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- W3137239013 startingPage "3208" @default.
- W3137239013 abstract "Endoglin (CD105) is a type-1 integral transmembrane glycoprotein and coreceptor for transforming growth factor-β (TGF-β) ligands. The endoglin/TGF-β signaling pathway regulates hemostasis, cell proliferation/migration, extracellular matrix (ECM) synthesis and angiogenesis. Angiogenesis contributes to early progression, invasion, postoperative recurrence, and metastasis in hepatocellular carcinoma (HCC), one of the most widespread malignancies globally. Endoglin is overexpressed in newly formed HCC microvessels. It increases microvessel density in cirrhotic and regenerative HCC nodules. In addition, circulating endoglin is present in HCC patients, suggesting potential for use as a diagnostic or prognostic factor. HCC angiogenesis is dynamic and endoglin expression varies by stage. TRC105 (carotuximab) is an antibody against endoglin, and three of its clinical trials were related to liver diseases. A partial response was achieved when combining TRC105 with sorafenib. Although antiangiogenic therapy still carries some risks, combination therapy with endoglin inhibitors or other targeted therapies holds promise." @default.
- W3137239013 created "2021-03-29" @default.
- W3137239013 creator A5008965000 @default.
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- W3137239013 creator A5046897957 @default.
- W3137239013 creator A5055032095 @default.
- W3137239013 creator A5091107747 @default.
- W3137239013 date "2021-03-22" @default.
- W3137239013 modified "2023-10-14" @default.
- W3137239013 title "The Role of Endoglin in Hepatocellular Carcinoma" @default.
- W3137239013 cites W1523878042 @default.
- W3137239013 cites W1568010007 @default.
- W3137239013 cites W1577109893 @default.
- W3137239013 cites W1590052782 @default.
- W3137239013 cites W1815742699 @default.
- W3137239013 cites W1966915736 @default.
- W3137239013 cites W1968181166 @default.
- W3137239013 cites W1978003340 @default.
- W3137239013 cites W1983653170 @default.
- W3137239013 cites W1985542042 @default.
- W3137239013 cites W1996141843 @default.
- W3137239013 cites W2002449187 @default.
- W3137239013 cites W2002606648 @default.
- W3137239013 cites W2005848686 @default.
- W3137239013 cites W2009522838 @default.
- W3137239013 cites W2009802960 @default.
- W3137239013 cites W2011285940 @default.
- W3137239013 cites W2011525358 @default.
- W3137239013 cites W201326763 @default.
- W3137239013 cites W2013958991 @default.
- W3137239013 cites W2022211980 @default.
- W3137239013 cites W2022250158 @default.
- W3137239013 cites W2022659261 @default.
- W3137239013 cites W2023949193 @default.
- W3137239013 cites W2026379469 @default.
- W3137239013 cites W2030056623 @default.
- W3137239013 cites W2038804998 @default.
- W3137239013 cites W2041269545 @default.
- W3137239013 cites W2046623913 @default.
- W3137239013 cites W2047679549 @default.
- W3137239013 cites W2055633783 @default.
- W3137239013 cites W2059284026 @default.
- W3137239013 cites W2059320976 @default.
- W3137239013 cites W2064572748 @default.
- W3137239013 cites W2066905497 @default.
- W3137239013 cites W2070016946 @default.
- W3137239013 cites W2072070625 @default.
- W3137239013 cites W2074175597 @default.
- W3137239013 cites W2089760642 @default.
- W3137239013 cites W2092292355 @default.
- W3137239013 cites W2092528758 @default.
- W3137239013 cites W2092824717 @default.
- W3137239013 cites W2094787322 @default.
- W3137239013 cites W2095025412 @default.
- W3137239013 cites W2101620445 @default.
- W3137239013 cites W2102778729 @default.
- W3137239013 cites W2110167662 @default.
- W3137239013 cites W2114565983 @default.
- W3137239013 cites W2115352199 @default.
- W3137239013 cites W2116715858 @default.
- W3137239013 cites W2117692326 @default.
- W3137239013 cites W2120054052 @default.
- W3137239013 cites W2121724388 @default.
- W3137239013 cites W2127776747 @default.
- W3137239013 cites W2128005193 @default.
- W3137239013 cites W2130000320 @default.
- W3137239013 cites W2131195370 @default.
- W3137239013 cites W2141282287 @default.
- W3137239013 cites W2147150851 @default.
- W3137239013 cites W2148432516 @default.
- W3137239013 cites W2164720489 @default.
- W3137239013 cites W2166346775 @default.
- W3137239013 cites W2260548596 @default.
- W3137239013 cites W2470906679 @default.
- W3137239013 cites W2509296969 @default.
- W3137239013 cites W2567502519 @default.
- W3137239013 cites W2608168866 @default.
- W3137239013 cites W2743640101 @default.
- W3137239013 cites W2755104158 @default.
- W3137239013 cites W2766566014 @default.
- W3137239013 cites W2804155993 @default.
- W3137239013 cites W2804842145 @default.
- W3137239013 cites W2810099487 @default.
- W3137239013 cites W2891348824 @default.
- W3137239013 cites W2903104520 @default.
- W3137239013 cites W2907436398 @default.
- W3137239013 cites W2919004555 @default.
- W3137239013 cites W2965790715 @default.
- W3137239013 cites W2971024483 @default.
- W3137239013 cites W2996313914 @default.
- W3137239013 cites W2997304996 @default.
- W3137239013 cites W3004814580 @default.
- W3137239013 cites W3020083757 @default.
- W3137239013 cites W3092703646 @default.
- W3137239013 cites W3096536399 @default.
- W3137239013 cites W3118190410 @default.
- W3137239013 cites W4229591526 @default.
- W3137239013 cites W4252851641 @default.