Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137337480> ?p ?o ?g. }
- W3137337480 endingPage "3811" @default.
- W3137337480 startingPage "3799" @default.
- W3137337480 abstract "Sclerosing cholangitis, characterized by biliary inflammation, fibrosis, and stricturing, remains one of the most challenging conditions of clinical hepatology. Geniposide (GE) has anti‐inflammatory, hepatoprotective, and cholagogic effects. Whether GE provides inhibition on the development of sclerosing cholangitis is unknown. Here, we investigated the role of GE in a mouse model in which mice were fed with 3,5‐diethoxycarbonyl‐1,4‐dihydrocollidine (DDC) for 4 weeks to induce sclerosing cholangitis. The results demonstrated that the increased hepatic gene expressions of pro‐inflammatory (IL‐6, VCAM‐1, MCP‐1, and F4/80) and profibrogenic markers (Col1α1, Col1α2, TGF‐β, and α‐SMA) in DDC feeding mice were reversed after treatment with GE. GE also suppressed expressions of CK19 and Ki67 in DDC‐fed mice, suggesting that GE could ameliorate DDC‐induced hepatocytes and cholangiocytes proliferation. In addition, GE significantly increased bile acids (BAs) secretion in bile, which correlated with induced expressions of hepatic FXR, BAs secretion transporters (BSEP, MRP2, MDR1, and MDR2), and reduced CYP7A1 mRNA expression. Furthermore, higher expressions of ileal FXR‐FGF15 signaling and reduced ASBT were also observed after GE treatment. Taken together, these data showed that GE could modulate inflammation, fibrosis, and BAs homeostasis in DDC‐fed mice, which lead to efficiently delay the progression of sclerosing cholangitis." @default.
- W3137337480 created "2021-03-29" @default.
- W3137337480 creator A5043544680 @default.
- W3137337480 creator A5044874902 @default.
- W3137337480 creator A5055725223 @default.
- W3137337480 creator A5071911403 @default.
- W3137337480 creator A5081675173 @default.
- W3137337480 creator A5083823176 @default.
- W3137337480 creator A5089489848 @default.
- W3137337480 date "2021-03-24" @default.
- W3137337480 modified "2023-10-18" @default.
- W3137337480 title "Geniposide suppresses liver injury in a mouse model of <scp>DDC</scp>‐induced sclerosing cholangitis" @default.
- W3137337480 cites W1553947658 @default.
- W3137337480 cites W1836306145 @default.
- W3137337480 cites W1850055005 @default.
- W3137337480 cites W1912346445 @default.
- W3137337480 cites W1918624535 @default.
- W3137337480 cites W1938807486 @default.
- W3137337480 cites W1966514588 @default.
- W3137337480 cites W1984988950 @default.
- W3137337480 cites W2012853846 @default.
- W3137337480 cites W2012962601 @default.
- W3137337480 cites W2014961412 @default.
- W3137337480 cites W2017961355 @default.
- W3137337480 cites W2034098793 @default.
- W3137337480 cites W2042630551 @default.
- W3137337480 cites W2057257420 @default.
- W3137337480 cites W2077296435 @default.
- W3137337480 cites W2091099965 @default.
- W3137337480 cites W2095266553 @default.
- W3137337480 cites W2098453507 @default.
- W3137337480 cites W2099603918 @default.
- W3137337480 cites W2099895479 @default.
- W3137337480 cites W2113638686 @default.
- W3137337480 cites W2116601505 @default.
- W3137337480 cites W2119468178 @default.
- W3137337480 cites W2124001862 @default.
- W3137337480 cites W2125168178 @default.
- W3137337480 cites W2131754309 @default.
- W3137337480 cites W2138139209 @default.
- W3137337480 cites W2138950515 @default.
- W3137337480 cites W2143030437 @default.
- W3137337480 cites W2143658065 @default.
- W3137337480 cites W2154807626 @default.
- W3137337480 cites W2163386417 @default.
- W3137337480 cites W2164787242 @default.
- W3137337480 cites W2301597241 @default.
- W3137337480 cites W2338451109 @default.
- W3137337480 cites W2510157910 @default.
- W3137337480 cites W2519544267 @default.
- W3137337480 cites W2563109049 @default.
- W3137337480 cites W2563888850 @default.
- W3137337480 cites W2591923276 @default.
- W3137337480 cites W2621333905 @default.
- W3137337480 cites W2761098930 @default.
- W3137337480 cites W2765322183 @default.
- W3137337480 cites W2777807075 @default.
- W3137337480 cites W2785876103 @default.
- W3137337480 cites W2797871134 @default.
- W3137337480 cites W2804318099 @default.
- W3137337480 cites W2806752052 @default.
- W3137337480 cites W2884708854 @default.
- W3137337480 cites W2892650582 @default.
- W3137337480 cites W2899739634 @default.
- W3137337480 cites W2939132737 @default.
- W3137337480 cites W4250007760 @default.
- W3137337480 doi "https://doi.org/10.1002/ptr.7086" @default.
- W3137337480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33763888" @default.
- W3137337480 hasPublicationYear "2021" @default.
- W3137337480 type Work @default.
- W3137337480 sameAs 3137337480 @default.
- W3137337480 citedByCount "14" @default.
- W3137337480 countsByYear W31373374802021 @default.
- W3137337480 countsByYear W31373374802022 @default.
- W3137337480 countsByYear W31373374802023 @default.
- W3137337480 crossrefType "journal-article" @default.
- W3137337480 hasAuthorship W3137337480A5043544680 @default.
- W3137337480 hasAuthorship W3137337480A5044874902 @default.
- W3137337480 hasAuthorship W3137337480A5055725223 @default.
- W3137337480 hasAuthorship W3137337480A5071911403 @default.
- W3137337480 hasAuthorship W3137337480A5081675173 @default.
- W3137337480 hasAuthorship W3137337480A5083823176 @default.
- W3137337480 hasAuthorship W3137337480A5089489848 @default.
- W3137337480 hasConcept C104317684 @default.
- W3137337480 hasConcept C126322002 @default.
- W3137337480 hasConcept C134018914 @default.
- W3137337480 hasConcept C149011108 @default.
- W3137337480 hasConcept C185592680 @default.
- W3137337480 hasConcept C2776914184 @default.
- W3137337480 hasConcept C2779134260 @default.
- W3137337480 hasConcept C2779399885 @default.
- W3137337480 hasConcept C2780559512 @default.
- W3137337480 hasConcept C2780615123 @default.
- W3137337480 hasConcept C2993667909 @default.
- W3137337480 hasConcept C36201501 @default.
- W3137337480 hasConcept C41260117 @default.
- W3137337480 hasConcept C44312359 @default.
- W3137337480 hasConcept C49039625 @default.