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• W3137263837 startingPage "1502" @default.
• W3137263837 abstract "Abstract In this counterpoint we critically appraise the evidence supporting therapeutic drug monitoring based on the vancomycin 24-hour area under the concentration-time curve (AUC24) for serious methicillin-resistant Staphylococcus aureus infections. We reveal methodologically weaknesses and inconsistencies in the data and suggest that, in the absence of clear and convincing evidence of benefit compared with modestly reducing trough targets, alternative strategies are more likely to result in superior safety and efficacy. These include focusing on fundamental antibiotic stewardship to limit vancomycin exposure overall, achieving earlier and more complete source control, and establishing alternative therapeutic options to vancomycin. Implementation of AUC24-based therapeutic drug monitoring will take resources away from these more promising, alternative solutions." @default.
• W3137263837 created "2021-03-29" @default.
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• W3137263837 date "2021-03-19" @default.
• W3137263837 modified "2023-10-16" @default.
• W3137263837 title "Should Therapeutic Drug Monitoring Based on the Vancomycin Area Under the Concentration-Time Curve Be Standard for Serious Methicillin-Resistant <i>Staphylococcus aureus</i> Infections?—No" @default.
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• W3137263837 doi "https://doi.org/10.1093/cid/ciaa1743" @default.
• W3137263837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33740050" @default.
• W3137263837 hasPublicationYear "2021" @default.
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