Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137344575> ?p ?o ?g. }
- W3137344575 endingPage "62" @default.
- W3137344575 startingPage "46" @default.
- W3137344575 abstract "Five years have passed since the World Health Organization released its Global Technical Strategy for Malaria (GTS). In that time, progress against malaria has plateaued. This review focuses on the implications of antimalarial drug resistance for the GTS and how interim progress in parasite genomics and antimalarial pharmacology offer a bulwark against it.For the first time, drug resistance-conferring genes have been identified and validated before their global expansion in malaria parasite populations. More efficient methods for their detection and elaboration have been developed, although low-density infections and polyclonality remain a nuisance to be solved. Clinical trials of alternative regimens for multidrug-resistant malaria have delivered promising results. New agents continue down the development pipeline, while a nascent infrastructure in sub-Saharan Africa for conducting phase I trials and trials of transmission-blocking agents has come to fruition after years of preparation.These and other developments can help inform the GTS as the world looks ahead to the next two decades of its implementation. To remain ahead of the threat that drug resistance poses, wider application of genomic-based surveillance and optimization of existing and forthcoming antimalarial drugs are essential." @default.
- W3137344575 created "2021-03-29" @default.
- W3137344575 creator A5013104153 @default.
- W3137344575 creator A5013612221 @default.
- W3137344575 creator A5017925493 @default.
- W3137344575 creator A5067895244 @default.
- W3137344575 creator A5077697410 @default.
- W3137344575 date "2021-03-14" @default.
- W3137344575 modified "2023-10-18" @default.
- W3137344575 title "Antimalarial Drug Resistance and Implications for the WHO Global Technical Strategy" @default.
- W3137344575 cites W1537278034 @default.
- W3137344575 cites W1594396564 @default.
- W3137344575 cites W1673362020 @default.
- W3137344575 cites W1729017034 @default.
- W3137344575 cites W1825014948 @default.
- W3137344575 cites W1906140483 @default.
- W3137344575 cites W1960873595 @default.
- W3137344575 cites W1964575165 @default.
- W3137344575 cites W1965185980 @default.
- W3137344575 cites W1969571661 @default.
- W3137344575 cites W1973235308 @default.
- W3137344575 cites W1984669077 @default.
- W3137344575 cites W1984979458 @default.
- W3137344575 cites W1987311633 @default.
- W3137344575 cites W1993347313 @default.
- W3137344575 cites W1995227882 @default.
- W3137344575 cites W1999748946 @default.
- W3137344575 cites W2000388030 @default.
- W3137344575 cites W2001500896 @default.
- W3137344575 cites W2009258477 @default.
- W3137344575 cites W2010067521 @default.
- W3137344575 cites W2013067281 @default.
- W3137344575 cites W2014392076 @default.
- W3137344575 cites W2019851585 @default.
- W3137344575 cites W2027678558 @default.
- W3137344575 cites W2035826427 @default.
- W3137344575 cites W2046415190 @default.
- W3137344575 cites W2048007395 @default.
- W3137344575 cites W2048317542 @default.
- W3137344575 cites W2049016946 @default.
- W3137344575 cites W2055730063 @default.
- W3137344575 cites W2074543807 @default.
- W3137344575 cites W2075937258 @default.
- W3137344575 cites W2080776262 @default.
- W3137344575 cites W2080956225 @default.
- W3137344575 cites W2081078606 @default.
- W3137344575 cites W2081496191 @default.
- W3137344575 cites W2084378609 @default.
- W3137344575 cites W2091422402 @default.
- W3137344575 cites W2091551182 @default.
- W3137344575 cites W2095182829 @default.
- W3137344575 cites W2096415021 @default.
- W3137344575 cites W2098738039 @default.
- W3137344575 cites W2100419926 @default.
- W3137344575 cites W2102988657 @default.
- W3137344575 cites W2104700616 @default.
- W3137344575 cites W2107930568 @default.
- W3137344575 cites W2110383454 @default.
- W3137344575 cites W2112170150 @default.
- W3137344575 cites W2114496951 @default.
- W3137344575 cites W2114625697 @default.
- W3137344575 cites W2117175172 @default.
- W3137344575 cites W2119156545 @default.
- W3137344575 cites W2120886990 @default.
- W3137344575 cites W2122539272 @default.
- W3137344575 cites W2123030025 @default.
- W3137344575 cites W2124634096 @default.
- W3137344575 cites W2124852796 @default.
- W3137344575 cites W2127174242 @default.
- W3137344575 cites W2128052069 @default.
- W3137344575 cites W2129428401 @default.
- W3137344575 cites W2130853973 @default.
- W3137344575 cites W2132323730 @default.
- W3137344575 cites W2132831164 @default.
- W3137344575 cites W2132923209 @default.
- W3137344575 cites W2133057125 @default.
- W3137344575 cites W2133977358 @default.
- W3137344575 cites W2135043406 @default.
- W3137344575 cites W2137130305 @default.
- W3137344575 cites W2137432389 @default.
- W3137344575 cites W2138700717 @default.
- W3137344575 cites W2138999699 @default.
- W3137344575 cites W2144926341 @default.
- W3137344575 cites W2149060705 @default.
- W3137344575 cites W2150389916 @default.
- W3137344575 cites W2155890819 @default.
- W3137344575 cites W2157824095 @default.
- W3137344575 cites W2159056342 @default.
- W3137344575 cites W2161311583 @default.
- W3137344575 cites W2161506676 @default.
- W3137344575 cites W2164334169 @default.
- W3137344575 cites W2165404715 @default.
- W3137344575 cites W2165540204 @default.
- W3137344575 cites W2166369726 @default.
- W3137344575 cites W2167625254 @default.
- W3137344575 cites W2168226801 @default.
- W3137344575 cites W2168267873 @default.
- W3137344575 cites W2168653390 @default.