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• W3137324518 endingPage "267" @default.
• W3137324518 startingPage "261" @default.
• W3137324518 abstract "Abstract A severe acute respiratory syndrome (SARS)-like coronavirus 2 (SARS-CoV-2) has recently caused a pandemic COVID-19 disease that infected approximately 94 million and killed more than 2,000,000 people worldwide. Like the SARS-CoV, SARS-CoV-2 also employs a receptor-binding motif (RBM) of its envelope spike protein for binding the host angiotensin-converting enzyme 2 (ACE2) to gain viral entry. Currently, extensive efforts are being made to produce vaccines against a surface fragment of a SARS-CoV-2, such as the spike protein, in order to boost protective antibodies that can inhibit virus-ACE2 interaction to prevent viral entry. It was previously unknown how spike protein-targeting antibodies would affect innate inflammatory responses to SARS-CoV-2 infections. Here we generated a highly purified recombinant protein corresponding to the RBM of SARS-CoV-2, and used it to screen for cross-reactive monoclonal antibodies (mAbs). We found two RBM-binding mAbs that competitively inhibited its interaction with human ACE2, and specifically blocked the RBM-induced GM-CSF secretion in both human peripheral blood mononuclear cells and murine macrophage cultures. Our findings have suggested a possible strategy to prevent SARS-CoV-2-elicited “cytokine storm,” and revealed a potentially anti-inflammatory and protective mechanism for SARS-CoV-2 spike-based vaccines." @default.
• W3137324518 created "2021-03-29" @default.
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• W3137324518 date "2021-03-24" @default.
• W3137324518 modified "2023-10-16" @default.
• W3137324518 title "Monoclonal antibodies capable of binding SARS-CoV-2 spike protein receptor-binding motif specifically prevent GM-CSF induction" @default.
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• W3137324518 doi "https://doi.org/10.1002/jlb.3covcra0920-628rr" @default.
• W3137324518 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8251270" @default.
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• W3137324518 hasPublicationYear "2021" @default.
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