512 cites W1867768655 @default.
- W3137220512 cites W1886613766 @default.
- W3137220512 cites W1965324768 @default.
- W3137220512 cites W1965688832 @default.
- W3137220512 cites W1966098047 @default.
- W3137220512 cites W1966825260 @default.
- W3137220512 cites W1966829974 @default.
- W3137220512 cites W1966841369 @default.
- W3137220512 cites W1966913795 @default.
- W3137220512 cites W1968777135 @default.
- W3137220512 cites W1970516269 @default.
- W3137220512 cites W1971100617 @default.
- W3137220512 cites W1976362728 @default.
- W3137220512 cites W1977013181 @default.
- W3137220512 cites W1977588029 @default.
- W3137220512 cites W1985319895 @default.
- W3137220512 cites W1987370132 @default.
- W3137220512 cites W1990161819 @default.
- W3137220512 cites W1991961027 @default.
- W3137220512 cites W1994579379 @default.
- W3137220512 cites W1997312624 @default.
- W3137220512 cites W1997755728 @default.
- W3137220512 cites W2001953597 @default.
- W3137220512 cites W2002597275 @default.
- W3137220512 cites W2003137573 @default.
- W3137220512 cites W2004125597 @default.
- W3137220512 cites W2004446628 @default.
- W3137220512 cites W2005155951 @default.
- W3137220512 cites W2008650297 @default.
- W3137220512 cites W2010711320 @default.
- W3137220512 cites W2011257176 @default.
- W3137220512 cites W2013860287 @default.
- W3137220512 cites W2015933637 @default.
- W3137220512 cites W2019741010 @default.
- W3137220512 cites W2022652364 @default.
- W3137220512 cites W2023942118 @default.
- W3137220512 cites W2026513162 @default.
- W3137220512 cites W2029712420 @default.
- W3137220512 cites W2035889318 @default.
- W3137220512 cites W2042329244 @default.
- W3137220512 cites W2042418128 @default.
- W3137220512 cites W2045776270 @default.
- W3137220512 cites W2046603236 @default.
- W3137220512 cites W2047957855 @default.
- W3137220512 cites W2050224146 @default.
- W3137220512 cites W2050244937 @default.
- W3137220512 cites W2050345170 @default.
- W3137220512 cites W2051768809 @default.
- W3137220512 cites W2052728502 @default.
- W3137220512 cites W2053727025 @default.
- W3137220512 cites W2055021348 @default.
- W3137220512 cites W2055489382 @default.
- W3137220512 cites W2055915044 @default.
- W3137220512 cites W2058965120 @default.
- W3137220512 cites W2059002036 @default.
- W3137220512 cites W2060932390 @default.
- W3137220512 cites W2062438365 @default.
- W3137220512 cites W2063684625 @default.
- W3137220512 cites W2064477710 @default.
- W3137220512 cites W2066419333 @default.
- W3137220512 cites W2067623093 @default.
- W3137220512 cites W2068751269 @default.
- W3137220512 cites W2071590728 @default.
- W3137220512 cites W2072585523 @default.
- W3137220512 cites W2072626928 @default.
- W3137220512 cites W2074618914 @default.
- W3137220512 cites W2074638597 @default.
- W3137220512 cites W2074951329 @default.
- W3137220512 cites W2075941074 @default.
- W3137220512 cites W2076961963 @default.
- W3137220512 cites W2077264029 @default.
- W3137220512 cites W2080125477 @default.
- W3137220512 cites W2083974327 @default.
- W3137220512 cites W2085210597 @default.
- W3137220512 cites W2091236187 @default.
- W3137220512 cites W2095243258 @default.
- W3137220512 cites W2095435093 @default.
- W3137220512 cites W2102627969 @default.
- W3137220512 cites W2109630092 @default.