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• W3137310914 abstract "African-American women in the United States have an elevated risk of cervical cancer incidence and mortality. In the Mississippi Delta, cervical cancer disparities are particularly stark.We conducted a micro-costing study alongside a group randomized trial that evaluated the efficacy of a patient-centered approach (Choice between self-collection at home for HPV testing or current standard of care within the public health system in Mississippi) versus the current standard of care [Standard-of-care screening, involving cytology (i.e., Pap) and HPV co-testing at the Health Department clinics]. The interventions in both study arms were delivered by community health workers (CHW). Using cost, screening uptake, and colposcopy adherence data from the trial, we informed a mathematical model of HPV infection and cervical carcinogenesis to conduct a cost-effectiveness analysis comparing the Choice and Standard-of-care screening interventions among un/underscreened African-American women in the Mississippi Delta.When each intervention was simulated every 5 years from ages 25 to 65 years, the Standard-of-care screening strategy reduced cancer risk by 6.4% and was not an efficient strategy; Choice was more effective and efficient, reducing lifetime risk of cervical cancer by 14.8% and costing $62,720 per year of life saved (YLS). Screening uptake and colposcopy adherence were key drivers of intervention cost-effectiveness.Offering Choice to un/underscreened African-American women in the Mississippi Delta led to greater uptake than CHW-facilitated screening at the Health Department, and may be cost-effective.We evaluated the cost-effectiveness of an HPV self-collection intervention to reduce disparities." @default.
• W3137310914 created "2021-03-29" @default.
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• W3137310914 date "2021-03-26" @default.
• W3137310914 modified "2023-10-16" @default.
• W3137310914 title "Cost-Effectiveness of Offering Cervical Cancer Screening with HPV Self-Sampling among African-American Women in the Mississippi Delta" @default.
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• W3137310914 doi "https://doi.org/10.1158/1055-9965.epi-20-1673" @default.
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