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- W3137331314 abstract "With the growing challenges of bacteria becoming resistant to conventional antibiotics, antimicrobial peptides (AMPs) may offer a potential alternative. One of the most studied AMPs, the human cathelicidin derived AMP LL-37 is notable for its antimicrobial activity even though its mechanism of action is not fully understood yet. This work investigates the interaction of LL-37 with 1-Palmitoyl-2-oleoyl-sn-glycero-3-phospho-rac-(1-glycerol) (POPG) vesicles, which were employed as a bacterial membrane model given the common presence of this phospholipid in the bacterial membrane. Experimental techniques including small angle X-ray scattering, transmission electron microscopy and dynamic light scattering were used to characterize the interactions among LL-37 and POPG. Molecular dynamics simulations complement the experimental studies with molecular-level insights into the process. LL-37 was discovered to actively and critically interact with the POPG vesicles, modifying the membrane curvature that eventually leads to structural transformations from vesicles to mixed micelles. The results shed light on the mechanisms underlying the interactions among LL-37 and bacteria mimetic vesicles and can guide the further development of AMP based antimicrobial materials and therapies." @default.
- W3137331314 created "2021-03-29" @default.
- W3137331314 creator A5001901515 @default.
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- W3137331314 creator A5086065566 @default.
- W3137331314 date "2021-08-01" @default.
- W3137331314 modified "2023-10-10" @default.
- W3137331314 title "Antimicrobial peptide induced colloidal transformations in bacteria-mimetic vesicles: Combining in silico tools and experimental methods" @default.
- W3137331314 cites W103466436 @default.
- W3137331314 cites W1938354469 @default.
- W3137331314 cites W1964113525 @default.
- W3137331314 cites W1966078827 @default.
- W3137331314 cites W1967952287 @default.
- W3137331314 cites W1971042231 @default.
- W3137331314 cites W1978498560 @default.
- W3137331314 cites W1995395919 @default.
- W3137331314 cites W2001330064 @default.
- W3137331314 cites W2007767060 @default.
- W3137331314 cites W2009106357 @default.
- W3137331314 cites W2010883354 @default.
- W3137331314 cites W2011615074 @default.
- W3137331314 cites W2011714769 @default.
- W3137331314 cites W2014269957 @default.
- W3137331314 cites W2016923434 @default.
- W3137331314 cites W2020154280 @default.
- W3137331314 cites W2025230440 @default.
- W3137331314 cites W2028122134 @default.
- W3137331314 cites W2029667189 @default.
- W3137331314 cites W2036832969 @default.
- W3137331314 cites W2041436507 @default.
- W3137331314 cites W2044686884 @default.
- W3137331314 cites W2049774740 @default.
- W3137331314 cites W2049814814 @default.
- W3137331314 cites W2051864856 @default.
- W3137331314 cites W2057477511 @default.
- W3137331314 cites W2060164414 @default.
- W3137331314 cites W2063116767 @default.
- W3137331314 cites W2069520354 @default.
- W3137331314 cites W2076398541 @default.
- W3137331314 cites W2081693079 @default.
- W3137331314 cites W2082375525 @default.
- W3137331314 cites W2083212567 @default.
- W3137331314 cites W2094012988 @default.
- W3137331314 cites W2099103520 @default.
- W3137331314 cites W2105621770 @default.
- W3137331314 cites W2112476008 @default.
- W3137331314 cites W2114796839 @default.
- W3137331314 cites W2119267663 @default.
- W3137331314 cites W2127616123 @default.
- W3137331314 cites W2130018795 @default.
- W3137331314 cites W2132632272 @default.
- W3137331314 cites W2139966721 @default.
- W3137331314 cites W2144286887 @default.
- W3137331314 cites W2153099927 @default.
- W3137331314 cites W2159861471 @default.
- W3137331314 cites W2171268876 @default.
- W3137331314 cites W2175270296 @default.
- W3137331314 cites W2216819823 @default.
- W3137331314 cites W2229781928 @default.
- W3137331314 cites W2244307256 @default.
- W3137331314 cites W2312295720 @default.
- W3137331314 cites W2314292783 @default.
- W3137331314 cites W2326876131 @default.
- W3137331314 cites W2488529222 @default.
- W3137331314 cites W2494402508 @default.
- W3137331314 cites W2515273155 @default.
- W3137331314 cites W2515984871 @default.
- W3137331314 cites W2522514827 @default.
- W3137331314 cites W2571471998 @default.
- W3137331314 cites W2579968578 @default.
- W3137331314 cites W2738345393 @default.
- W3137331314 cites W2751821955 @default.
- W3137331314 cites W2767218508 @default.
- W3137331314 cites W2783066170 @default.
- W3137331314 cites W2800029597 @default.
- W3137331314 cites W2800406833 @default.
- W3137331314 cites W2800916409 @default.
- W3137331314 cites W2890686817 @default.
- W3137331314 cites W2897365795 @default.
- W3137331314 cites W2899121039 @default.
- W3137331314 cites W2907031483 @default.
- W3137331314 cites W2926564985 @default.
- W3137331314 cites W2942248766 @default.
- W3137331314 cites W2953928638 @default.
- W3137331314 cites W2958141845 @default.
- W3137331314 cites W2972309935 @default.
- W3137331314 cites W2976205999 @default.
- W3137331314 cites W3008957210 @default.
- W3137331314 cites W3048752454 @default.
- W3137331314 cites W3081910527 @default.
- W3137331314 cites W3167210072 @default.
- W3137331314 doi "https://doi.org/10.1016/j.jcis.2021.03.060" @default.
- W3137331314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33839361" @default.
- W3137331314 hasPublicationYear "2021" @default.