FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137291091> ?p ?o ?g. }

• W3137291091 endingPage "408" @default.
• W3137291091 startingPage "399" @default.
• W3137291091 abstract "BackgroundRecent breakthroughs in psychiatric genetics have implicated biological pathways onto which genetic risk for psychiatric disorders converges. However, these studies do not reveal the developmental time point(s) at which these pathways are relevant.MethodsWe aimed to determine the relationship between psychiatric risk and developmental gene expression relating to discrete biological pathways. We used postmortem RNA sequencing data (BrainSeq and BrainSpan) from brain tissue at multiple prenatal and postnatal time points, with summary statistics from recent genome-wide association studies of schizophrenia, bipolar disorder, and major depressive disorder. We prioritized gene sets for overall enrichment of association with each disorder and then tested the relationship between the association of their constituent genes with their relative expression at each developmental stage.ResultsWe observed relationships between the expression of genes involved in voltage-gated cation channel activity during early midfetal, adolescence, and early adulthood time points and association with schizophrenia and bipolar disorder, such that genes more strongly associated with these disorders had relatively low expression during early midfetal development and higher expression during adolescence and early adulthood. The relationship with schizophrenia was strongest for the subset of genes related to calcium channel activity, while for bipolar disorder, the relationship was distributed between calcium and potassium channel activity genes.ConclusionsOur results indicate periods during development when biological pathways related to the activity of calcium and potassium channels may be most vulnerable to the effects of genetic variants conferring risk for psychiatric disorders. Furthermore, they indicate key time points and potential targets for disorder-specific therapeutic interventions." @default.
• W3137291091 created "2021-03-29" @default.
• W3137291091 creator A5012211954 @default.
• W3137291091 creator A5013467589 @default.
• W3137291091 creator A5016459354 @default.
• W3137291091 creator A5018191302 @default.
• W3137291091 creator A5026352442 @default.
• W3137291091 creator A5028228908 @default.
• W3137291091 creator A5032995667 @default.
• W3137291091 creator A5042172394 @default.
• W3137291091 creator A5043264677 @default.
• W3137291091 creator A5054470203 @default.
• W3137291091 creator A5060932077 @default.
• W3137291091 creator A5075979341 @default.
• W3137291091 date "2021-09-01" @default.
• W3137291091 modified "2023-10-13" @default.
• W3137291091 title "Developmental Profile of Psychiatric Risk Associated With Voltage-Gated Cation Channel Activity" @default.
• W3137291091 cites W1127059495 @default.
• W3137291091 cites W1608316297 @default.
• W3137291091 cites W1837829179 @default.
• W3137291091 cites W1966940825 @default.
• W3137291091 cites W1972347916 @default.
• W3137291091 cites W1976694459 @default.
• W3137291091 cites W1977584840 @default.
• W3137291091 cites W1981722146 @default.
• W3137291091 cites W1983719168 @default.
• W3137291091 cites W1985301019 @default.
• W3137291091 cites W1990300831 @default.
• W3137291091 cites W1998741050 @default.
• W3137291091 cites W2009393491 @default.
• W3137291091 cites W2010348734 @default.
• W3137291091 cites W2023962370 @default.
• W3137291091 cites W2029926013 @default.
• W3137291091 cites W2030701454 @default.
• W3137291091 cites W2031405076 @default.
• W3137291091 cites W2045227722 @default.
• W3137291091 cites W2051158121 @default.
• W3137291091 cites W2051314902 @default.
• W3137291091 cites W2055655674 @default.
• W3137291091 cites W2055692942 @default.
• W3137291091 cites W2058166388 @default.
• W3137291091 cites W2075213530 @default.
• W3137291091 cites W2078059415 @default.
• W3137291091 cites W2087123651 @default.
• W3137291091 cites W2095878413 @default.
• W3137291091 cites W2097940171 @default.
• W3137291091 cites W2101357408 @default.
• W3137291091 cites W2102278945 @default.
• W3137291091 cites W2104549677 @default.
• W3137291091 cites W2107807525 @default.
• W3137291091 cites W2111489420 @default.
• W3137291091 cites W2117787632 @default.
• W3137291091 cites W2120731293 @default.
• W3137291091 cites W2126968375 @default.
• W3137291091 cites W2129031013 @default.
• W3137291091 cites W2131104106 @default.
• W3137291091 cites W2131271579 @default.
• W3137291091 cites W2132297623 @default.
• W3137291091 cites W2138207763 @default.
• W3137291091 cites W2138773108 @default.
• W3137291091 cites W2139852368 @default.
• W3137291091 cites W2142997789 @default.
• W3137291091 cites W2144315007 @default.
• W3137291091 cites W2146512944 @default.
• W3137291091 cites W2159248850 @default.
• W3137291091 cites W2163302580 @default.
• W3137291091 cites W2167623599 @default.
• W3137291091 cites W2209170701 @default.
• W3137291091 cites W2604808360 @default.
• W3137291091 cites W2734391724 @default.
• W3137291091 cites W2738082385 @default.
• W3137291091 cites W2745116209 @default.
• W3137291091 cites W2760464541 @default.
• W3137291091 cites W2763058017 @default.
• W3137291091 cites W2763350837 @default.
• W3137291091 cites W2765389138 @default.
• W3137291091 cites W2772624269 @default.
• W3137291091 cites W2777388159 @default.
• W3137291091 cites W2790033034 @default.
• W3137291091 cites W2799558871 @default.
• W3137291091 cites W2883175830 @default.
• W3137291091 cites W2888147011 @default.
• W3137291091 cites W2891652723 @default.
• W3137291091 cites W2895714694 @default.
• W3137291091 cites W2902500559 @default.
• W3137291091 cites W2904884010 @default.
• W3137291091 cites W2911487850 @default.
• W3137291091 cites W2912861074 @default.
• W3137291091 cites W2948949781 @default.
• W3137291091 cites W2950375827 @default.
• W3137291091 cites W2955503846 @default.
• W3137291091 cites W2963374797 @default.
• W3137291091 cites W2977618246 @default.
• W3137291091 cites W2989576931 @default.
• W3137291091 cites W2995971356 @default.
• W3137291091 cites W3005193150 @default.
• W3137291091 cites W3007694136 @default.
• W3137291091 cites W3080237557 @default.

• next