Matches in SemOpenAlex for { <https://semopenalex.org/work/W3137347265> ?p ?o ?g. }
- W3137347265 abstract "Abstract Mucosal surfaces pose a challenging environment for efficient drug delivery. Various delivery strategies such as nanoparticles have been employed so far; yet, still yielding limited success. To address the need of efficient transmucosal drug delivery, this report presents the synthesis of novel disulfide‐containing dendritic polyglycerol (dPG)‐based nanogels and their preclinical testing. A bifunctional disulfide‐containing linker is coupled to dPG to act as a macromolecular crosslinker for poly‐ N ‐isopropylacrylamide (PNIPAM) and poly‐ N ‐isopropylmethacrylamide (PNIPMAM) in a precipitation polymerization process. A systematic analysis of the polymerization reveals the importance of a careful polymer choice to yield mucus‐degradable nanogels with diameters between 100 and 200 nm, low polydispersity, and intact disulfide linkers. Absorption studies in porcine intestinal tissue and human bronchial epithelial models demonstrate that disulfide‐containing nanogels are highly efficient in overcoming mucosal barriers. The nanogels efficiently degrade and deliver the anti‐inflammatory biomacromolecule etanercept into epithelial tissues yielding local anti‐inflammatory effects. Over the course of this work, several problems are encountered due to a limited availability of valid test systems for mucosal drug‐delivery systems. Hence, this study also emphasizes how critical a combined and multifaceted approach is for the preclinical testing of mucosal drug‐delivery systems, discusses potential pitfalls, and provides suggestions for solutions." @default.
- W3137347265 created "2021-03-29" @default.
- W3137347265 creator A5006770135 @default.
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- W3137347265 date "2021-03-14" @default.
- W3137347265 modified "2023-10-14" @default.
- W3137347265 title "Design and Testing of Efficient Mucus‐Penetrating Nanogels—Pitfalls of Preclinical Testing and Lessons Learned" @default.
- W3137347265 cites W160189274 @default.
- W3137347265 cites W1784652317 @default.
- W3137347265 cites W1961169379 @default.
- W3137347265 cites W1981515967 @default.
- W3137347265 cites W1985602590 @default.
- W3137347265 cites W1988706813 @default.
- W3137347265 cites W1988964423 @default.
- W3137347265 cites W1989506542 @default.
- W3137347265 cites W1994294415 @default.
- W3137347265 cites W1994701074 @default.
- W3137347265 cites W1996998707 @default.
- W3137347265 cites W2002626888 @default.
- W3137347265 cites W2006848221 @default.
- W3137347265 cites W2022132405 @default.
- W3137347265 cites W2022905205 @default.
- W3137347265 cites W2025868400 @default.
- W3137347265 cites W2028676020 @default.
- W3137347265 cites W2032454041 @default.
- W3137347265 cites W2036670913 @default.
- W3137347265 cites W2037261076 @default.
- W3137347265 cites W2039167760 @default.
- W3137347265 cites W2040071171 @default.
- W3137347265 cites W2041880062 @default.
- W3137347265 cites W2052756141 @default.
- W3137347265 cites W2059855607 @default.
- W3137347265 cites W2063805677 @default.
- W3137347265 cites W2064567039 @default.
- W3137347265 cites W2065644026 @default.
- W3137347265 cites W2066318078 @default.
- W3137347265 cites W2068744423 @default.
- W3137347265 cites W2068820688 @default.
- W3137347265 cites W2071286692 @default.
- W3137347265 cites W2072191117 @default.
- W3137347265 cites W2075872138 @default.
- W3137347265 cites W2082732215 @default.
- W3137347265 cites W2083492427 @default.
- W3137347265 cites W2086587366 @default.
- W3137347265 cites W2087376771 @default.
- W3137347265 cites W2105682688 @default.
- W3137347265 cites W2105887681 @default.
- W3137347265 cites W2108088303 @default.
- W3137347265 cites W2110954157 @default.
- W3137347265 cites W2114918609 @default.
- W3137347265 cites W2127038679 @default.
- W3137347265 cites W2127210744 @default.
- W3137347265 cites W2130166533 @default.
- W3137347265 cites W2140308222 @default.
- W3137347265 cites W2142613038 @default.
- W3137347265 cites W2148103005 @default.
- W3137347265 cites W2150918607 @default.
- W3137347265 cites W2151080741 @default.
- W3137347265 cites W2154555351 @default.
- W3137347265 cites W2157757382 @default.
- W3137347265 cites W2159206613 @default.
- W3137347265 cites W2162869410 @default.
- W3137347265 cites W2175375867 @default.
- W3137347265 cites W2177968623 @default.
- W3137347265 cites W2192049920 @default.
- W3137347265 cites W2192104109 @default.
- W3137347265 cites W2194473901 @default.
- W3137347265 cites W2219964339 @default.
- W3137347265 cites W2259975048 @default.
- W3137347265 cites W2301722455 @default.
- W3137347265 cites W2404255229 @default.
- W3137347265 cites W2413962185 @default.
- W3137347265 cites W2417678778 @default.
- W3137347265 cites W2491811434 @default.
- W3137347265 cites W2509715372 @default.
- W3137347265 cites W2515968685 @default.
- W3137347265 cites W2518855932 @default.
- W3137347265 cites W2522111877 @default.
- W3137347265 cites W2535932582 @default.
- W3137347265 cites W2556369366 @default.
- W3137347265 cites W2560198191 @default.
- W3137347265 cites W2570380080 @default.
- W3137347265 cites W2765425655 @default.
- W3137347265 cites W2769249209 @default.
- W3137347265 cites W2775453415 @default.
- W3137347265 cites W2802865674 @default.
- W3137347265 cites W2887951414 @default.
- W3137347265 cites W2917421705 @default.
- W3137347265 cites W2948521495 @default.
- W3137347265 cites W2952855377 @default.
- W3137347265 cites W4245957869 @default.
- W3137347265 cites W4293247451 @default.